YRC Public Data Repository - Protein Structure Prediction

Protein:	ERG27
Organism:	Saccharomyces cerevisiae
Length:	347 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ERG27.

Description	E-value	Query Range	Subject Range
FABG_THEMA - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima GN=fabG PE=3 SV=1 FABG_THEMA - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima (strain ATCC 43589 / MSB8 / D...	5.0E-70	[1..318]	[3..243]
gi\|18310052, gi\|... - gi\|18310052\|ref\|NP_561986.1\| 3-ketoacyl-(acyl-carrier-protein) reductase [Clostridium perfringens st...	2.0E-69	[1..319]	[2..244]
gi\|25283158 - pir\|\|C83961 3-oxoacyl-(acyl-carrier protein) reductase fabG [imported] - Bacillus halodurans (strain... gi\|10175111, gi\|... - gi\|15615054\|ref\|NP_243357.1\| 3-oxoacyl-(acyl-carrier protein) reductase [Bacillus halodurans C-125],...	8.0E-69	[1..319]	[2..244]
DHB7_RAT - 3-keto-steroid reductase OS=Rattus norvegicus GN=Hsd17b7 PE=1 SV=1	1.0E-68	[3..345]	[2..332]
gi\|61361334, gi\|... - gi\|61361334\|gb\|AAX42032.1\| hydroxysteroid (17-beta) dehydrogenase 7 [synthetic construct], gi\|613613... HGNC:5215\|MIM:60... - (17-beta) dehydrogenase 7, (17-beta) dehydrogenase 7, (17-beta) dehydrogenase 7 HSD17B7 - hydroxysteroid (17-beta) dehydrogenase 7	1.0E-68	[3..344]	[2..331]
gi\|18077845, gi\|... - ref\|NP_034606.2\| hydroxysteroid (17-beta) dehydrogenase 7 [Mus musculus], gi\|18077845\|emb\|CAC88119....	3.0E-68	[3..346]	[2..333]
gi\|1502421 - gi\|1502421\|gb\|AAC44307.1\| 3-ketoacyl-acyl carrier protein reductase gi\|1502421\|gb\|AA... - 3-ketoacyl-acyl carrier protein reductase	5.0E-67	[1..319]	[2..244]
gi\|221313791 - gi\|221313791\|ref\|ZP_03595596.1\| beta-ketoacyl-acyl carrier protein reductase [Bacillus subtilis subs... gi\|221318715 - gi\|221318715\|ref\|ZP_03600009.1\| beta-ketoacyl-acyl carrier protein reductase [Bacillus subtilis subs... gi\|221322986 - gi\|221322986\|ref\|ZP_03604280.1\| beta-ketoacyl-acyl carrier protein reductase [Bacillus subtilis subs... FABG_BACSU - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Bacillus subtilis GN=fabG PE=3 SV=3 FABG_BACSU - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Bacillus subtilis (strain 168) GN=fabG PE=3 SV=3	8.0E-67	[1..319]	[2..244]

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Predicted Domain #1

Region A:
Residues: [1-347]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRKVAIVTG TNSNLGLNIV FRLIETEDTN VRLTIVVTSR TLPRVQEVIN QIKDFYNKSG  60
   61 RVEDLEIDFD YLLVDFTNMV SVLNAYYDIN KKYRAINYLF VNAAQGIFDG IDWIGAVKEV 120
  121 FTNPLEAVTN PTYKIQLVGV KSKDDMGLIF QANVFGPYYF ISKILPQLTR GKAYIVWISS 180
  181 IMSDPKYLSL NDIELLKTNA SYEGSKRLVD LLHLATYKDL KKLGINQYVV QPGIFTSHSF 240
  241 SEYLNFFTYF GMLCLFYLAR LLGSPWHNID GYKAANAPVY VTRLANPNFE KQDVKYGSAT 300
  301 SRDGMPYIKT QEIDPTGMSD VFAYIQKKKL EWDEKLKDQI VETRTPI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	64.69897
Match:	1gcoA_
Description:	Glucose dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
steroid dehydrogenase activity	3.70115036051018	bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	3.56748749904419	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	2.27417613545298	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.97774592602866	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity	1.03845584151228	bayes_pls_golite062009
3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity	0.744959961067911	bayes_pls_golite062009
signal transducer activity	0.620476349006324	bayes_pls_golite062009
molecular transducer activity	0.620476349006324	bayes_pls_golite062009
binding	0.553666136934364	bayes_pls_golite062009
retinol dehydrogenase activity	0.48259320361048	bayes_pls_golite062009
oxidoreductase activity	0.39101464838432	bayes_pls_golite062009
receptor activity	0.0485610523889735	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: