Protein Overview: SPC3

General Information:
Name(s) found:	SPC3 / YLR066W [SGD]
Description(s) found: Found 34 descriptions. SHOW ALL	Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23 [SGD]
Organism:	Saccharomyces cerevisiae
Length:	184 amino acids
Gene Ontology:
Cellular Component:	signal peptidase complex [IDA]
Biological Process:	signal peptide processing [IDA][IGI][IMP ][IPI][ISS ] protein targeting to ER [IMP]
Molecular Function:	signal peptidase activity [IMP ]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFSFVQRFQN VSNQAFSMGI VMVVFIMASS YYQLINNNAF SVPSNIDNVK TLINVRTSRY  60
   61 FGSQRGKAKE NMKIKFDLNT DLTPLFNWNT KQVFVYLTAE YNSTEKITSE VTFWDKIIKS 120
  121 KDDAVIDVND LRSKYSIWDI EDGKFEGKDL VFKLHWNVQP WVGLLTYGET VGNYTLTVEN 180
  181 KNKV

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		CTP1 ERV25 FKS1 FTR1 MRH1 OLE1 PEX27 ROG3 RPL10 RPL36B RPL37A RPP1A SEC11 SPC1 SPC2 SPC3 TCM62 TSC13 YNR021W
View Details	Qiu et al. (2008)		SEC11 SPC1 SPC3

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	NOP9	No Comments	Hazbun TR, et al. (2003)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	UBC6	SPC3	1	Unpublished Fields Lab Data
View Screen	YHR122W	SPC3	1	Hazbun TR, et al. (2003)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	SPC3	Huh WK, et al. (2003)

Protein Structure Data

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Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..184]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2