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View Structure Prediction Details

Protein: OLE1
Organism: Saccharomyces cerevisiae
Length: 510 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for OLE1.

Description E-value Query
Range
Subject
Range
ACO1_YEAST - Acyl-CoA desaturase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=OLE1 PE=1 SV=2
OLE1 - Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal dis...
0.0 [1..510] [1..510]
gi|19570824 - gi|19570824|dbj|BAB86330.1| delta 9-fatty acid desaturase [Lachancea kluyveri]
0.0 [26..508] [1..478]
gi|4520356 - gi|4520356|dbj|BAA75902.1| delta9-fatty acid desaturase [Pichia angusta]
0.0 [56..489] [1..429]
gi|4521097, gi|4... - gi|4521099|dbj|BAA75928.1| delta-9 fatty acid desaturase [Mortierella alpina], gi|4521097|dbj|BAA759...
0.0 [83..507] [17..440]
ACO1_SCHPO - Probable acyl-CoA desaturase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPCC1281.06c ...
SPCC1281.06c - acyl-coA desaturase
0.0 [62..497] [14..443]
gi|2570906 - gi|2570906|gb|AAB82294.1| delta-9 desaturase [Amylomyces rouxii]
0.0 [75..510] [2..441]

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Predicted Domain #1
Region A:
Residues: [1-96]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTSGTTIEL IDDQFPKDDS ASSGIVDEVD LTEANILATG LNKKAPRIVN GFGSLMGSKE  60
   61 MVSVEFDKKG NEKKSNLDRL LEKDNQEKEE AKTKIH

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [97-398]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISEQPWTLNN WHQHLNWLNM VLVCGMPMIG WYFALSGKVP LHLNVFLFSV FYYAVGGVSI  60
   61 TAGYHRLWSH RSYSAHWPLR LFYAIFGCAS VEGSAKWWGH SHRIHHRYTD TLRDPYDARR 120
  121 GLWYSHMGWM LLKPNPKYKA RADITDMTDD WTIRFQHRHY ILLMLLTAFV IPTLICGYFF 180
  181 NDYMGGLIYA GFIRVFVIQQ ATFCINSLAH YIGTQPFDDR RTPRDNWITA IVTFGEGYHN 240
  241 FHHEFPTDYR NAIKWYQYDP TKVIIYLTSL VGLAYDLKKF SQNAIEEALI QQEQKKINKK 300
  301 KA

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 74.958607
Match: PF00487
Description: Fatty acid desaturase

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [399-510]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KINWGPVLTD LPMWDKQTFL AKSKENKGLV IISGIVHDVS GYISEHPGGE TLIKTALGKD  60
   61 ATKAFSGGVY RHSNAAQNVL ADMRVAVIKE SKNSAIRMAS KRGEIYETGK FF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.0103
Match: 1iccA_
Description: Cytochrome b5
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [398-510]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKINWGPVLT DLPMWDKQTF LAKSKENKGL VIISGIVHDV SGYISEHPGG ETLIKTALGK  60
   61 DATKAFSGGV YRHSNAAQNV LADMRVAVIK ESKNSAIRMA SKRGEIYETG KFF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.045757
Match: 1bfxA
Description: THE SOLUTION NMR STRUCTURE OF THE B FORM OF OXIDIZED RAT MICROSOMAL CYTOCHROME B5, MINIMIZED AVERAGE STRUCTURE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
linoleoyl-CoA desaturase activity 3.07254352516686 bayes_pls_golite062009
sterol desaturase activity 3.07254352516686 bayes_pls_golite062009
C-5 sterol desaturase activity 3.07254352516686 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2.29500061324594 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 1.83295508128013 bayes_pls_golite062009
molecular transducer activity 1.42823652075069 bayes_pls_golite062009
signal transducer activity 1.42823652075069 bayes_pls_golite062009
binding 1.13937274704645 bayes_pls_golite062009
transporter activity 0.920087041947819 bayes_pls_golite062009
receptor activity 0.910083764754729 bayes_pls_golite062009
electron carrier activity 0.775128726876733 bayes_pls_golite062009
transmembrane transporter activity 0.739503099682459 bayes_pls_golite062009
oxidoreductase activity 0.583561246970036 bayes_pls_golite062009
substrate-specific transporter activity 0.535501995010142 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.314610777889032 bayes_pls_golite062009
protein binding 0.268795825133297 bayes_pls_golite062009
ion transmembrane transporter activity 0.0578908750434612 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle