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Protein Overview: RGD2

General Information:
Name(s) found: RGD2 / YFL047W [SGD]
Description(s) found:
Found 22 descriptions.
SHOW ALL
  • GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 714 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    cellular bud neck [IDALink to PubMed article]
    Biological Process: small GTPase mediated signal transduction [ICLink to PubMed article][IPILink to PubMed article]
    Molecular Function: Rho GTPase activator activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSFCDYFWS EDLVSGLDVL FDRLYHGCEQ CDLFIQLFAS RMQFEVSHGR QLFGIEAGMD  60
   61 NLKAVQEDED EGVTVSRALR GILQEMSQEG THHLTIASNI ESLVLQPFSK WCIEHRERIQ 120
  121 YSEKTLLTNV NNFRKSKKYV GKLEKEYFNK CRQLEEFKRT HFNEDELANA MKSLKIQNKY 180
  181 EEDVAREKDH RFFNRIAGID FDYKTMKETL QLLLTKLPKT DYKLPLISYS LSNTNNGGEI 240
  241 TKFLLDHMSL KDIDQAETFG QDLLNLGFLK YCNGVGNTFV NSKKFQYQWK NTAYMFANVP 300
  301 MPGSEEPTTG ESLISRFNNW DGSSAKEIIQ SKIGNDQGAA KIQAPHISDN ERTLFRMMDA 360
  361 LAASDKKYYQ ECFKMDALRC SVEELLIDHL SFMEKCESDR LNAIKKATLD FCSTLGNKIS 420
  421 SLRLCIDKML TLENDIDPTA DLLQLLVKYK TGSFKPQAIV YNNYYNPGSF QNFGVDLETR 480
  481 CRLDKKVVPL IISSIFSYMD KIYPDLPNDK VRTSIWTDSV KLSLTHQLRN LLNKQQFHNE 540
  541 GEIFDILSTS KLEPSTIASV VKIYLLELPD PLIPNDVSDI LRVLYLDYPP LVETALQNST 600
  601 SSPENQQDDD NEEGFDTKRI RGLYTTLSSL SKPHIATLDA ITTHFYRLIK ILKMGENGNE 660
  661 VADEFTVSIS QEFANCIIQS KITDDNEIGF KIFYDLLTHK KQIFHELKRQ NSKN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) LRG1 RGD2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RGD2 GIP3 2 Unpublished Fields Lab Data
    View Screen RGD2 UME1 2 Unpublished Fields Lab Data
    View Screen RGD2 VPS45 2 Unpublished Fields Lab Data
    View Screen RGD2 NCE102 2 Unpublished Fields Lab Data
    View Screen RGD2 YKU80 2 Unpublished Fields Lab Data
    View Screen RGD2 YPR197C 2 Unpublished Fields Lab Data
    View Screen RGD2 PET494 2 Unpublished Fields Lab Data
    View Screen RGD2 AAR2 2 Unpublished Fields Lab Data
    View Screen RGD2 YCL073C 2 Unpublished Fields Lab Data
    View Screen RGD2 RFC2 2 Unpublished Fields Lab Data
    View Screen RGD2 YDL218W 2 Unpublished Fields Lab Data
    View Screen RGD2 RPL4B 2 Unpublished Fields Lab Data
    View Screen RGD2 KAR9 2 Unpublished Fields Lab Data
    View Screen RGD2 KEI1 2 Unpublished Fields Lab Data
    View Screen RGD2 STE14 2 Unpublished Fields Lab Data
    View Screen RGD2 GCN4 2 Unpublished Fields Lab Data
    View Screen RGD2 EMC2 2 Unpublished Fields Lab Data
    View Screen RGD2 RNP1 2 Unpublished Fields Lab Data
    View Screen RGD2 APL2 2 Unpublished Fields Lab Data
    View Screen RGD2 CBS2 2 Unpublished Fields Lab Data
    View Screen RGD2 SEN1 2 Unpublished Fields Lab Data
    View Screen RGD2 PET494 1 Unpublished Fields Lab Data
    View Screen RGD2 PPZ2 1 Unpublished Fields Lab Data
    View Screen RGD2 NOP56 1 Unpublished Fields Lab Data
    View Screen RGD2 YFR056C 1 Unpublished Fields Lab Data
    View Screen RGD2 VPS38 1 Unpublished Fields Lab Data
    View Screen RGD2 SPO20 1 Unpublished Fields Lab Data
    View Screen RGD2 ASN2 1 Unpublished Fields Lab Data
    View Screen RGD2 YHR003C 1 Unpublished Fields Lab Data
    View Screen RGD2 RXT2 1 Unpublished Fields Lab Data
    View Screen RGD2 QNS1 1 Unpublished Fields Lab Data
    View Screen RGD2 RAT1 1 Unpublished Fields Lab Data
    View Screen RGD2 SHG1 1 Unpublished Fields Lab Data
    View Screen RGD2 AIM23 1 Unpublished Fields Lab Data
    View Screen RGD2 DCS2 1 Unpublished Fields Lab Data
    View Screen RGD2 RRT12 1 Unpublished Fields Lab Data
    View Screen RGD2 RDS2 1 Unpublished Fields Lab Data
    View Screen RGD2 YCR099C 1 Unpublished Fields Lab Data
    View Screen RGD2 SWD2 1 Unpublished Fields Lab Data
    View Screen RGD2 MKK2 1 Unpublished Fields Lab Data
    View Screen RGD2 THI3 1 Unpublished Fields Lab Data
    View Screen RGD2 RMA1 1 Unpublished Fields Lab Data
    View Screen RGD2 RPP1A 1 Unpublished Fields Lab Data
    View Screen RGD2 APL2 1 Unpublished Fields Lab Data
    View Screen RGD2 ARP7 1 Unpublished Fields Lab Data
    View Screen RGD2 HBT1 1 Unpublished Fields Lab Data
    View Screen RGD2 TRZ1 1 Unpublished Fields Lab Data
    View Screen RGD2 YPR089W 1 Unpublished Fields Lab Data
    View Screen RGD2 STE5 1 Unpublished Fields Lab Data
    View Screen RGD2 YLL007C 1 Unpublished Fields Lab Data
    View Screen RGD2 MRI1 1 Unpublished Fields Lab Data
    View Screen RGD2 YDR131C 1 Unpublished Fields Lab Data
    View Screen RGD2 DPM1 1 Unpublished Fields Lab Data
    View Screen RGD2 YLR046C 1 Unpublished Fields Lab Data
    View Screen RAD6 RGD2 1 Unpublished Fields Lab Data
    View Screen RGD2 SAC7 1 Unpublished Fields Lab Data
    View Screen RGD2 MMR1 1 Unpublished Fields Lab Data
    View Screen CTF13 RGD2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RGD2 Huh WK, et al. (2003)
    View Data RGD2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..225] ORFEUS 9.07 Apolipoprotein A-I
    2 View Details [226..299] Pfam 12.180456 Domain found in Dishevelled, