Protein Overview: SSN8

General Information:
Name(s) found:	SSN8 / YNL025C [SGD]
Description(s) found: Found 34 descriptions. SHOW ALL	Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance [SGD]
Organism:	Saccharomyces cerevisiae
Length:	323 amino acids
Gene Ontology:
Cellular Component:	transcription factor complex [TAS]
Biological Process:	negative regulation of transcription from RNA polymerase II promoter [TAS] telomere maintenance [IMP] meiosis [IGI][IMP]
Molecular Function:	cyclin-dependent protein kinase regulator activity [TAS] general RNA polymerase II transcription factor activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGSFWTSTQ RHHWQYTKAS LAKERQKLWL LECQLFPQGL NIVMDSKQNG IEQSITKNIP  60
   61 ITHRDLHYDK DYNLRIYCYF LIMKLGRRLN IRQYALATAH IYLSRFLIKA SVREINLYML 120
  121 VTTCVYLACK VEECPQYIRT LVSEARTLWP EFIPPDPTKV TEFEFYLLEE LESYLIVHHP 180
  181 YQSLKQIVQV LKQPPFQITL SSDDLQNCWS LINDSYINDV HLLYPPHIIA VACLFITISI 240
  241 HGKPTKGSSL ASAASEAIRD PKNSSSPVQI AFNRFMAESL VDLEEVMDTI QEQITLYDHW 300
  301 DKYHEQWIKF LLHTLYLRPA SAI

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	(MIPS) Mewes HW, et al. (2004)		SRB8 SSN2 SSN3 SSN8
View Details	Krogan NJ, et al. (2006)		CSE2 DSS1 GAL11 GPT2 IRC11 MED1 MED11 MED2 MED4 MED6 MED7 MED8 NUT1 NUT2 PGD1 RGR1 ROX3 SIN4 SOH1 SRB2 SRB4 SRB5 SRB6 SRB7 SSN3 SSN8 THI72
View Details	Gavin AC, et al. (2002)		ADA2 ADH1 COG3 CSE2 ENO2 FAB1 FBA1 GAL11 GCN5 MED1 MED11 MED2 MED4 MED6 MED7 MED8 MLP1 MRPL6 NUT1 NUT2 PGD1 PGK1 RGR1 ROX3 RPG1 RPO21 SIN4 SPT7 SRB2 SRB4 SRB5 SRB6 SRB7 SRB8 SRP1 SSE2 SSN2 SSN3 SSN8 TAF6 TIF1, TIF2 YIL077C
View Details	Ho Y, et al. (2002)		BCY1 CAR2 CYS4 GND1 GTO1 LAA1 LYS1 SAH1 SNO2 SSN8 THI22 THO2 TIF1, TIF2 TPK2 TPK3 VPS21 YBR028C YCK1 YCK2 YCK3 YGR111W YPT53
View Details	Qiu et al. (2008)		SSN8 TFB5

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CCE1	SSN8	1	Unpublished Fields Lab Data
View Screen	ELM1	SSN8	1	Unpublished Fields Lab Data
View Screen	YNL260C	SSN8	1	Unpublished Fields Lab Data
View Screen	NOB1	SSN8	1	Unpublished Fields Lab Data
View Screen	PNO1	SSN8	1	Unpublished Fields Lab Data
View Screen	GIR2	SSN8	1	Unpublished Fields Lab Data
View Screen	SEC5	SSN8	1	Unpublished Fields Lab Data
View Screen	YDR266C	SSN8	1	Unpublished Fields Lab Data
View Screen	RAD51	SSN8	1	Unpublished Fields Lab Data
View Screen	RAD6	SSN8	1	Unpublished Fields Lab Data
View Screen	TAM41	SSN8	1	Unpublished Fields Lab Data
View Screen	CIC1	SSN8	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	SSN8	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..178] [280..323]	PSI-BLAST	125.522879	Cyclin H (mcs2)
2	View Details	[179..279]	PSI-BLAST	125.522879	Cyclin H (mcs2)

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.75

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2