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Protein Overview: SCD5

General Information:
Name(s) found: SCD5 / YOR329C [SGD]
Description(s) found:
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  • gi|6324905|ref|NP_014974.1| Protein required for normal cortical actin organization and endocytosis; multicopy suppressor of clathrin deficiency; acts as a targeting subunit for protein phosphatase type 1; Scd5p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|464739|sp|P34758.1|SCD5_YEAST RecName: Full=Protein SCD5; AltName: Full=Protein FTB1 [NCBI NR]
  • gi|424128|gb|AAB09719.1| Scd5p [NCBI NR]
  • pir||S62061 SCD5 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1420719|emb|CAA99650.1| SCD5 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1163065|emb|CAA89976.1| SCD5 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1147768|gb|AAA85443.1| Ftb1p [NCBI NR]
  • Protein SCD5 OS=Saccharomyces cerevisiae GN=SCD5 PE=1 SV=1 [Swiss-Prot]
  • SCD5 Suppressor of clathrin deficiency [mips]
  • Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency [SGD]
  • (P34758) SCD5 protein (FTB1 protein) [4932.FASTACCERV.txt]
  • Chr XV from 939342-936724, reverse complement [hmr_yeast5_DM3-1_pombe.fasta]
  • Chr XV from 936723-939341, reverse complement [yeastorf3.fasta]
  • Chr XV from 936724-939342, reverse complement [yeastorf4.fasta]
  • SCD5, Chr XV from 936723-939341, reverse complement [yeast_orfs2]
  • SCD5 SGDID:S0005856, Chr XV from 939344-936726, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Multicopy suppressor of clathrin deficiency and of ts ipl1 mutants [Saccharomyces cerevisiae]gi|1163065|emb|CAA89976.1| SCD5 [Saccharomyces cerevisiae]gi|1420719|emb|CAA99650.1| SCD5 [Saccharomyces cerevisiae]gi|2133119|pir||S62061 SCD5 protein - yeast [nrdb_11152004_Chlamydomonas]
  • SCD5 SGDID:S000005856, Chr XV from 939344-936726, reverse complement, Verified ORF, "Protein required for normal cortical actin organization and endocytosis; multicopy suppressor of clathrin deficiency; acts as a targeting subunit for protein phosphatase [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • SCD5 SGDID:S000005856, Chr XV from 939346-936728, reverse complement, Verified ORF, "Protein required for normal cortical actin organization and endocytosis; multicopy suppressor of clathrin deficiency; acts as a targeting subunit for protein phosphatase [yeast-contam.fasta]
  • SCD5 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Protein required for normal cortical actin organization and endocytosis; multicopy suppressor of clathrin deficiency; acts as a targeting subunit for protein phosphatase type 1; Scd5p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Protein SCD5 (Protein FTB1) [nr-271106-contam.fasta]
  • Scd5p [nr-271106-contam.fasta]
  • Ftb1p [nr-271106-contam.fasta]
  • SCD5 SGDID:S000005856, Chr XV from 939346-936728, reverse complement, Verified ORF, "Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta]
  • SCD5 SGDID:S000005856, Chr XV from 939346-936728, reverse complement, Verified ORF, "Protein required for normal cortical actin organization and endocytosis; multicopy suppressor of clathrin deficiency; acts as a targeting subunit for protein phosphatase type 1" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • SCD5 SGDID:S000005856, Chr XV from 939346-936728, reverse complement, Verified ORF, "Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency" [SGDyeast.20101221.fasta]
  • Protein SCD5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SCD5 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • SCD5 SGDID:S000005856, Chr XV from 939349-936731, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency" [yeast-030211-contam.fasta]
  • SCD5 SGDID:S000005856, Chr XV from 939349-936731, Genome Release 64-2-1, reverse complement, Verified ORF, "Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency" [20141208_orf_trans.fasta]
  • YOR329C SGDID:S000005856, Chr XV from 939349-936731, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 872 amino acids

    Gene Ontology:
    Cellular Component: peripheral to membrane of membrane fraction [IDALink to PubMed article]
    actin cortical patch [IDALink to PubMed article]
    Biological Process: cortical actin cytoskeleton organization [IMPLink to PubMed article]
    actin filament organization [TASLink to PubMed article]
    endocytosis [TASLink to PubMed article]
    protein secretion [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: protein binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFDWLNVPG LDLSSGDQAE KRPSNGLGPP SVSFDFGINT AAPHDSSFWD QGSRSHSDTT  60
   61 LSYRNNHSNT AADNATNVSS PQKDNPPNGE VRTLSGGDVY AESPEDMQVP LSLSQNQLTH 120
  121 EEIRTYLRWY HYICLRTHGK LVRLNDVFRF LTNFNLSQKV KDRIVEIFRS CKNALNIGQF 180
  181 FAVLRLVSRA IIYGILPLRR MILEKAPVPK PRPILSSENH EEVYEEVEDD DSSAKTGDQK 240
  241 VDFDSFASLL LTGKTTRKRV RRRIKNLNFK SKKVRFSEHI TFQDPPNLNQ ESSNNSEARK 300
  301 QDPDAEDEDQ DSNNDSPLDF TLPMDQLLKR LYKRRKNSGL VSSLPSEQQE TEEEKKVLED 360
  361 MKDSLSHFKQ IQTVDSASLP ISSVFLQNGN TLPTSNVNNT TVPQQLPLEP LKPTATGSAN 420
  421 HLVREEYNQG LHPSNGAIQT GLQPLKPTAT GSANYLMRSH MEQPQSIKPS STPETVTNSG 480
  481 GLQPLKPTAT GSANYLMKQH ISPSVNNPVS SMFQAQFTNQ SSSPQSTGPA FLNSPNITLP 540
  541 QSNQQQPYQE VNPTQAKIEP SNISPQHTYS NNVRINNGNI VSMPKVEITG AFPPQNTLPQ 600
  601 HQQSHLLSPQ NTIPQHQRSQ LISPQNTFTQ NQPILSPQHT YSNNQATMIS PQNTYTNNQQ 660
  661 QPQHLPPPPP PRAQQQQQGA IVPPQHMYSN VQKQNNLVPT QPSYTNSPSI QSPNFLSPQN 720
  721 AANSYFQSLL SSSPSPNPTP SNASTVNGNN ASNGISSFQN TSAAMNNTQS HQTYIQQQQQ 780
  781 QQTQQRIYGG QLSQMQQHPG QLHLNNSDIH SQPNKPNYGM LGQQVHQQQQ QQQQQFPFTA 840
  841 DVNRSNSSDI LGNLQSLQQQ VDALQIQYNR RP

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) CFT1 CIC1 CLU1 ERB1 FIN1 FIP1 FPR3 FPR4 GLC7 GLC8 GPH1 HER1 KEL1 MHP1 NSA1 REG1 RRP17 SCD5 SDS22 SEN1 SPB1 SUI2 SUI3 YTM1
    View Details Qiu et al. (2008) ABP1 ACT1 AIP1 ATG20 COF1 CRN1 EDE1 END3 LAS17 LST8 PAN1 SCD5 SLA1 SLA2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen GLC7 SCD5 2 Uetz P, et al. (2000)
    View Screen FRT2 SCD5 1 Unpublished Fields Lab Data
    View Screen KAP104 SCD5 1 Unpublished Fields Lab Data
    View Screen KAP104 SCD5 1 Unpublished Fields Lab Data
    View Screen ECM29 SCD5 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SCD5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..205] deduced N/A No confident structure predictions are available.
    2 View Details [206..535] MSA 4.304997 View MSA. No confident structure predictions are available.
    3 View Details [536..712] PSI-BLAST 2.045757 Sec24
    4 View Details [713..872] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle