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Protein Overview: SPC2

General Information:
Name(s) found: SPC2 / YML055W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 178 amino acids

    Gene Ontology:
    Cellular Component: signal peptidase complex [IDALink to PubMed article]
    Biological Process: signal peptide processing [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed articleLink to PubMed article][ISSLink to PubMed article]
    protein targeting to ER [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: protein binding [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSAKPINVY SIPELNQALD EALPSVFARL NYERSYALLD AKLYIGYSIA VVAGLSFFLD  60
   61 KKFERDQIVT YQKLLVGAYF VLSLLFWYFS RFIEKGTVYV GKRRGTKEEI YVKTKFEKNE 120
  121 PLYLVELVQK KKGENSKKEL KAKLEVNKVF NESGYLQNDA YFKWFSEQHN VLDTKKNE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) SPC2 YDR306C
    View Details (MIPS) Mewes HW, et al. (2004) SEC11 SPC1 SPC2
    View Details Krogan NJ, et al. (2006) CTP1 ERV25 FKS1 FTR1 MRH1 OLE1 PEX27 ROG3 RPL10 RPL36B RPL37A RPP1A SEC11 SPC1 SPC2 SPC3 TCM62 TSC13 YNR021W
    View Details Qiu et al. (2008) SBH1 SEC11 SPC1 SPC2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SPC2 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..178] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle