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Protein Overview: ERG27

General Information:
Name(s) found: ERG27 / YLR100W [SGD]
Description(s) found:
Found 24 descriptions.
SHOW ALL
  • 3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 347 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IDALink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    mitochondrial outer membrane [IDALink to PubMed article]
    Biological Process: ergosterol biosynthetic process [IMPLink to PubMed article]
    Molecular Function: 3-keto sterol reductase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRKVAIVTG TNSNLGLNIV FRLIETEDTN VRLTIVVTSR TLPRVQEVIN QIKDFYNKSG  60
   61 RVEDLEIDFD YLLVDFTNMV SVLNAYYDIN KKYRAINYLF VNAAQGIFDG IDWIGAVKEV 120
  121 FTNPLEAVTN PTYKIQLVGV KSKDDMGLIF QANVFGPYYF ISKILPQLTR GKAYIVWISS 180
  181 IMSDPKYLSL NDIELLKTNA SYEGSKRLVD LLHLATYKDL KKLGINQYVV QPGIFTSHSF 240
  241 SEYLNFFTYF GMLCLFYLAR LLGSPWHNID GYKAANAPVY VTRLANPNFE KQDVKYGSAT 300
  301 SRDGMPYIKT QEIDPTGMSD VFAYIQKKKL EWDEKLKDQI VETRTPI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ARG4 AYR1 COR1 CPR6 ERG27 GPT2 LIA1 MAE1 OM45 PCT1 PDA1 PET10 PET9 PIL1 PRE10 PRO3 RET2 RNR2 RTN2 RVS161 SEC18 SEC21 SEC26 SEC27 SEC28 TIF34 TIF35 TPA1 YNL181W
    View Details Qiu et al. (2008) CYB5 ERG27

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CDC53 ERG27 2 Uetz P, et al. (2000)
    View Screen ERG27 PDR3 2 Unpublished Fields Lab Data
    View Screen ERG27 ERG7 1 Unpublished Fields Lab Data
    View Screen ERG27 YHR130C 1 Unpublished Fields Lab Data
    View Screen ERG27 SVP26 1 Unpublished Fields Lab Data
    View Screen ERG27 IME2 1 Unpublished Fields Lab Data
    View Screen ERG27 KNS1 1 Unpublished Fields Lab Data
    View Screen ERG27 HIF1 1 Unpublished Fields Lab Data
    View Screen UBC7 ERG27 1 Unpublished Fields Lab Data
    View Screen SPT21 ERG27 1 Unpublished Fields Lab Data
    View Screen RAD51 ERG27 1 Unpublished Fields Lab Data
    View Screen ERG27 BOI1 1 Unpublished Fields Lab Data
    View Screen ERG27 DFM1 1 Unpublished Fields Lab Data
    View Screen ERG27 PAN5 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ERG27 Huh WK, et al. (2003)
    View Data ERG27 and ERG6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..347] PSI-BLAST 64.69897 Glucose dehydrogenase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • steroid dehydrogenase activity
    		•  3.70115036051018 bayes_pls_golite062009
  • steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  3.56748749904419 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  2.27417613545298 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.97774592602866 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
    		•  1.03845584151228 bayes_pls_golite062009
  • 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity
    		•  0.744959961067911 bayes_pls_golite062009
  • signal transducer activity
    		•  0.620476349006324 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.620476349006324 bayes_pls_golite062009
  • binding
    		•  0.553666136934364 bayes_pls_golite062009
  • retinol dehydrogenase activity
    		•  0.48259320361048 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.39101464838432 bayes_pls_golite062009
  • receptor activity
    		•  0.0485610523889735 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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