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View Structure Prediction Details

Protein: ELG1
Organism: Saccharomyces cerevisiae
Length: 791 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ELG1.

Description E-value Query
Range
Subject
Range
ELG1_YEAST - Telomere length regulation protein ELG1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...
ELG1 - Protein required for S phase progression and telomere homeostasis, forms an alternative replication ...
0.0 [1..791] [1..791]
CLPAA_SOLLC - ATP-dependent Clp protease ATP-binding subunit ClpA homolog CD4A, chloroplastic OS=Solanum lycopersi...
0.0 [47..578] [321..902]
gi|17132093, gi|... - gi|17230491|ref|NP_487039.1| endopeptidase Clp ATP-binding chain [Nostoc sp. PCC 7120], gi|17132093|...
gi|25289939 - pir||AH2180 endopeptidase Clp ATP-binding chain [imported] - Nostoc sp. (strain PCC 7120)
0.0 [47..479] [242..749]
gi|11265212, gi|... - gi|7576225|emb|CAB87915.1| AtClpC [Arabidopsis thaliana], gi|18408722|ref|NP_566912.1| ATCLPC (CASEI...
0.0 [49..577] [344..921]
CLPC_PEA - Chaperone protein ClpC, chloroplastic OS=Pisum sativum PE=2 SV=1
4.0E-99 [47..609] [319..917]
gi|7428212 - pir||S76330 endopeptidase Clp (EC 3.4.21.-) ATP-binding chain C [similarity] - Synechocystis sp. (st...
gi|16331384, gi|... - gi|16331384|ref|NP_442112.1| ATP-dependent Clp protease regulatory subunit [Synechocystis sp. PCC 68...
1.0E-98 [47..494] [227..756]

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Predicted Domain #1
Region A:
Residues: [1-162]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRHVSLSDI LTGNKRKVRR QDALQITIDD ENDTESGTFD ARTAKHDDSS VIFLNHSVVK  60
   61 PIEAVSTNHK SAKEFLMTKR TKEKCDDDDD DLIVISDKSP KSETNCSKIA LSQEHEDDIS 120
  121 IISTSRIKSS LLNERASKIK NFLKHETTDT FKRLNSISKL NE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.0
Match: 1jbkA_
Description: ClpB
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA clamp loader activity 6.27436520855727 bayes_pls_golite062009
protein-DNA loading ATPase activity 6.24135351729061 bayes_pls_golite062009
DNA-dependent ATPase activity 2.72462789867829 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
DNA helicase activity 2.2817164193758 bayes_pls_golite062009
nucleic acid binding 2.21184938313192 bayes_pls_golite062009
pyrophosphatase activity 2.13284212711072 bayes_pls_golite062009
telomeric DNA binding 1.98044285764127 bayes_pls_golite062009
DNA binding 1.94055378599526 bayes_pls_golite062009
ATP-dependent DNA helicase activity 1.88455339138556 bayes_pls_golite062009
transcription regulator activity 1.83584389083042 bayes_pls_golite062009
microtubule motor activity 1.6537049553461 bayes_pls_golite062009
helicase activity 1.16085745407703 bayes_pls_golite062009
motor activity 1.14667913749579 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.971476020912368 bayes_pls_golite062009
DNA polymerase activity 0.928091843881235 bayes_pls_golite062009
structure-specific DNA binding 0.720649395550746 bayes_pls_golite062009
transcription factor activity 0.697256579145077 bayes_pls_golite062009
transcription repressor activity 0.677612020025357 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.59513742813869 bayes_pls_golite062009
ATP-dependent helicase activity 0.59513742813869 bayes_pls_golite062009
double-stranded DNA binding 0.58862275163252 bayes_pls_golite062009
cytoskeletal protein binding 0.500462538667228 bayes_pls_golite062009
single-stranded telomeric DNA binding 0.295227908763532 bayes_pls_golite062009
four-way junction helicase activity 0.26252931460003 bayes_pls_golite062009
double-stranded telomeric DNA binding 0.19515047906201 bayes_pls_golite062009
exodeoxyribonuclease V activity 0.185603938981231 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.147579541298736 bayes_pls_golite062009
nucleotide binding 0.114848452385726 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.113504049290503 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.111293884322157 bayes_pls_golite062009
purine nucleotide binding 0.10713474095071 bayes_pls_golite062009
purine ribonucleotide binding 0.0916519414118148 bayes_pls_golite062009
ribonucleotide binding 0.0915913646217636 bayes_pls_golite062009
structural constituent of ribosome 0.089234257580272 bayes_pls_golite062009
actin binding 0.00482938540552702 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [163-238]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IEPPLPLHQS IFPVGDKELS DRSVDIPLPF RTIPPLNHNF LPSDYESLKD KNSASCIPVR  60
   61 YQAPVLLGTN IKRNTT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [239-302]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTWPQLFKPV TLKQVLIEPK LKLRIKNWIE TSFHTLEKPT LRNRLLNRIN PNKQQGSGDE  60
   61 LANF

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [465-530]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STSTVYAFLT KYLKSLEIEV CDDWLRDVVK QNNADIRKCL MHLQFWCVDT EADLISSKNR  60
   61 LPVLTS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 68.0
Match: 1iqpA_
Description: Replication factor C
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [303-464]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IVPDLEEDEN LRPDFYRNGE ANSSLSEFVP LMILHGNSIG KKTLIQTIMR EIAGDDNSYQ  60
   61 IYEVNSNMNR SKKDLLDILL DFTTTHYVKD SSKRKSDYGL VLFNDVDVLF KEHDRGYWAM 120
  121 ISKLCEFSRR PLVLTCKDLS LVPSELIALA SEQNSLFHTK KI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [531-692]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLGSSVKDIS QLTDLLSIND VIGQATLNRS MVRQEIDSTT MTPEKVNTFQ DQNLDDEMKL  60
   61 KFDYVIDYKL HLNDPNRQPL LPFELNIYQH IQEQLEARYS YVREANHRLD NEYLVNRFKK 120
  121 MTESTLNFLA SRIPKYDHLQ SARRTRNSKK ISDILNQFKG IY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 68.0
Match: 1iqpA_
Description: Replication factor C
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [693-791]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDETLNENAE IDLLSATTQQ IKAEINPFVF EIAKSDANVK NENKQIFELH SENVSERRYK  60
   61 DLVYQLSQEG VLKNVWFNAD PSIVVRKWEH LHSGFSKNK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.840 0.045 DNA replication factor C complex a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle