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Protein Overview: GND2

General Information:
Name(s) found: GND2 / YGR256W [SGD]
Description(s) found:
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  • gi|6321695|ref|NP_011772.1| 6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; Gnd2p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|51013073|gb|AAT92830.1| YGR256W [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S64588 phosphogluconate dehydrogenase (decarboxylating) (EC 1.1.1.44) 2 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1703016|sp|P53319.1|6PGD2_YEAST RecName: Full=6-phosphogluconate dehydrogenase, decarboxylating 2 [NCBI NR]
  • gi|1502359|emb|CAA67612.1| 6-phospho-gluconate dehydrogenase [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1323466|emb|CAA97285.1| GND2 [Saccharomyces cerevisiae] [NCBI NR]
  • 6-phosphogluconate dehydrogenase, decarboxylating 2 OS=Saccharomyces cerevisiae GN=GND2 PE=1 SV=1 [Swiss-Prot]
  • (P53319) 6-phosphogluconate dehydrogenase, decarboxylating 2 (EC 1.1.1.44) [Swiss-Prot]
  • GND2 Phosphogluconate dehydrogenase [mips]
  • 6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone [SGD]
  • GND2, Chr VII from 1004621-1006099 [yeast_orfs2]
  • Chr VII from 1004621-1006099 [yeastorf3.fasta]
  • Chr VII from 1004628-1006106 [yeastorf4.fasta]
  • GND2 SGDID:S0003488, Chr VII from 1004629-1006107, Verified ORF [yeastflysequest.fasta]
  • GND2 SGDID:S0003488, Chr VII from 1004630-1006108, Verified ORF [10112005cervSGD.fasta]
  • 6-phosphogluconate dehydrogenase, decarboxylating; converts 6-phosphogluconate + NADP to ribulose-5-phosphate + NADPH + CO2; 6-phosphogluconate dehydrogenase [Saccharomyces cerevisiae]gi|51013073|gb|AAT92830.1| YGR256W [Saccharomyces cerevisiae]gi|13234 [nrdb_11152004_Chlamydomonas]
  • GND2 SGDID:S000003488, Chr VII from 1004630-1006108, Verified ORF, "6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • YGR256W [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • 6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; Gnd2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • 6-phospho-gluconate dehydrogenase [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • 6-phosphogluconate dehydrogenase, decarboxylating 2 [nr-271106-contam.fasta]
  • GND2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • 6-phosphogluconate dehydrogenase, decarboxylating 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GND2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • GND2 SGDID:S000003488, Chr VII from 1004624-1006102, Genome Release 64-1-1, Verified ORF, "6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone" [yeast-030211-contam.fasta]
  • GND2 SGDID:S000003488, Chr VII from 1004624-1006102, Genome Release 64-2-1, Verified ORF, "6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YGR256W SGDID:S000003488, Chr VII from 1004624-1006102, Genome Release 64-1-1, Verified ORF, "6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 492 amino acids

    Gene Ontology:
    Cellular Component: cytosol [TASLink to PubMed article]
    Biological Process: pentose-phosphate shunt, oxidative branch [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: phosphogluconate dehydrogenase (decarboxylating) activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKAVGDLGL VGLAVMGQNL ILNAADHGFT VVAYNRTQSK VDRFLANEAK GKSIIGATSI  60
   61 EDLVAKLKKP RKIMLLIKAG APVDTLIKEL VPHLDKGDII IDGGNSHFPD TNRRYEELTK 120
  121 QGILFVGSGV SGGEDGARFG PSLMPGGSAE AWPHIKNIFQ SIAAKSNGEP CCEWVGPAGS 180
  181 GHYVKMVHNG IEYGDMQLIC EAYDIMKRIG RFTDKEISEV FDKWNTGVLD SFLIEITRDI 240
  241 LKFDDVDGKP LVEKIMDTAG QKGTGKWTAI NALDLGMPVT LIGEAVFARC LSAIKDERKR 300
  301 ASKLLAGPTV PKDAIHDREQ FVYDLEQALY ASKIISYAQG FMLIREAARS YGWKLNNPAI 360
  361 ALMWRGGCII RSVFLAEITK AYRDDPDLEN LLFNEFFASA VTKAQSGWRR TIALAATYGI 420
  421 PTPAFSTALA FYDGYRSERL PANLLQAQRD YFGAHTFRIL PECASAHLPV DKDIHINWTG 480
  481 HGGNISSSTY QA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ARO9 GND1 GND2
    View Details Ho Y, et al. (2002) AAT2 ACH1 ACO1 AFR1 AHP1 ARC1 ARF1 ATP3 CAR2 CDC33 CLU1 COF1 COR1 CPR1 CYR1 CYS4 EGD1 ERG13 ERG6 FPR1 FRS2 GND1 GND2 GRX1 GUS1 HEF3 HHF1, HHF2 LRO1 LSP1 MET6 NAN1 NTF2 OLA1 OYE2 PFK1 PIL1 PRM2 RNR2 RSN1 SAH1 SAP1 SCP160 SEC53 SEN15 SES1 SNU13 SOD1 TEF4 THS1 TIF1, TIF2 TMA19 TSA2 UBA1 VMA4 VMA5 WTM1 YNK1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DSN1 No Comments Hazbun TR, et al. (2003)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen ELM1 GND2 1 Unpublished Fields Lab Data
    View Screen NUP2 GND2 1 Unpublished Fields Lab Data
    View Screen PRP42 GND2 1 Unpublished Fields Lab Data
    View Screen UBC7 GND2 1 Unpublished Fields Lab Data
    View Screen GND2 ATG8 1 Unpublished Fields Lab Data
    View Screen RAS2 GND2 1 Unpublished Fields Lab Data
    View Screen GND2 IST2 1 Unpublished Fields Lab Data
    View Screen GND2 HSM3 1 Unpublished Fields Lab Data
    View Screen GND2 MIR1 1 Unpublished Fields Lab Data
    View Screen GND2 YJR142W 1 Unpublished Fields Lab Data
    View Screen GND2 APL2 1 Unpublished Fields Lab Data
    View Screen GND2 YKR032W 1 Unpublished Fields Lab Data
    View Screen GND2 OGG1 1 Unpublished Fields Lab Data
    View Screen GND2 YMR326C 1 Unpublished Fields Lab Data
    View Screen GND2 SPO1 1 Unpublished Fields Lab Data
    View Screen GND2 YNL320W 1 Unpublished Fields Lab Data
    View Screen RCY1 GND2 1 Unpublished Fields Lab Data
    View Screen YJR056C GND2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GND2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..182] PSI-BLAST 1936.0 6-phosphogluconate dehydrogenase (6PGD); 6-phosphogluconate dehydrogenase
    2 View Details [183..492] PSI-BLAST 1936.0 6-phosphogluconate dehydrogenase (6PGD); 6-phosphogluconate dehydrogenase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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