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Protein Overview: ELG1

General Information:
Name(s) found: ELG1 / YOR144C [SGD]
Description(s) found:
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  • gi|6324718|ref|NP_014787.1| Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; involved in homologous recombination-mediated DNA repair; [NCBI NR]
  • gi|59799383|sp|Q12050.1|ELG1_YEAST RecName: Full=Telomere length regulation protein ELG1; AltName: Full=Telomere elongation suppressor ELG1; AltName: Full=Regulator of Ty1 transposition protein 110 [NCBI NR]
  • pir||S61698 hypothetical protein YOR144c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1420366|emb|CAA99348.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1164987|emb|CAA64062.1| YOR3510c [Saccharomyces cerevisiae] [NCBI NR]
  • Telomere length regulation protein ELG1 OS=Saccharomyces cerevisiae GN=ELG1 PE=1 SV=1 [Swiss-Prot]
  • ELG1 Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity [mips]
  • Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; involved in homologous recombination-mediated DNA repair [SGD]
  • >Q12050 (Q12050) YOR3510C from chromosome XV (O3510P) [4932.FASTACCERV.txt]
  • Chr XV from 605092-602717, reverse complement [hmr_yeast5_DM3-1_pombe.fasta]
  • Chr XV from 602716-605091, reverse complement [yeastorf3.fasta]
  • Chr XV from 602717-605092, reverse complement [yeastorf4.fasta]
  • EFD1, Chr XV from 602716-605091, reverse complement [yeast_orfs2]
  • ELG1 SGDID:S0005670, Chr XV from 605092-602717, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Elg1p [Saccharomyces cerevisiae]gi|1420366|emb|CAA99348.1| unnamed protein product [Saccharomyces cerevisiae]gi|1164987|emb|CAA64062.1| YOR3510c [Saccharomyces cerevisiae]gi|2132067|pir||S61698 hypothetical protein YOR144c - yeast (Saccharomyces cerevi [nrdb_11152004_Chlamydomonas]
  • (Q12050) YOR3510c protein (S.cerevisiae chromosome XV reading frame ORF YOR144c) [cerv4932.FASTAC]
  • ELG1 SGDID:S000005670, Chr XV from 605092-602717, reverse complement, Verified ORF, "Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; m [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • ELG1 SGDID:S000005670, Chr XV from 605093-602718, reverse complement, Verified ORF, "Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; m [yeast-contam.fasta]
  • ELG1 SGDID:S000005670, Chr XV from 605093-602718, reverse complement, Verified ORF, "Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; i [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • YOR3510c [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Telomere length regulation protein ELG1 (Telomere elongation suppressor ELG1) [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; mutants are sensitive to DNA damage; Elg1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • ELG1 SGDID:S000005670, Chr XV from 605093-602718, reverse complement, Verified ORF, "Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; involved in homologous recombination-mediated DNA repair" [yeast-bovrabprots.fasta]
  • ELG1 SGDID:S000005670, Chr XV from 605093-602718, reverse complement, Verified ORF, "Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; mutants are sensitive to DNA damage" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • Telomere length regulation protein ELG1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ELG1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • ELG1 SGDID:S000005670, Chr XV from 605092-602717, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis" [yeast-030211-contam.fasta]
  • ELG1 SGDID:S000005670, Chr XV from 605092-602717, Genome Release 64-2-1, reverse complement, Verified ORF, "Subunit of an alternative replication factor C complex; important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication" [20141208_orf_trans.fasta]
  • YOR144C SGDID:S000005670, Chr XV from 605092-602717, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 791 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    DNA replication factor C complex [TASLink to PubMed article]
    Biological Process: DNA replication [TASLink to PubMed article]
    double-strand break repair via homologous recombination [IMPLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article][TASLink to PubMed article]
    negative regulation of transposition, DNA-mediated [IMPLink to PubMed article]
    negative regulation of DNA recombination [NASLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRHVSLSDI LTGNKRKVRR QDALQITIDD ENDTESGTFD ARTAKHDDSS VIFLNHSVVK  60
   61 PIEAVSTNHK SAKEFLMTKR TKEKCDDDDD DLIVISDKSP KSETNCSKIA LSQEHEDDIS 120
  121 IISTSRIKSS LLNERASKIK NFLKHETTDT FKRLNSISKL NEIEPPLPLH QSIFPVGDKE 180
  181 LSDRSVDIPL PFRTIPPLNH NFLPSDYESL KDKNSASCIP VRYQAPVLLG TNIKRNTTLT 240
  241 WPQLFKPVTL KQVLIEPKLK LRIKNWIETS FHTLEKPTLR NRLLNRINPN KQQGSGDELA 300
  301 NFIVPDLEED ENLRPDFYRN GEANSSLSEF VPLMILHGNS IGKKTLIQTI MREIAGDDNS 360
  361 YQIYEVNSNM NRSKKDLLDI LLDFTTTHYV KDSSKRKSDY GLVLFNDVDV LFKEHDRGYW 420
  421 AMISKLCEFS RRPLVLTCKD LSLVPSELIA LASEQNSLFH TKKISTSTVY AFLTKYLKSL 480
  481 EIEVCDDWLR DVVKQNNADI RKCLMHLQFW CVDTEADLIS SKNRLPVLTS TLGSSVKDIS 540
  541 QLTDLLSIND VIGQATLNRS MVRQEIDSTT MTPEKVNTFQ DQNLDDEMKL KFDYVIDYKL 600
  601 HLNDPNRQPL LPFELNIYQH IQEQLEARYS YVREANHRLD NEYLVNRFKK MTESTLNFLA 660
  661 SRIPKYDHLQ SARRTRNSKK ISDILNQFKG IYNDETLNEN AEIDLLSATT QQIKAEINPF 720
  721 VFEIAKSDAN VKNENKQIFE LHSENVSERR YKDLVYQLSQ EGVLKNVWFN ADPSIVVRKW 780
  781 EHLHSGFSKN K

