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Protein Overview: ERG7

General Information:
Name(s) found: ERG7 / YHR072W [SGD]
Description(s) found:
Found 13 descriptions.
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  • Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 731 amino acids

    Gene Ontology:
    Cellular Component: lipid particle [IDALink to PubMed article]
    endoplasmic reticulum [TAS]
    plasma membrane [TASLink to PubMed article]
    Biological Process: ergosterol biosynthetic process [TAS]
    Molecular Function: lanosterol synthase activity [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEFYSDTIG LPKTDPRLWR LRTDELGRES WEYLTPQQAA NDPPSTFTQW LLQDPKFPQP  60
   61 HPERNKHSPD FSAFDACHNG ASFFKLLQEP DSGIFPCQYK GPMFMTIGYV AVNYIAGIEI 120
  121 PEHERIELIR YIVNTAHPVD GGWGLHSVDK STVFGTVLNY VILRLLGLPK DHPVCAKARS 180
  181 TLLRLGGAIG SPHWGKIWLS ALNLYKWEGV NPAPPETWLL PYSLPMHPGR WWVHTRGVYI 240
  241 PVSYLSLVKF SCPMTPLLEE LRNEIYTKPF DKINFSKNRN TVCGVDLYYP HSTTLNIANS 300
  301 LVVFYEKYLR NRFIYSLSKK KVYDLIKTEL QNTDSLCIAP VNQAFCALVT LIEEGVDSEA 360
  361 FQRLQYRFKD ALFHGPQGMT IMGTNGVQTW DCAFAIQYFF VAGLAERPEF YNTIVSAYKF 420
  421 LCHAQFDTEC VPGSYRDKRK GAWGFSTKTQ GYTVADCTAE AIKAIIMVKN SPVFSEVHHM 480
  481 ISSERLFEGI DVLLNLQNIG SFEYGSFATY EKIKAPLAME TLNPAEVFGD IMVEYPYVEC 540
  541 TDSSVLGLTY FHKYFDYRKE EIRTRIRIAI EFIKKSQLPD GSWYGSWGIC FTYAGMFALE 600
  601 ALHTVGETYE NSSTVRKGCD FLVSKQMKDG GWGESMKSSE LHSYVDSEKS LVVQTAWALI 660
  661 ALLFAEYPNK EVIDRGIDLL KNRQEESGEW KFESVEGVFN HSCAIEYPSY RFLFPIKALG 720
  721 MYSRAYETHT L

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ERG7 YEH1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ERG7 and ERG6 Huh WK, et al. (2003)
    View Data ERG7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..80]
    [564..731]    		 PSI-BLAST 377.54902 Squalene-hopene cyclase
    2 View Details [81..100]
    [386..514]
    [534..563]    		 PSI-BLAST 377.54902 Squalene-hopene cyclase
    3 View Details [101..207]
    [254..284]    		 PSI-BLAST 377.54902 Squalene-hopene cyclase
    4 View Details [208..253]
    [285..385]
    [515..533]    		 PSI-BLAST 377.54902 Squalene-hopene cyclase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • lanosterol synthase activity
    		•  3.72954210081462 bayes_pls_golite062009
  • oxidosqualene cyclase activity
    		•  3.70516211286781 bayes_pls_golite062009
  • prenyltransferase activity
    		•  3.525366989371 bayes_pls_golite062009
  • isoprenoid binding
    		•  1.59014951619756 bayes_pls_golite062009
  • binding
    		•  0.663474225223042 bayes_pls_golite062009
  • protein prenyltransferase activity
    		•  0.55742738134604 bayes_pls_golite062009
  • catalytic activity
    		•  0.497699107100544 bayes_pls_golite062009
  • protein binding
    		•  0.172880799019885 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle