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Protein Overview: PHS1

General Information:
Name(s) found: PHS1 / YJL097W [SGD]
Description(s) found:
Found 35 descriptions.
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  • Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 217 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole membrane [IDALink to PubMed article]
    nuclear membrane-endoplasmic reticulum network [IDALink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    fungal-type vacuole [IDALink to PubMed articleLink to PubMed article]
    Biological Process: secretory pathway [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKKLASPLS FLPLYNLLSA VGWSYLLYLV ISLYPKVGQP AFFYQTKNVA TLVQCGAIIE  60
   61 IINSFLGVVR SPLLTTVAQV SSRLLVVLGI FQLLPNTSGV QSVVYISLLL AWSITEIVRY 120
  121 LYYFFMLVFK NGAPKILILL RYNLFWILYP TGVASELRII YCALNAAESQ YSLLYKRILI 180
  181 AAMLAYIPGF PMLFLHMVAQ RKKVMKSLRS SFGKKLI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PHS1 PEX29 2 Unpublished Fields Lab Data
    View Screen PHS1 OLE1 2 Unpublished Fields Lab Data
    View Screen PHS1 PRM3 2 Unpublished Fields Lab Data
    View Screen PHS1 YGR149W 2 Unpublished Fields Lab Data
    View Screen PHS1 MPS3 2 Unpublished Fields Lab Data
    View Screen PHS1 IKS1 2 Unpublished Fields Lab Data
    View Screen PHS1 SPC1 2 Unpublished Fields Lab Data
    View Screen PHS1 PDR3 2 Unpublished Fields Lab Data
    View Screen PHS1 HFD1 2 Unpublished Fields Lab Data
    View Screen PHS1 YDL133W 2 Unpublished Fields Lab Data
    View Screen PHS1 ZRG17 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PHS1 and SPC42 Hazbun TR, et al. (2003)
    View Data PHS1 and TRX3 Hazbun TR, et al. (2003)
    View Data PHS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..129] MSA 2.027991 View MSA. Confident ab initio structure predictions are available.
    2 View Details [130..217] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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