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Protein Overview: PDR3

General Information:
Name(s) found: PDR3 / YBL005W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Transcriptional activator of the pleiotropic drug resistance network, regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 976 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][IPILink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: positive regulation of transcription, DNA-dependent [IDALink to PubMed article]
    response to drug [TASLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [TASLink to PubMed article]
    Molecular Function: DNA binding [IPILink to PubMed article][TASLink to PubMed article]
    transcription activator activity [IDALink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVKKSTRSK VSTACVNCRK RKIKCTGKYP CTNCISYDCT CVFLKKHLPQ KEDSSQSLPT  60
   61 TAVAPPSSHA NVEASADVQH LDTAIKLDNQ YYFKLMNDLI QTPVSPSATH APDTSNNPTN 120
  121 DNNILFKDDS KYQNQLVTYQ NILTNLYALP PCDDTQLLID KTKSQLNNLI NSWNPEINYP 180
  181 KLSSFSPRPQ RSIETYLLTN KYRNKIHMTR FSFWTDQMVK SQSPDSFLAT TPLVDEVFGL 240
  241 FSPIQAFSLR GIGYLIKKNI ENTGSSMLID TKETIYLILR LFDLCYEHLI QGCISISNPL 300
  301 ENYLQKIKQT PTTTASASLP TSPAPLSNDL VISVIHQLPQ PFIQSITGFT TTQLIENLHD 360
  361 SFSMFRIVTQ MYAQHRKRFA EFLNQAFSLP HQEKSVLFSS FCSSEYLLST LCYAYYNVTL 420
  421 YHMLDINTLD YLEILVSLLE IQNEIDERFG FEKMLEVAVT CSTKMGLSRW EYYVGIDENT 480
  481 AERRRKIWWK IYSLEKRFLT DLGDLSLINE HQMNCLLPKD FRDMGFINHK EFLTKIGTSS 540
  541 LSPSSPKLKN LSLSRLIEYG ELAIAQIVGD FFSETLYNEK FTSLEVSVKP TIIRQKLLEK 600
  601 VFEDIESFRL KLAKIKLHTS RVFQVAHCKY PEYPKNDLIE AAKFVSYHKN TWFSILGAVN 660
  661 NLIARLSEDP EVITEQSMKY ANEMFQEWRE INQFLIQVDT DFIVWACLDF YELIFFVMAS 720
  721 KFYVEDPHIT LEDVINTLKV FKRITNIISF FNNNLDEKDY DCQTFREFSR SSSLVAISIR 780
  781 IIFLKYCYAE QIDRAEFIER LKEVEPGLSD LLREFFDTRS FIYRYMLKSV EKSGFHLIIR 840
  841 KMLESDYKFL YRDKLATGNI PDQGNSSQIS QLYDSTAPSY NNASASAANS PLKLSSLLNS 900
  901 GEESYTQDAS ENVPCNLRHQ DRSLQQTKRQ HSAPSQISAN ENNIYNLGTL EEFVSSGDLT 960
  961 DLYHTLWNDN TSYPFL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ARA1 PDR3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen YNL146W PDR3 2 Unpublished Fields Lab Data
    View Screen YIF1 PDR3 2 Unpublished Fields Lab Data
    View Screen VPS68 PDR3 2 Unpublished Fields Lab Data
    View Screen PHS1 PDR3 2 Unpublished Fields Lab Data
    View Screen ERG27 PDR3 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PDR3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..103] PSI-BLAST 46.144602 PUT3
    2 View Details [104..404] deduced N/A No confident structure predictions are available.
    3 View Details [405..538] MSA 9.024997 View MSA. No confident structure predictions are available.
    4 View Details [539..976] deduced N/A No confident structure predictions are available.
    5 View Details [525..754] deduced N/A No confident structure predictions are available.
    6 View Details [755..976] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.56444258780502 bayes_pls_golite062009
  • DNA binding
    		•  4.26146437716972 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.17369933547911 bayes_pls_golite062009
  • transcription factor activity
    		•  3.049435548132 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.98081393153291 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.93914501897006 bayes_pls_golite062009
  • binding
    		•  2.91929847152301 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  2.44382866473054 bayes_pls_golite062009
  • transcription activator activity
    		•  2.24483536326713 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle