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Protein Overview: NMA2

General Information:
Name(s) found: NMA2 / YGR010W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Nicotinic acid mononucleotide adenylyltransferase, involved in de novo and salvage synthesis of NAD(+) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 395 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: NAD metabolic process [TASLink to PubMed article]
    Molecular Function: nicotinate-nucleotide adenylyltransferase activity [IGILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPTKAPDFK PPQPNEELQP PPDPTHTIPK SGPIVPYVLA DYNSSIDAPF NLDIYKTLSS  60
   61 RKKNANSSNR MDHIPLNTSD FQPLSRDVSS EEESEGQSNG IDATLQDVTM TGNLGVLKSQ 120
  121 IADLEEVPHT IVRQARTIED YEFPVHRLTK KLQDPEKLPL IIVACGSFSP ITYLHLRMFE 180
  181 MALDDINEQT RFEVVGGYFS PVSDNYQKRG LAPAYHRVRM CELACERTSS WLMVDAWESL 240
  241 QSSYTRTAKV LDHFNHEINI KRGGIMTVDG EKMGVKIMLL AGGDLIESMG EPHVWADSDL 300
  301 HHILGNYGCL IVERTGSDVR SFLLSHDIMY EHRRNILIIK QLIYNDISST KVRLFIRRGM 360
  361 SVQYLLPNSV IRYIQEYNLY INQSEPVKQV LDSKE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) NMA1 NMA2
    View Details Krogan NJ, et al. (2006) NMA1 NMA2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NMA2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..112] deduced N/A No confident structure predictions are available.
    2 View Details [113..395] PSI-BLAST 604.228787 Nicotinamide mononucleotide (NMN) adenylyltransferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  5.66762539052452 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  5.66762539052452 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  5.65398773296369 bayes_pls_golite062009
  • ligase activity
    		•  4.61911329839139 bayes_pls_golite062009
  • nicotinate-nucleotide adenylyltransferase activity
    		•  2.94996967804011 bayes_pls_golite062009
  • nicotinamide-nucleotide adenylyltransferase activity
    		•  2.8149071156304 bayes_pls_golite062009
  • catalytic activity
    		•  2.37674226834122 bayes_pls_golite062009
  • glutamate-tRNA ligase activity
    		•  2.21467185575886 bayes_pls_golite062009
  • methionine-tRNA ligase activity
    		•  2.14891246680781 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.64840822019417 bayes_pls_golite062009
  • tyrosine-tRNA ligase activity
    		•  1.47110858685627 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.32767284282317 bayes_pls_golite062009
  • binding
    		•  1.11291710031577 bayes_pls_golite062009
  • arginine-tRNA ligase activity
    		•  1.0861830757171 bayes_pls_golite062009
  • adenylyltransferase activity
    		•  1.08055019963499 bayes_pls_golite062009
  • tryptophan-tRNA ligase activity
    		•  0.725178047574893 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.564359271862248 bayes_pls_golite062009
  • pantetheine-phosphate adenylyltransferase activity
    		•  0.454904507512502 bayes_pls_golite062009
  • cysteine-tRNA ligase activity
    		•  0.430902479559327 bayes_pls_golite062009
  • transferase activity
    		•  0.364668631710285 bayes_pls_golite062009
  • pantoate-beta-alanine ligase activity
    		•  0.282286652169846 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle