Protein Overview: GSY2

General Information:
Name(s) found:	GSY2 / YLR258W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6323287\|ref\|NP_013359.1\| Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p [NCBI NR] gi\|577179\|gb\|AAB67378.1\| Gsy2p: Glycogen Synthase (UDP-glucose--starch glucosyltransferase) [Saccharomyces cerevisiae] [NCBI NR] gi\|1717973\|sp\|P27472.3\|GYS2_YEAST RecName: Full=Glycogen [starch] synthase isoform 2 [NCBI NR] pir\|\|S51396 glycogen(starch) synthase (EC 2.4.1.11) 2 - yeast (Saccharomyces cerevisiae) [NCBI NR] Glycogen [starch] synthase isoform 2 OS=Saccharomyces cerevisiae GN=GSY2 PE=1 SV=3 [Swiss-Prot] GSY2 UDP-glucose--starch glucosyltransferase, isoform 2 [mips] Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase [SGD] GSY2, Chr XII from 660716-662833 [yeast_orfs2] Chr XII from 660716-662833 [yeastorf3.fasta] GSY2 SGDID:S0004248, Chr XII from 660718-662835, Verified ORF [yeastflysequest.fasta] Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase [Saccharomyces c [nrdb_11152004_Chlamydomonas] GSY2 SGDID:S000004248, Chr XII from 660718-662835, Verified ORF, "Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Gsy2p: Glycogen Synthase (UDP-glucose--starch glucosyltransferase) [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Glycogen [starch] synthase isoform 2 [nr-271106-contam.fasta] Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase; Gsy2p [Saccharo [nr-271106-contam.fasta] GSY2 SGDID:S000004248, Chr XII from 660718-662835, Verified ORF, "Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Glycogen [starch] synthase isoform 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GSY2 PE=1 SV=3 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] GSY2 SGDID:S000004248, Chr XII from 660716-662833, Genome Release 64-1-1, Verified ORF, "Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase" [yeast-030211-contam.fasta] GSY2 SGDID:S000004248, Chr XII from 660716-662833, Genome Release 64-2-1, Verified ORF, "Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase; GSY2 has a paralog, GSY1, that arose from the whole genome duplication; relocalizes from cytoplasm to plasma membrane upon DNA replication stress" [20141208_orf_trans.fasta] YLR258W SGDID:S000004248, Chr XII from 660716-662833, Genome Release 64-1-1, Verified ORF, "Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	705 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA ]
Biological Process:	glycogen biosynthetic process [IGI][IMP][ISS]
Molecular Function:	glycogen (starch) synthase activity [IGI][IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRDLQNHLL FETATEVANR VGGIYSVLKS KAPITVAQYK DHYHLIGPLN KATYQNEVDI  60
   61 LDWKKPEAFS DEMRPVQHAL QTMESRGVHF VYGRWLIEGA PKVILFDLDS VRGYSNEWKG 120
  121 DLWSLVGIPS PENDFETNDA ILLGYTVAWF LGEVAHLDSQ HAIVAHFHEW LAGVALPLCR 180
  181 KRRIDVVTIF TTHATLLGRY LCASGSFDFY NCLESVDVDH EAGRFGIYHR YCIERAAAHS 240
  241 ADVFTTVSQI TAFEAEHLLK RKPDGILPNG LNVIKFQAFH EFQNLHALKK EKINDFVRGH 300
  301 FHGCFDFDLD NTLYFFIAGR YEYKNKGADM FIEALARLNY RLKVSGSKKT VVAFIVMPAK 360
  361 NNSFTVEALK GQAEVRALEN TVHEVTTSIG KRIFDHAIRY PHNGLTTELP TDLGELLKSS 420
  421 DKVMLKRRIL ALRRPEGQLP PIVTHNMVDD ANDLILNKIR QVQLFNSPSD RVKMIFHPEF 480
  481 LNANNPILGL DYDEFVRGCH LGVFPSYYEP WGYTPAECTV MGVPSITTNV SGFGAYMEDL 540
  541 IETNQAKDYG IYIVDRRFKA PDESVEQLVD YMEEFVKKTR RQRINQRNRT ERLSDLLDWK 600
  601 RMGLEYVKAR QLALRRGYPD QFRELVGEEL NDSNMDALAG GKKLKVARPL SVPGSPRDLR 660
  661 SNSTVYMTPG DLGTLQEVNN ADDYFSLGVN PAADDDDDGP YADDS

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		GSY1 GSY2
View Details	Krogan NJ, et al. (2006)		ADE5,7 DAP1 GLG1 GLG2 GSY1 GSY2
View Details	Ho Y, et al. (2002)		ADH4 ADR1 BBC1 BMH1 BNR1 BOI2 BUB3 CPR1 CSR2 CYK3 FPR3 FPR4 GDB1 GIP2 GLC7 GLC8 GPH1 GSY1 GSY2 HTB2 KCS1 MDH1 NTH1 PDC5 Q0092 REG1 SDS22 SOK1 STU1 SVL3 YFR017C YIL028W YPI1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MIH1	control 1	McCusker D, et al (2007)
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	MLP2	#31 Asynchronous Prep (Protease cleavage)	Keck JM, et al. (2011)
View Run	MLP2	#03 Alpha Factor Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	GSY2	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..87]	deduced	N/A	No confident structure predictions are available.
2	View Details	[88..360]	MSA	1.293884	View MSA. No confident structure predictions are available.
3	View Details	[361..450]	MSA	2.911997	View MSA. No confident structure predictions are available.
4	View Details	[451..653]	ORFEUS	7.04	UDP-N-acetylglucosamine 2-epimerase
5	View Details	[654..705]	deduced	N/A	No confident structure predictions are available.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: GSY2

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: