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Protein Overview: ERG6

General Information:
Name(s) found: ERG6 / YML008C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to both lipid particles and mitochondrial outer membrane [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 383 amino acids

    Gene Ontology:
    Cellular Component: lipid particle [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    endoplasmic reticulum [TAS]
    mitochondrial outer membrane [IDALink to PubMed article]
    Biological Process: ergosterol biosynthetic process [TAS]
    Molecular Function: sterol 24-C-methyltransferase activity [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSETELRKRQ AQFTRELHGD DIGKKTGLSA LMSKNNSAQK EAVQKYLRNW DGRTDKDAEE  60
   61 RRLEDYNEAT HSYYNVVTDF YEYGWGSSFH FSRFYKGESF AASIARHEHY LAYKAGIQRG 120
  121 DLVLDVGCGV GGPAREIARF TGCNVIGLNN NDYQIAKAKY YAKKYNLSDQ MDFVKGDFMK 180
  181 MDFEENTFDK VYAIEATCHA PKLEGVYSEI YKVLKPGGTF AVYEWVMTDK YDENNPEHRK 240
  241 IAYEIELGDG IPKMFHVDVA RKALKNCGFE VLVSEDLADN DDEIPWYYPL TGEWKYVQNL 300
  301 ANLATFFRTS YLGRQFTTAM VTVMEKLGLA PEGSKEVTAA LENAAVGLVA GGKSKLFTPM 360
  361 MLFVARKPEN AETPSQTSQE ATQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CAF4 ECM27 ERG6 MTF1 PZF1
    View Details Ho Y, et al. (2002) AAT2 ACH1 ACO1 AFR1 AHP1 ARC1 ARF1 ATP3 CAR2 CDC33 CLU1 COF1 COR1 CPR1 CYR1 CYS4 EGD1 ERG13 ERG6 FPR1 FRS2 GND1 GND2 GRX1 GUS1 HEF3 HHF1, HHF2 LRO1 LSP1 MET6 NTF2 OLA1 OYE2 PFK1 PIL1 PRM2 RNR2 RSN1 SAH1 SCP160 SEC53 SEN15 SES1 SNU13 SOD1 TEF4 THS1 TIF1, TIF2 TMA19 TSA2 UBA1 VMA4 VMA5 WTM1 YNK1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data BSC2 and ERG6 Huh WK, et al. (2003)
    View Data PDR16 and ERG6 Huh WK, et al. (2003)
    View Data ERG6 Huh WK, et al. (2003)
    View Data OSW5 and ERG6 Huh WK, et al. (2003)
    View Data LDB16 and ERG6 Huh WK, et al. (2003)
    View Data COY1 and ERG6 Huh WK, et al. (2003)
    View Data ERG7 and ERG6 Huh WK, et al. (2003)
    View Data RRT8 and ERG6 Huh WK, et al. (2003)
    View Data ERG27 and ERG6 Huh WK, et al. (2003)
    View Data HFD1 and ERG6 Huh WK, et al. (2003)
    View Data SNA2 and ERG6 Huh WK, et al. (2003)
    View Data YOR246C and ERG6 Huh WK, et al. (2003)
    View Data TGL4 and ERG6 Huh WK, et al. (2003)
    View Data TGL3 and ERG6 Huh WK, et al. (2003)
    View Data USE1 and ERG6 Huh WK, et al. (2003)
    View Data SNX41 and ERG6 Huh WK, et al. (2003)
    View Data CST26 and ERG6 Huh WK, et al. (2003)
    View Data YEH1 and ERG6 Huh WK, et al. (2003)
    View Data ERG6 and ERG6 Huh WK, et al. (2003)
    View Data PET10 and ERG6 Huh WK, et al. (2003)
    View Data SSO1 and ERG6 Huh WK, et al. (2003)
    View Data TGL5 and ERG6 Huh WK, et al. (2003)
    View Data FAA4 and ERG6 Huh WK, et al. (2003)
    View Data FAT1 and ERG6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..82]
    [229..248]
    [295..334]    		 PSI-BLAST 52.30103 CmaA1
    2 View Details [83..228]
    [249..294]
    [335..383]    		 PSI-BLAST 52.30103 CmaA1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • transferase activity
    		•  1.07321114919891 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  0.644010137949015 bayes_pls_golite062009
  • methyltransferase activity
    		•  0.635463629299812 bayes_pls_golite062009
  • binding
    		•  0.422181371325275 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  0.181420092548185 bayes_pls_golite062009
  • DNA binding
    		•  0.00720144044916005 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle