Protein Overview: SIP2

General Information:
Name(s) found:	SIP2 / YGL208W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6321230\|ref\|NP_011307.1\| One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma [NCBI NR] gi\|468428\|gb\|AAC37420.1\| Sip2p [Saccharomyces cerevisiae] [NCBI NR] gi\|464800\|sp\|P34164.3\|SIP2_YEAST RecName: Full=SNF1 protein kinase subunit beta-2; AltName: Full=SNF1-interacting protein 2; AltName: Full=Protein SPM2 [NCBI NR] gi\|287915\|emb\|CAA78503.1\| spm2+ [Saccharomyces cerevisiae] [NCBI NR] gi\|1322846\|emb\|CAA96922.1\| SIP2 [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S51792 SIP2 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] SNF1 protein kinase subunit beta-2 OS=Saccharomyces cerevisiae GN=SIP2 PE=1 SV=3 [Swiss-Prot] SIP2 beta-subunit of the Snf1 kinase complex, allows cytoplasma localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source [mips] One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane [SGD] SIP2, Chr VII from 97340-98587 [yeast_orfs2] Chr VII from 97340-98587 [yeastorf3.fasta] (P34164) SIP2 protein (SPM2 protein) [4932.FASTACCERV.txt] SIP2 SGDID:S0003176, Chr VII from 97340-98587, Verified ORF [yeastflysequest.fasta] SIP2 SGDID:S0003176, Chr VII from 97342-98589, Verified ORF [10112005cervSGD.fasta] Member of a family of proteins, including Sip1p and Gal83p, that interact with Snf1p and Snf4p and are involved in the response to glucose starvation; component of Snf1 protein complex involved in response to glucose starvation [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas] SIP2 SGDID:S000003176, Chr VII from 97342-98589, Verified ORF, "One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein local [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] spm2+ [Saccharomyces cerevisiae] [nr-271106-contam.fasta] One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane; Sip2p [Saccharomy [nr-271106-contam.fasta] Protein SIP2 (Protein SPM2) [nr-271106-contam.fasta] Sip2p [nr-271106-contam.fasta] SIP2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] SIP2 SGDID:S000003176, Chr VII from 97342-98589, Verified ORF, "One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane" [yeast-bovrabprots.fasta] [chemostatdb.fasta] SNF1 protein kinase subunit beta-2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SIP2 PE=1 SV=3 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] SIP2 SGDID:S000003176, Chr VII from 97338-98585, Genome Release 64-1-1, Verified ORF, "One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane" [yeast-030211-contam.fasta] SIP2 SGDID:S000003176, Chr VII from 97338-98585, Genome Release 64-2-1, Verified ORF, "One of three beta subunits of the Snf1 kinase complex; involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane; SIP2 has a paralog, GAL83, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YGL208W SGDID:S000003176, Chr VII from 97338-98585, Genome Release 64-1-1, Verified ORF, "One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	415 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA] plasma membrane [IDA] AMP-activated protein kinase complex [IDA][IPI ]
Biological Process:	signal transduction [IGI] regulation of protein complex assembly [IGI] invasive growth in response to glucose limitation [IGI] protein amino acid phosphorylation [IGI] replicative cell aging [IGI][IMP ] cellular response to glucose starvation [IMP]
Molecular Function:	AMP-activated protein kinase activity [IGI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGTTTSHPAQ KKQTTKKCRA PIMSDVREKP SNAQGCEPQE MDAVSKKVTE LSLNKCSDSQ  60
   61 DAGQPSREGS ITKKKSTLLL RDEDEPTMPK LSVMETAVDT DSGSSSTSDD EEGDIIAQTT 120
  121 EPKQDASPDD DRSGHSSPRE EGQQQIRAKE ASGGPSEIKS SLMVPVEIRW QQGGSKVYVT 180
  181 GSFTKWRKMI GLIPDSDNNG SFHVKLRLLP GTHRFRFIVD NELRVSDFLP TATDQMGNFV 240
  241 NYIEVRQPEK NPTNEKIRSK EADSMRPPTS DRSSIALQIG KDPDDFGDGY TRFHEDLSPR 300
  301 PPLEYTTDIP AVFTDPSVME RYYYTLDRQQ SNTDTSWLTP PQLPPQLENV ILNKYYATQD 360
  361 QFNENNSGAL PIPNHVVLNH LVTSSIKHNT LCVASIVRYK QKYVTQILYT PIESS

