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View Structure Prediction Details

Protein: MIG2
Organism: Saccharomyces cerevisiae
Length: 382 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MIG2.

Description E-value Query
Range		 Subject
Range
ZNF287 - zinc finger protein 287
 0.0 [2..380] [374..751]
ZSCA2_MOUSE - Zinc finger and SCAN domain-containing protein 2 OS=Mus musculus GN=Zscan2 PE=1 SV=1
 0.0 [2..380] [235..612]
ZN252_CANLF - Zinc finger protein 252 OS=Canis lupus familiaris GN=ZNF252 PE=2 SV=1
 0.0 [2..380] [413..790]

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Predicted Domain #1
Region A:
Residues: [1-66] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPKKQTNFPV DNENRPFRCD TCHRGFHRLE HKKRHLRTHT GEKPHHCAFP GCGKSFSRSD  60
   61 ELKRHM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 103.927757
Match: 2gliA_
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
structure-specific DNA binding 0.790771220986801 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
double-stranded DNA binding 0.53991278722671 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [67-117] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RTHTGQSQRR LKKASVQKQE FLTVSGIPTI ASGVMIHQPI PQVLPANMAI N

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 103.927757
Match: 2gliA_
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [118-202] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VQAVNGGNII HAPNAVHPMV IPIMAQPAPI HASAASFQPA TSPMPISTYT PVPSQSFTSF  60
   61 QSSIGSIQSN SDVSSIFSNM NVRVN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
structure-specific DNA binding 0.790771220986801 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
double-stranded DNA binding 0.53991278722671 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [203-255] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPRSVPNSPN DGYLHQQHIP QQYQHQTASP SVAKQQKTFA HSLASALSTL QKR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 128.68867
Match: 1lu6A_
Description: No description for 1lu6A_ was found.

Predicted Domain #5
Region A:
Residues: [256-382] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPVSAPSTTI ESPSSPSDSS HTSASSSAIS LPFSNAPSQL AVAKELESVY LDSNRYTTKT  60
   61 RRERAKFEIP EEQEEDTNNS SSGSNEEEHE SLDHESSKSR KKLSGVKLPP VRNLLKQIDV 120
  121 FNGPKRV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 128.68867
Match: 1lu6A_
Description: No description for 1lu6A_ was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle