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Protein Overview: NMA1

General Information:
Name(s) found: NMA1 / YLR328W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 401 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: NAD metabolic process [TASLink to PubMed article]
    Molecular Function: nicotinamide-nucleotide adenylyltransferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPTRAPDFK PPSADEELIP PPDPESKIPK SIPIIPYVLA DANSSIDAPF NIKRKKKHPK  60
   61 HHHHHHHSRK EGNDKKHQHI PLNQDDFQPL SAEVSSEDDD ADFRSKERYG SDSTTESETR 120
  121 GVQKYQIADL EEVPHGIVRQ ARTLEDYEFP SHRLSKKLLD PNKLPLVIVA CGSFSPITYL 180
  181 HLRMFEMALD AISEQTRFEV IGGYYSPVSD NYQKQGLAPS YHRVRMCELA CERTSSWLMV 240
  241 DAWESLQPSY TRTAKVLDHF NHEINIKRGG VATVTGEKIG VKIMLLAGGD LIESMGEPNV 300
  301 WADADLHHIL GNYGCLIVER TGSDVRSFLL SHDIMYEHRR NILIIKQLIY NDISSTKVRL 360
  361 FIRRAMSVQY LLPNSVIRYI QEHRLYVDQT EPVKQVLGNK E

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) NMA1 NMA2
    View Details Krogan NJ, et al. (2006) NMA1 NMA2
    View Details Ho Y, et al. (2002) APL2 APL4 APM1 BRX1 CIC1 KRI1 KRR1 NMA1 NOG1 NOP4 PAB1 PWP1 RCL1 TIF6 TUF1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PRR1 NMA1 1 Unpublished Fields Lab Data
    View Screen LOS1 NMA1 1 Unpublished Fields Lab Data
    View Screen CTF13 NMA1 1 Unpublished Fields Lab Data
    View Screen YIF1 NMA1 1 Unpublished Fields Lab Data
    View Screen MPD2 NMA1 1 Unpublished Fields Lab Data
    View Screen STE50 NMA1 1 Unpublished Fields Lab Data
    View Screen IRE1 NMA1 1 Unpublished Fields Lab Data
    View Screen IRE1 NMA1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NMA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..111] deduced N/A No confident structure predictions are available.
    2 View Details [112..401] PSI-BLAST 561.165202 Nicotinamide mononucleotide (NMN) adenylyltransferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  5.66762539052452 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  5.66762539052452 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  5.65398773296369 bayes_pls_golite062009
  • ligase activity
    		•  4.61911329839139 bayes_pls_golite062009
  • nicotinate-nucleotide adenylyltransferase activity
    		•  2.94996967804011 bayes_pls_golite062009
  • nicotinamide-nucleotide adenylyltransferase activity
    		•  2.8149071156304 bayes_pls_golite062009
  • catalytic activity
    		•  2.37674226834122 bayes_pls_golite062009
  • glutamate-tRNA ligase activity
    		•  2.21467185575886 bayes_pls_golite062009
  • methionine-tRNA ligase activity
    		•  2.14891246680781 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.64840822019417 bayes_pls_golite062009
  • tyrosine-tRNA ligase activity
    		•  1.47110858685627 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.32767284282317 bayes_pls_golite062009
  • binding
    		•  1.11291710031577 bayes_pls_golite062009
  • arginine-tRNA ligase activity
    		•  1.0861830757171 bayes_pls_golite062009
  • adenylyltransferase activity
    		•  1.08055019963499 bayes_pls_golite062009
  • tryptophan-tRNA ligase activity
    		•  0.725178047574893 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.564359271862248 bayes_pls_golite062009
  • pantetheine-phosphate adenylyltransferase activity
    		•  0.454904507512502 bayes_pls_golite062009
  • cysteine-tRNA ligase activity
    		•  0.430902479559327 bayes_pls_golite062009
  • transferase activity
    		•  0.364668631710285 bayes_pls_golite062009
  • pantoate-beta-alanine ligase activity
    		•  0.282286652169846 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle