Protein Overview: SPC3

General Information:
Name(s) found:	SPC3 / YLR066W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6323095\|ref\|NP_013167.1\| Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23; Spc3p [Saccharomyces ce [NCBI NR] gi\|45270300\|gb\|AAS56531.1\| YLR066W [Saccharomyces cerevisiae] [NCBI NR] gi\|2497628\|sp\|Q12133.1\|SPC3_YEAST RecName: Full=Signal peptidase complex subunit SPC3; AltName: Full=Microsomal signal peptidase subunit 3 [NCBI NR] pir\|\|S61639 probable membrane protein YLR066w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1928971\|gb\|AAB51390.1\| signal peptidase subunit [Saccharomyces cerevisiae] [NCBI NR] gi\|1360416\|emb\|CAA97622.1\| SPC3 [Saccharomyces cerevisiae] [NCBI NR] gi\|1181286\|emb\|CAA64312.1\| L2186 [Saccharomyces cerevisiae] [NCBI NR] Signal peptidase complex subunit SPC3 OS=Saccharomyces cerevisiae GN=SPC3 PE=1 SV=1 [Swiss-Prot] SPC3 Signal peptidase subunit [mips] Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23 [SGD] SPC3, Chr XII from 267170-267724 [yeast_orfs2] Chr XII from 267170-267724 [yeastorf3.fasta] (Q12133) Microsomal signal peptidase subunit 3 (EC 3.4.-.-) [4932.FASTACCERV.txt] SPC3 SGDID:S0004056, Chr XII from 267170-267724, Verified ORF [yeastflysequest.fasta] Spc3p [Saccharomyces cerevisiae]gi\|1360416\|emb\|CAA97622.1\| SPC3 [Saccharomyces cerevisiae]gi\|1181286\|emb\|CAA64312.1\| L2186 [Saccharomyces cerevisiae]gi\|2132675\|pir\|\|S61639 probable membrane protein YLR066w - yeast (Saccharomyces cerevisiae)gi\|45270300 [nrdb_11152004_Chlamydomonas] SPC3 SGDID:S000004056, Chr XII from 267170-267724, Verified ORF, "Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mamma [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] YLR066W [Saccharomyces cerevisiae] [nr-271106-contam.fasta] L2186 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Signal peptidase complex subunit SPC3 (Microsomal signal peptidase subunit 3) [nr-271106-contam.fasta] signal peptidase subunit [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23; Spc3p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] SPC3 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] SPC3 SGDID:S000004056, Chr XII from 267170-267724, Verified ORF, "Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Signal peptidase complex subunit SPC3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPC3 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] SPC3 SGDID:S000004056, Chr XII from 267169-267723, Genome Release 64-1-1, Verified ORF, "Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23" [yeast-030211-contam.fasta] SPC3 SGDID:S000004056, Chr XII from 267169-267723, Genome Release 64-2-1, Verified ORF, "Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23; other members of the complex are Spc1p, Spc2p, and Sec11p" [20141208_orf_trans.fasta] TR6704\|c0_g1_i1\|g.4719 ORF TR6704\|c0_g1_i1\|g.4719 TR6704\|c0_g1_i1\|m.4719 type:complete len:185 (+) TR6704\|c0_g1_i1:119-673(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] TR2271\|c0_g1_i1\|g.1591 ORF TR2271\|c0_g1_i1\|g.1591 TR2271\|c0_g1_i1\|m.1591 type:complete len:185 (+) TR2271\|c0_g1_i1:231-785(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YLR066W SGDID:S000004056, Chr XII from 267169-267723, Genome Release 64-1-1, Verified ORF, "Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_8575\|g.6185 ORF asmbl_8575\|g.6185 asmbl_8575\|m.6185 type:complete len:185 (+) asmbl_8575:229-783(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta] asmbl_8424\|g.6298 ORF asmbl_8424\|g.6298 asmbl_8424\|m.6298 type:complete len:185 (+) asmbl_8424:144-698(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_8388\|g.5233 ORF ID=asmbl_8388\|g.5233 ID=asmbl_8388\|m.5233 type:complete len:185 (+) ID=asmbl_8388:229-783(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta] ID=asmbl_8423\|g.5209 ORF ID=asmbl_8423\|g.5209 ID=asmbl_8423\|m.5209 type:complete len:185 (+) ID=asmbl_8423:144-698(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	184 amino acids
Gene Ontology:
Cellular Component:	signal peptidase complex [IDA]
Biological Process:	signal peptide processing [IDA][IGI][IMP ][IPI][ISS ] protein targeting to ER [IMP]
Molecular Function:	signal peptidase activity [IMP ]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFSFVQRFQN VSNQAFSMGI VMVVFIMASS YYQLINNNAF SVPSNIDNVK TLINVRTSRY  60
   61 FGSQRGKAKE NMKIKFDLNT DLTPLFNWNT KQVFVYLTAE YNSTEKITSE VTFWDKIIKS 120
  121 KDDAVIDVND LRSKYSIWDI EDGKFEGKDL VFKLHWNVQP WVGLLTYGET VGNYTLTVEN 180
  181 KNKV

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		CTP1 ERV25 FKS1 FTR1 MRH1 OLE1 PEX27 ROG3 RPL10 RPL36B RPL37A RPP1A SEC11 SPC1 SPC2 SPC3 TCM62 TSC13 YNR021W
View Details	Qiu et al. (2008)		SEC11 SPC1 SPC3

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	NOP9	No Comments	Hazbun TR, et al. (2003)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	SPC3	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..184]	deduced	N/A	No confident structure predictions are available.

Protein Overview: SPC3

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: