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Protein Overview: SIP1

General Information:
Name(s) found: SIP1 / YDR422C [SGD]
Description(s) found:
Found 20 descriptions.
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  • Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 863 amino acids

    Gene Ontology:
    Cellular Component: vacuole [IDALink to PubMed article]
    AMP-activated protein kinase complex [IDALink to PubMed article][IPILink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: signal transduction [IGILink to PubMed article]
    regulation of protein complex assembly [IGILink to PubMed article]
    protein amino acid phosphorylation [IGILink to PubMed article]
    Molecular Function: AMP-activated protein kinase activity [IGILink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDISDTSGY LHKQGVLPSV SFICTSFFAC GLTSWKVELS YYIVVAAAMG NSPSTQDPSH  60
   61 STKKEHGHHF HDAFNKDRQG SITSQLFNNR KSTHKRRASH TSEHNGAIPP RMQLLASHDP 120
  121 STDCDGRMSS DTTIDKGPSH LFKKDYSLSS AADVNDTTLA NLTLSDDHDV GAPEEQVKSP 180
  181 SFLSPGPSMA TVKRTKSDLD DLSTLNYTMV DETTENERND KPHHERHRSS IIALKKNLLE 240
  241 SSATASPSPT RSSSVHSASL PALTKTDSID IPVRQPYSKK PSIHAYQYQY LNNDETFSEN 300
  301 SQMDKEGNSD SVDAEAGVLQ SEDMVLNQSL LQNALKKDMQ RLSRVNSSNS MYTAERISHA 360
  361 NNNGNIENNT RNKGNAGGSN DDFTAPISAT AKMMMKLYGD KTLMERDLNK HHNKTKKAQN 420
  421 KKIRSVSNSR RSSFASLHSL QSRKSILTNG LNLQPLHPLH PIINDNESQY SAPQHREISH 480
  481 HSNSMSSMSS ISSTNSTENT LVVLKWKDDG TVAATTEVFI VSTDIASALK EQRELTLDEN 540
  541 ASLDSEKQLN PRIRMVYDDV HKEWFVPDLF LPAGIYRLQF SINGILTHSN FLPTATDSEG 600
  601 NFVNWFEVLP GYHTIEPFRN EADIDSQVEP TLDEELPKRP ELKRFPSSSR KSSYYSAKGV 660
  661 ERPSTPFSDY RGLSRSSSIN MRDSFVRLKA SSLDLMAEVK PERLVYSNEI PNLFNIGDGS 720
  721 TISVKGDSDD VHPQEPPSFT HRVVDCNQDD LFATLQQGGN IDAETAEAVF LSRYPVPDLP 780
  781 IYLNSSYLNR ILNQSNQNSE SHERDEGAIN HIIPHVNLNH LLTSSIRDEI ISVACTTRYE 840
  841 GKFITQVVYA PCYYKTQKSQ ISN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) GAL83 SIP1 SIP2 SIP4 SNF1 SNF4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIF2 No Comments Cheeseman IM, et al. (2002)
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run CLB2 No Comments McCusker D, et al (2007)
    View Run CLB2 No Comments McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen UBC12 SIP1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..483] deduced N/A No confident structure predictions are available.
    2 View Details [484..677] MSA 1.007967 View MSA. No confident structure predictions are available.
    3 View Details [678..863] MSA 7.016987 View MSA. No confident structure predictions are available.
    4 View Details [551..863] PSI-BLAST 85.0 No description for 2qlvB was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • AMP-activated protein kinase activity
    		•  4.78975226545815 bayes_pls_golite062009
  • binding
    		•  2.22611204798233 bayes_pls_golite062009
  • protein binding
    		•  1.50286160643298 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.21252601175223 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.20869454170074 bayes_pls_golite062009
  • kinase activity
    		•  1.1759320472197 bayes_pls_golite062009
  • protein kinase activity
    		•  1.16294708854294 bayes_pls_golite062009
  • cation channel activity
    		•  1.10928620793874 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  1.08920948133636 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  1.08920948133636 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.03266511838083 bayes_pls_golite062009
  • gated channel activity
    		•  0.9831902560942 bayes_pls_golite062009
  • ion channel activity
    		•  0.88499192552319 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.726369450752205 bayes_pls_golite062009
  • transferase activity
    		•  0.563590737734601 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.24498703916422 bayes_pls_golite062009
  • actin binding
    		•  0.15943777627145 bayes_pls_golite062009
  • hydrolase activity
    		•  0.0943317805489587 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.77

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle