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View Structure Prediction Details

Protein: ERG7
Organism: Saccharomyces cerevisiae
Length: 731 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ERG7.

Description E-value Query
Range		 Subject
Range
CAS1_GLYGL - Cycloartenol synthase OS=Glycyrrhiza glabra GN=GgCAS1 PE=1 SV=1
 0.0 [11..726] [7..753]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [11..724] [7..751]
CAS1_PANGI - Cycloartenol Synthase OS=Panax ginseng GN=OSCPNX1 PE=1 SV=1
 0.0 [11..726] [7..753]
CAS1_ARATH - Cycloartenol synthase OS=Arabidopsis thaliana GN=CAS1 PE=1 SV=2
 0.0 [11..726] [7..753]
CAS2_BETPL - Cycloartenol synthase 2 OS=Betula platyphylla GN=CASBPX2 PE=1 SV=1
 0.0 [11..726] [7..753]

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Predicted Domain #1
Region A:
Residues: [1-80] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEFYSDTIG LPKTDPRLWR LRTDELGRES WEYLTPQQAA NDPPSTFTQW LLQDPKFPQP  60
   61 HPERNKHSPD FSAFDACHNG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [564-731] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TRIRIAIEFI KKSQLPDGSW YGSWGICFTY AGMFALEALH TVGETYENSS TVRKGCDFLV  60
   61 SKQMKDGGWG ESMKSSELHS YVDSEKSLVV QTAWALIALL FAEYPNKEVI DRGIDLLKNR 120
  121 QEESGEWKFE SVEGVFNHSC AIEYPSYRFL FPIKALGMYS RAYETHTL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 377.54902
Match: 1sqc__
Description: Squalene-hopene cyclase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
lanosterol synthase activity 3.72954210081462 bayes_pls_golite062009
oxidosqualene cyclase activity 3.70516211286781 bayes_pls_golite062009
prenyltransferase activity 3.525366989371 bayes_pls_golite062009
isoprenoid binding 1.59014951619756 bayes_pls_golite062009
binding 0.663474225223042 bayes_pls_golite062009
protein prenyltransferase activity 0.55742738134604 bayes_pls_golite062009
catalytic activity 0.497699107100544 bayes_pls_golite062009
protein binding 0.172880799019885 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [81-100] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASFFKLLQEP DSGIFPCQYK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [386-514] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVQTWDCAFA IQYFFVAGLA ERPEFYNTIV SAYKFLCHAQ FDTECVPGSY RDKRKGAWGF  60
   61 STKTQGYTVA DCTAEAIKAI IMVKNSPVFS EVHHMISSER LFEGIDVLLN LQNIGSFEYG 120
  121 SFATYEKIK

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [534-563] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EYPYVECTDS SVLGLTYFHK YFDYRKEEIR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 377.54902
Match: 1sqc__
Description: Squalene-hopene cyclase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [101-207] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPMFMTIGYV AVNYIAGIEI PEHERIELIR YIVNTAHPVD GGWGLHSVDK STVFGTVLNY  60
   61 VILRLLGLPK DHPVCAKARS TLLRLGGAIG SPHWGKIWLS ALNLYKW

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [254-284] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTPLLEELRN EIYTKPFDKI NFSKNRNTVC G

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 377.54902
Match: 1sqc__
Description: Squalene-hopene cyclase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [208-253] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGVNPAPPET WLLPYSLPMH PGRWWVHTRG VYIPVSYLSL VKFSCP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [285-385] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VDLYYPHSTT LNIANSLVVF YEKYLRNRFI YSLSKKKVYD LIKTELQNTD SLCIAPVNQA  60
   61 FCALVTLIEE GVDSEAFQRL QYRFKDALFH GPQGMTIMGT N

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [515-533] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APLAMETLNP AEVFGDIMV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 377.54902
Match: 1sqc__
Description: Squalene-hopene cyclase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle