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Protein Overview: RFX1

General Information:
Name(s) found: RFX1 / YLR176C [SGD]
Description(s) found:
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  • gi|6323205|ref|NP_013277.1| Protein involved in DNA damage and replication checkpoint pathway; recruits repressors Tup1p and Cyc8p to promoters of DNA damage-inducible genes; similar to a family of mammalian DNA binding RFX1-4 proteins; Rfx1p [Saccharomyc [NCBI NR]
  • gi|3123263|sp|P48743.2|RFX1_YEAST RecName: Full=RFX-like DNA-binding protein RFX1 [NCBI NR]
  • gi|2340986|gb|AAB67470.1| Ylr176cp [Saccharomyces cerevisiae] [NCBI NR]
  • RFX-like DNA-binding protein RFX1 OS=Saccharomyces cerevisiae GN=RFX1 PE=1 SV=2 [Swiss-Prot]
  • RFX1 Repressor of DNA damage-inducible genes [mips]
  • Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins [SGD]
  • RFX1, Chr XII from 507799-510234, reverse complement [yeast_orfs2]
  • Chr XII from 507799-510234, reverse complement [yeastorf3.fasta]
  • Chr XII from 510234-507799, reverse complement [yeastorf5.fasta]
  • (P48743) RFX-like DNA-binding protein RFX1 [4932.FASTACCERV.txt]
  • RFX1 SGDID:S0004166, Chr XII from 510234-507799, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Protein involved in DNA damage and replication checkpoint pathway; recruits repressors Tup1p and Cyc8p to promoters of DNA damage-inducible genes; similar to a family of mammalian DNA binding RFX1-4 proteins [Saccharomyces cerevisiae]gi|3123263|sp|P48743 [nrdb_11152004_Chlamydomonas]
  • RFX1 SGDID:S000004166, Chr XII from 510234-507799, reverse complement, Verified ORF, "Protein involved in DNA damage and replication checkpoint pathway; recruits repressors Tup1p and Cyc8p to promoters of DNA damage-inducible genes; similar to a family of [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • RFX1 SGDID:S000004166, Chr XII from 510234-507799, reverse complement, Verified ORF, "Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Ylr176cp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • RFX-like DNA-binding protein RFX1 [nr-271106-contam.fasta]
  • Protein involved in DNA damage and replication checkpoint pathway; recruits repressors Tup1p and Cyc8p to promoters of DNA damage-inducible genes; similar to a family of mammalian DNA binding RFX1-4 proteins; Rfx1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • RFX1 SGDID:S000004166, Chr XII from 510234-507799, reverse complement, Verified ORF, "Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins" [yeast-bovrabprots.fasta]
  • RFX1 SGDID:S000004166, Chr XII from 510234-507799, reverse complement, Verified ORF, "Protein involved in DNA damage and replication checkpoint pathway; recruits repressors Tup1p and Cyc8p to promoters of DNA damage-inducible genes; similar to a family of mammalian DNA binding RFX1-4 proteins" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • RFX-like DNA-binding protein RFX1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RFX1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • RFX1 SGDID:S000004166, Chr XII from 510232-507797, Genome Release 64-1-1, reverse complement, Verified ORF, "Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins" [yeast-030211-contam.fasta]
  • RFX1 SGDID:S000004166, Chr XII from 510232-507797, Genome Release 64-2-1, reverse complement, Verified ORF, "Major transcriptional repressor of DNA-damage-regulated genes; recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins" [20141208_orf_trans.fasta]
  • YLR176C SGDID:S000004166, Chr XII from 510232-507797, Genome Release 64-1-1, reverse complement, Verified ORF, "Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 811 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IDALink to PubMed article]
    DNA damage checkpoint [TASLink to PubMed article]
    Molecular Function: specific transcriptional repressor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVIFKERKPT ENLFTRKIPA KYFIFSPSFL SVHYFEFYLP MSGDNNIEPT SRGSNDNSNG  60
   61 PSNGSSVNSN RYSLNAPKYS SQPPPASHTY LPPMSVNIPP IASKSSSIYS LLHQSSPRPE 120
  121 TPNPILPPLI GSGPGSHKPS PTPTQPPAQP ATQRQPATYS VYPASISLNR SNSSAYPLSF 180
  181 KSEETLNNNP PTAAKRTNTF PSIPSSTKKQ KTSQEKRISS ISRRNTQEII AKQIAENNKS 240
  241 KTIEEYAQIV KHAEIKVLSM DSQNTSKAAL QLAEQNRERE RQVFALLWLM KNCKSQHDSY 300
  301 VPRGKIFAQY ASSCSQNNLK PLSQASLGKL IRTVFPDLTT RRLGMRGQSK YHYCGLKLTV 360
  361 NESGSVSLNN NNASLSLVHN NDPISPLSSP SPSSPSPQVP NVSSPFSLNR KSLSRTGSPV 420
  421 KQSSNDNPNE PELESQHPNE TEANKLDSLP PAANNPTGTL SSDELTFTHD LIEKVFNCND 480
  481 KLSDNYNTQI LSNTEHPLLT SYKLDFPKIP AGVLPTDTDS DVISSLESLY HIHCNSVYEC 540
  541 IKFLKSDNIS NALFFSNSNS ISPTMFNLFI SEPLIDWVTK CDLITYTGLI KFFSQFIIHS 600
  601 NEISDSIIQK LESMIKLLPE QINKAVLELP KALVQRKLSI INNFTKLVKK LIKLLKFILN 660
  661 FLKSFPIFKS GMNNDWKNIV NLDDILEMMI NEDDTNSETN TIMQHLQGFC QVFVTKFLNS 720
  721 SMSVSNDPSV SIECKSLNEM IKDFCSFISL QSKFSCLKLI DCSTRFRNAI IGDISLKSNE 780
  781 NLLSWLFLNN VMGQLLNYCF EVMKFVNGLK V

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GDH2 RFX1
    View Details Krogan NJ, et al. (2006) ASK10 ATG1 BMH2 KIC1 NTH1 PIK1 REG1 RFX1 SOG2 UBP11 YDR348C YNR014W
    View Details Gavin AC, et al. (2002) ADE5,7 HHF1, HHF2 IOC3 ISW1 ISW2 ITC1 MOT1 NPL6 REB1 RFA1 RFX1 RNR2 RPC34 RPC40 RPO31 RSC2 RSC3 RSC58 RSC8 RVB2 SFH1 STH1 STO1 TAF1 TFC7 TOP1 VPS1 YBR090C-A, NHP6B

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data RFX1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..230] ab initio 12.57 No description for 1deqA was found.
    2 View Details [231..284] deduced N/A No confident structure predictions are available.
    3 View Details [285..360] PSI-BLAST 156.927757 Class II MHC transcription factor RFX1
    4 View Details [361..557] ab initio 11.48 No description for 1i3qA was found.
    5 View Details [558..666] deduced N/A Confident ab initio structure predictions are available.
    6 View Details [667..811] MSA 2.018987 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.61

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle