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Protein Overview: RAP1

General Information:
Name(s) found: RAP1 / YNL216W [SGD]
Description(s) found:
Found 24 descriptions.
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  • DNA-binding protein involved in either activation or repression of transcription, depending on binding site context; also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 827 amino acids

    Gene Ontology:
    Cellular Component: nucleus [TASLink to PubMed article]
    nuclear telomeric heterochromatin [TASLink to PubMed article]
    nuclear telomere cap complex [IDALink to PubMed article]
    Biological Process: protection from non-homologous end joining at telomere [IMPLink to PubMed article]
    transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    telomere maintenance via telomerase [IMPLink to PubMed article]
    chromatin silencing [IMPLink to PubMed article]
    chromatin silencing at telomere [IMPLink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed articleLink to PubMed article]
    transcription factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSPDDFETA PAEYVDALDP SMVVVDSGSA AVTAPSDSAA EVKANQNEEN TGATAAETSE  60
   61 KVDQTEVEKK DDDDTTEVGV TTTTPSIADT AATANIASTS GASVTEPTTD DTAADEKKEQ 120
  121 VSGPPLSNMK FYLNRDADAH DSLNDIDQLA RLIRANGGEV LDSKPRESKE NVFIVSPYNH 180
  181 TNLPTVTPTY IKACCQSNSL LNMENYLVPY DNFREVVDSR LQEESHSNGV DNSNSNSDNK 240
  241 DSIRPKTEII STNTNGATED STSEKVMVDA EQQARLQEQA QLLRQHVSST ASITSGGHND 300
  301 LVQIEQPQKD TSNNNNSNVN DEDNDLLTQD NNPQTADEGN ASFQAQRSMI SRGALPSHNK 360
  361 ASFTDEEDEF ILDVVRKNPT RRTTHTLYDE ISHYVPNHTG NSIRHRFRVY LSKRLEYVYE 420
  421 VDKFGKLVRD DDGNLIKTKV LPPSIKRKFS ADEDYTLAIA VKKQFYRDLF QIDPDTGRSL 480
  481 ITDEDTPTAI ARRNMTMDPN HVPGSEPNFA AYRTQSRRGP IAREFFKHFA EEHAAHTENA 540
  541 WRDRFRKFLL AYGIDDYISY YEAEKAQNRE PEPMKNLTNR PKRPGVPTPG NYNSAAKRAR 600
  601 NYSSQRNVQP TANAASANAA AAAAAAASNS YAIPENELLD EDTMNFISSL KNDLSNISNS 660
  661 LPFEYPHEIA EAIRSDFSNE DIYDNIDPDT ISFPPKIATT DLFLPLFFHF GSTRQFMDKL 720
  721 HEVISGDYEP SQAEKLVQDL CDETGIRKNF STSILTCLSG DLMVFPRYFL NMFKDNVNPP 780
  781 PNVPGIWTHD DDESLKSNDQ EQIRKLVKKH GTGRMEMRKR FFEKDLL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ABF1 CDC13 FHL1 HEK2 PCC1 RAD5 RAP1 RIF1 SIR4 SLD3 STM1 STN1 TBF1 TEL2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #33 Asynchronous SPB prep Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen TSR4 RAP1 1 Unpublished Fields Lab Data
    View Screen MIG1 RAP1 1 Unpublished Fields Lab Data
    View Screen UTP9 RAP1 1 Unpublished Fields Lab Data
    View Screen GRR1 RAP1 1 Unpublished Fields Lab Data
    View Screen CDC16 RAP1 1 Unpublished Fields Lab Data
    View Screen PEX13 RAP1 1 Unpublished Fields Lab Data
    View Screen REH1 RAP1 1 Unpublished Fields Lab Data
    View Screen IOC4 RAP1 1 Unpublished Fields Lab Data
    View Screen CIN4 RAP1 1 Unpublished Fields Lab Data
    View Screen SPO1 RAP1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RAP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..103] deduced N/A No confident structure predictions are available.
    2 View Details [104..269] ORFEUS 7.52 DNA ligase III alpha
    3 View Details [270..340] deduced N/A No confident structure predictions are available.
    4 View Details [341..444]
    [588..616]    		 PSI-BLAST 1518.0 DNA-binding domain of rap1
    5 View Details [445..587] PSI-BLAST 1518.0 DNA-binding domain of rap1
    6 View Details [617..827] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle