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Protein Overview: OLE1

General Information:
Name(s) found: OLE1 / YGL055W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 510 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [TASLink to PubMed article]
    Biological Process: mitochondrion inheritance [TASLink to PubMed article]
    unsaturated fatty acid biosynthetic process [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: stearoyl-CoA 9-desaturase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTSGTTIEL IDDQFPKDDS ASSGIVDEVD LTEANILATG LNKKAPRIVN GFGSLMGSKE  60
   61 MVSVEFDKKG NEKKSNLDRL LEKDNQEKEE AKTKIHISEQ PWTLNNWHQH LNWLNMVLVC 120
  121 GMPMIGWYFA LSGKVPLHLN VFLFSVFYYA VGGVSITAGY HRLWSHRSYS AHWPLRLFYA 180
  181 IFGCASVEGS AKWWGHSHRI HHRYTDTLRD PYDARRGLWY SHMGWMLLKP NPKYKARADI 240
  241 TDMTDDWTIR FQHRHYILLM LLTAFVIPTL ICGYFFNDYM GGLIYAGFIR VFVIQQATFC 300
  301 INSLAHYIGT QPFDDRRTPR DNWITAIVTF GEGYHNFHHE FPTDYRNAIK WYQYDPTKVI 360
  361 IYLTSLVGLA YDLKKFSQNA IEEALIQQEQ KKINKKKAKI NWGPVLTDLP MWDKQTFLAK 420
  421 SKENKGLVII SGIVHDVSGY ISEHPGGETL IKTALGKDAT KAFSGGVYRH SNAAQNVLAD 480
  481 MRVAVIKESK NSAIRMASKR GEIYETGKFF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CTP1 ERV25 FKS1 FTR1 MRH1 OLE1 PEX27 ROG3 RPL10 RPL36B RPL37A RPP1A SEC11 SPC1 SPC2 SPC3 TCM62 TSC13 YNR021W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIA40 No Comments Hazbun TR, et al. (2003)
    View Run HIR2 No Comments Green EM, et al (2005)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PHS1 OLE1 2 Unpublished Fields Lab Data
    View Screen YIF1 OLE1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data OLE1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..96] MSA 1.067997 View MSA. No confident structure predictions are available.
    2 View Details [97..398] Pfam 74.958607 Fatty acid desaturase No confident structure predictions are available.
    3 View Details [399..510] PSI-BLAST 57.0103 Cytochrome b5
    4 View Details [398..510] PSI-BLAST 29.045757 THE SOLUTION NMR STRUCTURE OF THE B FORM OF OXIDIZED RAT MICROSOMAL CYTOCHROME B5, MINIMIZED AVERAGE STRUCTURE

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • linoleoyl-CoA desaturase activity
    		•  3.07254352516686 bayes_pls_golite062009
  • sterol desaturase activity
    		•  3.07254352516686 bayes_pls_golite062009
  • C-5 sterol desaturase activity
    		•  3.07254352516686 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
    		•  2.29500061324594 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  1.83295508128013 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.42823652075069 bayes_pls_golite062009
  • signal transducer activity
    		•  1.42823652075069 bayes_pls_golite062009
  • binding
    		•  1.13937274704645 bayes_pls_golite062009
  • transporter activity
    		•  0.920087041947819 bayes_pls_golite062009
  • receptor activity
    		•  0.910083764754729 bayes_pls_golite062009
  • electron carrier activity
    		•  0.775128726876733 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.739503099682459 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.583561246970036 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.535501995010142 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.314610777889032 bayes_pls_golite062009
  • protein binding
    		•  0.268795825133297 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.0578908750434612 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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