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Protein Overview: THI22

General Information:
Name(s) found: THI22 / YPR121W [SGD]
Description(s) found:
Found 20 descriptions.
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  • Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 572 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: thiamin biosynthetic process [IEPLink to PubMed article][IGILink to PubMed article]
    Molecular Function: phosphomethylpyrimidine kinase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVIILLGLCT LGFPRTAFCP SIMTNSTVSI NTPPPYLTLA CNEKLPTVMS IAGSDSSGGA  60
   61 GVEADIKTIT AHRCYAMTCV TTLTAQTPVK VYGAHNIPKK MVSQILDANL QDMKCNVIKT 120
  121 GMLTVDAIEV LHEKLLQLGE NRPKLVIDPV LCAASDSSPT GKDVVSLIIE KISPFADILT 180
  181 PNISDCFMLL GENREVSKLQ DVLEIAKDLS RITNCSNILV KGGHIPCDDG KEKHITDVLY 240
  241 LGAEQKFITF KGQFVNTTRT HGAGCTLASA IASNLARGYS LSQSVYGGIE YVQNAIAIGC 300
  301 DVTKKAVKVG PINHVYAVEI PLEKMLTDEC FTASDAVPKK PIEGSLDKIP GGSFFNYLIN 360
  361 HPKVKPHWDA YVNHEFVKRV ADGTLERKKF QFFIEQDYLY LIDYVRVCCV TGSKSPTLED 420
  421 LEKDLVIADC ARNELNEHER RLREEFGVKD PDYLQKIKRG PALRAYCRYL IDISRRGNWQ 480
  481 EIVVALNPCL MGYVYAVDKV KDKITAAEGS IYSEWCDTCA SSFCYQAVLE GERLMNHILE 540
  541 TYPPDQLDSL VTIFARGCEL ETNFWTAAME YE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) AAC3 ACO1 ADK1 ATP3 BCY1 BUD9 CAR2 CCL1 CDC15 CLU1 COP1 CPA2 CYS4 DAK2 DBP8 GND1 GPH1 GTO1 HEF3 HOR2 HXT6 KGD1 LAA1 LSC1 LYS1 MET18 NAN1 OMS1 OYE2 PFK1 PGM2 PRP11 RAD3 REX2 RHR2 RNR1 RNR2 RPN1 RPT3 SAH1 SEC26 SEC27 SHM2 SNO2 SSK2 SSN8 TFP1 THI22 THO2 TIF1, TIF2 TIF4631 TPK2 TPK3 UBP15 UTP13 VMA6 VPS21 YBL104C YBR028C YCK1 YCK2 YCK3 YDL086W YGR111W YGR250C YPT53

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen YLR224W THI22 1 Unpublished Fields Lab Data
    View Screen UBC7 THI22 1 Unpublished Fields Lab Data
    View Screen SPT21 THI22 1 Unpublished Fields Lab Data
    View Screen NAF1 THI22 1 Hazbun TR, et al. (2003)

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..320] PSI-BLAST 308.9794 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase (HMP-phosphate kinase, ThiD)
    2 View Details [321..572] MSA 67.505996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphomethylpyrimidine kinase activity
    		•  3.972577109569 bayes_pls_golite062009
  • kinase activity
    		•  2.74755351135221 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.43969902311075 bayes_pls_golite062009
  • carbohydrate kinase activity
    		•  2.34445983129813 bayes_pls_golite062009
  • thiaminase activity
    		•  2.33383885490808 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.31951903725366 bayes_pls_golite062009
  • phosphotransferase activity, phosphate group as acceptor
    		•  2.29466565429735 bayes_pls_golite062009
  • transferase activity
    		•  2.15883296431019 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.14277879659132 bayes_pls_golite062009
  • DNA binding
    		•  1.96007866678724 bayes_pls_golite062009
  • catalytic activity
    		•  1.74474587246986 bayes_pls_golite062009
  • binding
    		•  1.4216897826135 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.37866801006693 bayes_pls_golite062009
  • hydroxyethylthiazole kinase activity
    		•  1.28568044601242 bayes_pls_golite062009
  • thiamin-phosphate diphosphorylase activity
    		•  1.27602595951972 bayes_pls_golite062009
  • transcription factor activity
    		•  1.22047633822494 bayes_pls_golite062009
  • phosphofructokinase activity
    		•  0.37205329607884 bayes_pls_golite062009
  • pyridoxal kinase activity
    		•  0.217863391052366 bayes_pls_golite062009
  • protein binding
    		•  0.117280046908929 bayes_pls_golite062009
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  2.47421036599568 bayes_pls_golite062009
  • binding
    		•  1.80342520508546 bayes_pls_golite062009
  • transcription activator activity
    		•  0.765671114434415 bayes_pls_golite062009
  • catalytic activity
    		•  0.476060647762462 bayes_pls_golite062009
  • protein binding
    		•  0.438212622992804 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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