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		GAL83 SIP2 SNF1 SNF4
View Details	(MIPS) Mewes HW, et al. (2004)		GAL83 SIP1 SIP2 SIP4 SNF1 SNF4
View Details	Krogan NJ, et al. (2006)		GAL83 RAD30 SAK1 SIP1 SIP2 SNF1 SNF4
View Details	Gavin AC, et al. (2002)		BMH1 CKA1 CKB1 GAL83 REG1 SAK1 SIP1 SIP2 SNF1 SNF4
View Details	Ho Y, et al. (2002)		ARC35 GAL83 IDH2 SEC53 SEC7 SIP2 SNF1 SNF4 TCP1 YMR086W
View Details	Qiu et al. (2008)		GAL83 SIP1 SIP2 SIP4 SNF1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	FUN19	SIP2	2	Unpublished Fields Lab Data
View Screen	MPC54	SIP2	2	Unpublished Fields Lab Data
View Screen	IMD1	SIP2	2	Unpublished Fields Lab Data
View Screen	YCK1	SIP2	2	Unpublished Fields Lab Data
View Screen	KAP104	SIP2	2	Unpublished Fields Lab Data
View Screen	PRP40	SIP2	2	Unpublished Fields Lab Data
View Screen	SNF1	SIP2	2	Uetz P, et al. (2000)
View Screen	YPI1	SIP2	2	Hazbun TR, et al. (2003)
View Screen	SNF4	SIP2	2	Unpublished Fields Lab Data
View Screen	IRE1	SIP2	1	Unpublished Fields Lab Data
View Screen	MPC54	SIP2	1	Unpublished Fields Lab Data
View Screen	YHR122W	SIP2	1	Hazbun TR, et al. (2003)
View Screen	YOR203W	SIP2	1	Unpublished Fields Lab Data
View Screen	SEC17	SIP2	1	Unpublished Fields Lab Data
View Screen	SDP1	SIP2	1	Unpublished Fields Lab Data
View Screen	KAP104	SIP2	1	Unpublished Fields Lab Data
View Screen	MET18	SIP2	1	Unpublished Fields Lab Data
View Screen	IML1	SIP2	1	Unpublished Fields Lab Data
View Screen	CIT2	SIP2	1	Unpublished Fields Lab Data
View Screen	YDL121C	SIP2	1	Unpublished Fields Lab Data
View Screen	BUD2	SIP2	1	Unpublished Fields Lab Data
View Screen	PDS1	SIP2	1	Unpublished Fields Lab Data
View Screen	YJU2	SIP2	1	Unpublished Fields Lab Data
View Screen	RPT1	SIP2	1	Unpublished Fields Lab Data
View Screen	UBC6	SIP2	1	Unpublished Fields Lab Data
View Screen	ORC3	SIP2	1	Unpublished Fields Lab Data
View Screen	ADH2	SIP2	1	Unpublished Fields Lab Data
View Screen	SGF73	SIP2	1	Unpublished Fields Lab Data
View Screen	RAS2	SIP2	1	Unpublished Fields Lab Data
View Screen	PFS2	SIP2	1	Unpublished Fields Lab Data
View Screen	RSR1	SIP2	1	Unpublished Fields Lab Data
View Screen	PPG1	SIP2	1	Unpublished Fields Lab Data
View Screen	PUT2	SIP2	1	Unpublished Fields Lab Data
View Screen	HRT1	SIP2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..97]	deduced	N/A	No confident structure predictions are available.
2	View Details	[98..415]	MSA	11.051951	View MSA. No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
AMP-activated protein kinase activity	4.78975226545815	bayes_pls_golite062009
binding	2.65544526722793	bayes_pls_golite062009
voltage-gated potassium channel activity	2.18099602369564	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.66390525860632	bayes_pls_golite062009
kinase activity	1.64560031716993	bayes_pls_golite062009
cation channel activity	1.61654093209843	bayes_pls_golite062009
ligand-gated channel activity	1.56948414427108	bayes_pls_golite062009
ligand-gated ion channel activity	1.56948414427108	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.53194692728729	bayes_pls_golite062009
protein binding	1.50286160643298	bayes_pls_golite062009
gated channel activity	1.48812502999143	bayes_pls_golite062009
cation transmembrane transporter activity	1.46948685366075	bayes_pls_golite062009
protein kinase activity	1.44964326848891	bayes_pls_golite062009
transferase activity	1.26709925711174	bayes_pls_golite062009
signal transducer activity	1.12993648323166	bayes_pls_golite062009
molecular transducer activity	1.12993648323166	bayes_pls_golite062009
ion channel activity	1.10689326077049	bayes_pls_golite062009
protein serine/threonine kinase activity	0.726369450752205	bayes_pls_golite062009
cytoskeletal protein binding	0.60798225319459	bayes_pls_golite062009
actin binding	0.54002000529721	bayes_pls_golite062009
enzyme binding	0.37496592438035	bayes_pls_golite062009
inward rectifier potassium channel activity	0.252254893587557	bayes_pls_golite062009
potassium channel activity	0.0778382534131277	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2