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ELG1 RFC2 RFC3 RFC4 RFC5
    View Details Krogan NJ, et al. (2006) ELG1 RFC1 RFC2 RFC3 RFC4 RFC5
    View Details Gavin AC, et al. (2006) ELG1 RFC1 RFC3 RFC4 RFC5
    View Details Gavin AC, et al. (2002) CTF18 CTF8 DPB2 ELG1 OLA1 POL2 RFC1 RFC2 RFC3 RFC4 RFC5 TOP2 VPS13 YMR181C
    View Details Ho Y, et al. (2002) ACO1 ELG1 GUS1 RFC1 RFC2 RFC4 RNQ1 SAN1
    View Details Qiu et al. (2008) DPB11 ELG1 MRC1 POL31

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ELG1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..162] PSI-BLAST 30.0 ClpB
    2 View Details [163..238] deduced N/A No confident structure predictions are available.
    3 View Details [239..302]
    [465..530]    		 PSI-BLAST 68.0 Replication factor C
    4 View Details [303..464]
    [531..692]    		 PSI-BLAST 68.0 Replication factor C
    5 View Details [693..791] deduced N/A Confident ab initio structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA clamp loader activity
    		•  6.27436520855727 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  6.24135351729061 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.72462789867829 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • DNA helicase activity
    		•  2.2817164193758 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.21184938313192 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.13284212711072 bayes_pls_golite062009
  • telomeric DNA binding
    		•  1.98044285764127 bayes_pls_golite062009
  • DNA binding
    		•  1.94055378599526 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.88455339138556 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.83584389083042 bayes_pls_golite062009
  • microtubule motor activity
    		•  1.6537049553461 bayes_pls_golite062009
  • helicase activity
    		•  1.16085745407703 bayes_pls_golite062009
  • motor activity
    		•  1.14667913749579 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  0.971476020912368 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.928091843881235 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.720649395550746 bayes_pls_golite062009
  • transcription factor activity
    		•  0.697256579145077 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.677612020025357 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.59513742813869 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.59513742813869 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.58862275163252 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.500462538667228 bayes_pls_golite062009
  • single-stranded telomeric DNA binding
    		•  0.295227908763532 bayes_pls_golite062009
  • four-way junction helicase activity
    		•  0.26252931460003 bayes_pls_golite062009
  • double-stranded telomeric DNA binding
    		•  0.19515047906201 bayes_pls_golite062009
  • exodeoxyribonuclease V activity
    		•  0.185603938981231 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.147579541298736 bayes_pls_golite062009
  • nucleotide binding
    		•  0.114848452385726 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.113504049290503 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.111293884322157 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.10713474095071 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0916519414118148 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0915913646217636 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.089234257580272 bayes_pls_golite062009
  • actin binding
    		•  0.00482938540552702 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle