Protein Overview: RCO1

General Information:
Name(s) found:	RCO1 / YMR075W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|763022\|emb\|CAA88800.1\| unknown [Saccharomyces cerevisiae] [NCBI NR] gi\|6323720\|ref\|NP_013791.1\| Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p; Rco1p [Saccharomyces cerevisiae] [NCBI NR] gi\|2497139\|sp\|Q04779.1\|RCO1_YEAST RecName: Full=Transcriptional regulatory protein RCO1 [NCBI NR] pir\|\|S52835 hypothetical protein YMR075w - yeast (Saccharomyces cerevisiae) [NCBI NR] (Q04779) Hypothetical 78.8 kDa protein in ABF2-CHL12 intergenic region [Swiss-Prot] Transcriptional regulatory protein RCO1 OS=Saccharomyces cerevisiae GN=RCO1 PE=1 SV=1 [Swiss-Prot] RCO1 Protein of unknown function [mips] Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p [SGD] YMR075W, Chr XIII from 413981-416035 [yeast_orfs2] Chr XIII from 413981-416035 [yeastorf3.fasta] RCO1 SGDID:S0004680, Chr XIII from 413981-416035, Uncharacterized ORF [yeastflysequest.fasta] Rco1p [Saccharomyces cerevisiae]gi\|763022\|emb\|CAA88800.1\| unknown [Saccharomyces cerevisiae]gi\|2497139\|sp\|Q04779\|YMW5_YEAST Hypothetical 78.8 kDa protein in ABF2-CHL12 intergenic regiongi\|1078003\|pir\|\|S52835 hypothetical protein YMR075w - yeast (Saccha [nrdb_11152004_Chlamydomonas] YMR075W SGDID:S000004680, Chr XIII from 413981-416035, Uncharacterized ORF, "Nuclear protein of unknown function" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] RCO1 SGDID:S000004680, Chr XIII from 413981-416035, Verified ORF, "Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p" [yeast-contam.fasta] Transcriptional regulatory protein RCO1 [nr-271106-contam.fasta] unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p; Rco1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] Transcriptional regulatory protein RCO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RCO1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] RCO1 SGDID:S000004680, Chr XIII from 413982-416036, Genome Release 64-1-1, Verified ORF, "Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p" [yeast-030211-contam.fasta] RCO1 SGDID:S000004680, Chr XIII from 413982-416036, Genome Release 64-2-1, Verified ORF, "Essential component of the Rpd3S histone deacetylase complex; interacts with Eaf3p" [20141208_orf_trans.fasta] YMR075W SGDID:S000004680, Chr XIII from 413982-416036, Genome Release 64-1-1, Verified ORF, "Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	684 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] histone deacetylase complex [IDA]
Biological Process:	histone deacetylation [IMP]
Molecular Function:	histone deacetylase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTSKKDTTR SPSHSNSSSP SSSSLSSSSS KEKKRPKRLS SQNVNYDLKR RKIITSEGIE  60
   61 RSFKNEHSNL AVEDNIPEEE PKELLEKDSK GNIIKLNEPS TISEDSKVSV TGLPLNKGPS 120
  121 EKIKRESLWN YRKNLGGQSN NSEMTLVPSK RFTQVPKNFQ DLNRNDLKTF LTENMTEESN 180
  181 IRSTIGWNGD IINRTRDREP ESDRDNKKLS NIRTKIILST NATYDSKSKL FGQNSIKSTS 240
  241 NASEKIFRDK NNSTIDFENE DFCSACNQSG SFLCCDTCPK SFHFLCLDPP IDPNNLPKGD 300
  301 WHCNECKFKI FINNSMATLK KIESNFIKQN NNVKIFAKLL FNIDSHNPKQ FQLPNYIKET 360
  361 FPAVKTGSRG QYSDENDKIP LTDRQLFNTS YGQSITKLDS YNPDTHIDSN SGKFLICYKC 420
  421 NQTRLGSWSH PENSRLIMTC DYCQTPWHLD CVPRASFKNL GSKWKCPLHS PTKVYKKIHH 480
  481 CQEDNSVNYK VWKKQRLINK KNQLYYEPLQ KIGYQNNGNI QIIPTTSHTD YDFNQDFKIT 540
  541 QIDENSIKYD FFDKIYKSKM VQKRKLFQFQ ESLIDKLVSN GSQNGNSEDN MVKDIASLIY 600
  601 FQVSNNDKSS NNKSASKSNN LRKLWDLKEL TNVVVPNELD SIQFNDFSSD EIKHLLYLKK 660
  661 IIESKPKEEL LKFLNIENPE NQSE

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		CTI6 DEP1 EAF3 PHO23 RCO1 RPD3 RXT2 SAP30 SDS3 SIN3 UME1
View Details	Krogan NJ, et al. (2006)		ASH1 COQ6 CTI6 DEP1 EAF3 GRX5 PHO23 RCO1 RPD3 RXT2 RXT3 SAP30 SAY1 SDS3 SIN3 UME1
View Details	Gavin AC, et al. (2006)		CTI6 RCO1 RPD3 RXT3 SAP30 SDS3 SIN3 UME1
View Details	Gavin AC, et al. (2002)		ABF2 CKA1 CKA2 CKB1 CKB2 CTI6 DEP1 DOT6 EAF3 ECM16 HTA2 IOC3 ISW1 MED4 NHP10 NRD1 PHO23 RCO1 RPD3 RSC8 RXT2 RXT3 SAP30 SDS3 SIN3 STO1 TOP1 TUP1 UME1 UME6 VPS1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	MLP2	#10 Mitotic Prep1-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	ZIM17	RCO1	2	Unpublished Fields Lab Data
View Screen	VPS5	RCO1	2	Unpublished Fields Lab Data
View Screen	MDM30	RCO1	1	Unpublished Fields Lab Data
View Screen	UBC7	RCO1	1	Unpublished Fields Lab Data
View Screen	KRI1	RCO1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	RCO1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..215]	MSA	9.220997	View MSA. No confident structure predictions are available.
2	View Details	[216..311]	PSI-BLAST	8.30103	Nuclear corepressor KAP-1 (TIF-1beta)
3	View Details	[312..422]	deduced	N/A	No confident structure predictions are available.
4	View Details	[423..484]	PSI-BLAST	51.94696	Williams-Beuren syndrome transcription factor, WSTF
5	View Details	[485..684]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.96

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2