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Protein Overview: TGL3

General Information:
Name(s) found: TGL3 / YMR313C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 642 amino acids

    Gene Ontology:
    Cellular Component: lipid particle [IDALink to PubMed articleLink to PubMed article]
    Biological Process: lipid metabolic process [IMPLink to PubMed article]
    triglyceride catabolic process [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: triglyceride lipase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKETAQEYKV SAVIPTLLKN WILRVVYATL DHIPPFVWEI LHVITDIYFF WVQKLINYVR  60
   61 PHSRVIYYNA IKKLDECDTY QMWCQQASVV DEITGANLWR RNFFSRRYDF NSVIEQYSIL 120
  121 ENMLREEKYD VVKEKFSTTG PCMLRNFAGI GDKKLFTKSL MGTKLLIEQY LTRILEGLDI 180
  181 LNNQTLTPTS FFQRCKLSLG TTALILQGGS LFGLFHLGVI RGLLLQDLMP NIISGSSMGA 240
  241 CVASLFGCLS NEQLKQLLTD DNLLNIIKND VDLLKSCGYG NLEQHLNLGT LIQNLIHHGY 300
  301 SQDVYLFIRF VMKYIVKEKT FEEVYQITGK VFNIVIHPTD KSCPNLLNYV TTPNVLIKSA 360
  361 IECSLGSGVI SEDTSLLCKN LENEIEPFLN INKNKQVKFL TPENANNPSI TESPYTRLTE 420
  421 LFNVNNFIVS LARPYLAPLV VNDLKHEIKT SKYYYYKHYP NMPPINANTV RKTQRSSSQS 480
  481 PIKAGTVEDL EPEPLMSPVP PSSAVNDSAE YIIPELGIPQ LNFTEMEPLA FKFKYHLERK 540
  541 LKNIATMEFR HRMEVLDNLG LLCSLIKRLI IDEKTPRSAT EIAVVPRMKS LSLTRIIEGQ 600
  601 LNNIPYWIKS GERSTWPALA LIKTRCAVEF KLDDIIRARR SR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) TGL1 TGL3 TGL4 TGL5 YEH1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data TGL3 and ERG6 Huh WK, et al. (2003)
    View Data TGL3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..185] MSA 2.048951 View MSA. No confident structure predictions are available.
    2 View Details [186..412] Pfam 5.443697 Patatin-like phospholipase No confident structure predictions are available.
    3 View Details [413..642] deduced N/A No confident structure predictions are available.
    4 View Details [413..507] deduced N/A No confident structure predictions are available.
    5 View Details [508..642] MSA 1.007981 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • phospholipase A2 activity
    		•  2.22630563405125 bayes_pls_golite062009
  • phospholipase activity
    		•  2.02363770793596 bayes_pls_golite062009
  • lipase activity
    		•  1.83391969295473 bayes_pls_golite062009
  • catalytic activity
    		•  1.681309422157 bayes_pls_golite062009
  • [acyl-carrier-protein] S-malonyltransferase activity
    		•  1.27314027329282 bayes_pls_golite062009
  • S-malonyltransferase activity
    		•  1.27314027329282 bayes_pls_golite062009
  • malonyltransferase activity
    		•  1.27314027329282 bayes_pls_golite062009
  • hydrolase activity
    		•  0.755660272658182 bayes_pls_golite062009
  • fatty acid synthase activity
    		•  0.432469017757431 bayes_pls_golite062009
  • carboxylesterase activity
    		•  0.431665185524913 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.39017969987234 bayes_pls_golite062009
  • S-acyltransferase activity
    		•  0.28475890150768 bayes_pls_golite062009
  • binding
    		•  0.112552746544258 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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