Protein Overview: ARP3

General Information:
Name(s) found:	ARP3 / YJR065C [SGD]
Description(s) found: Found 31 descriptions. SHOW ALL	Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity [SGD]
Organism:	Saccharomyces cerevisiae
Length:	449 amino acids
Gene Ontology:
Cellular Component:	Arp2/3 protein complex [IDA]
Biological Process:	mitochondrion inheritance [TAS] actin filament organization [IMP]
Molecular Function:	ATP binding [IDA][IMP] actin binding [TAS] structural constituent of cytoskeleton [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYLNNPAVV MDNGTGLTKL GFAGNDSPSW VFPTAIATAA PSNTKKSSGV GAPSAVSNEA  60
   61 SYFGNSTSAT NFNGATGGLL SNNLSGKRGT EDLDFYIGNE ALVASQGPSY SLSYPIRHGQ 120
  121 VENWDHMERF WENSIFKYLR TEPEDHFFLL TEPPLNPPEN REQVAEIFFE SFNCAGLYIA 180
  181 VQAVLALAAS WTSSKVTDRS LTGTVIDSGD GVTHVIPVAE GYVIGSAIKN IPIAGRDITL 240
  241 FIQSLLRERG EADTSLRTAE KIKQEYCYVC PDIVKEFNKF DKDPSKFAQF VVENQEKTRR 300
  301 KVVDIGYERF LAPEIFFNPE IASSDFLTPL PTVVDQTIQA CPIDVRKGLY NNIVLSGGST 360
  361 MFKDFGRRLQ RDLKSIVNNR IAQSELLSGT KSTGVDVSVI SHRKQRNAVW FGGSLLAQTA 420
  421 EFKGYCHTKK DYEEYGPEIV RNFSLFNMV

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		ARC15 ARC18 ARC19 ARC35 ARC40 ARP2 ARP3 TWF1
View Details	(MIPS) Mewes HW, et al. (2004)		ARC15 ARC18 ARC19 ARC35 ARP2 ARP3
View Details	Krogan NJ, et al. (2006)		ARC18 ARC19 ARC35 ARC40 ARP2 ARP3 PAC1 TAP42
View Details	Gavin AC, et al. (2006)		ARC15 ARC18 ARC19 ARC35 ARC40 ARP2 ARP3
View Details	Gavin AC, et al. (2002)		ARC15 ARC18 ARC19 ARC35 ARC40 ARP2 ARP3 CCT5 CCT8 NOG2 PFK1 PRT1
View Details	Ho Y, et al. (2002)		ABP1 ADR1 ARC15 ARC18 ARC19 ARC35 ARC40 ARP2 ARP3 ATP3 BNI1 DUR1,2 FET3 GFA1 HXT7 IMH1 KAP122 MCM4 MCM7 MET18 NIP1 NOP4 POB3 PST2 PUF3 RPN8 RPT4 RVB1 SCP1 SPS1 SSZ1 TRP3 TUP1 YJR029W YLR241W YNL040W YSC84
View Details	Qiu et al. (2008)		ACT1 ARC15 ARC18 ARC19 ARP2 ARP3

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	IRE1	ARP3	1	Unpublished Fields Lab Data
View Screen	CUS1	ARP3	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..182] [409..449]	PSI-BLAST	1682.218487	Actin
2	View Details	[183..408]	PSI-BLAST	1682.218487	Actin

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.83

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2