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Protein Overview: SPC3

General Information:
Name(s) found: SPC3 / YLR066W [SGD]
Description(s) found:
Found 34 descriptions.
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  • Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 184 amino acids

    Gene Ontology:
    Cellular Component: signal peptidase complex [IDALink to PubMed article]
    Biological Process: signal peptide processing [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article][IPILink to PubMed article][ISSLink to PubMed articleLink to PubMed article]
    protein targeting to ER [IMPLink to PubMed article]
    Molecular Function: signal peptidase activity [IMPLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFSFVQRFQN VSNQAFSMGI VMVVFIMASS YYQLINNNAF SVPSNIDNVK TLINVRTSRY  60
   61 FGSQRGKAKE NMKIKFDLNT DLTPLFNWNT KQVFVYLTAE YNSTEKITSE VTFWDKIIKS 120
  121 KDDAVIDVND LRSKYSIWDI EDGKFEGKDL VFKLHWNVQP WVGLLTYGET VGNYTLTVEN 180
  181 KNKV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CTP1 ERV25 FKS1 FTR1 MRH1 OLE1 PEX27 ROG3 RPL10 RPL36B RPL37A RPP1A SEC11 SPC1 SPC2 SPC3 TCM62 TSC13 YNR021W
    View Details Qiu et al. (2008) SEC11 SPC1 SPC3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run NOP9 No Comments Hazbun TR, et al. (2003)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SPC3 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..184] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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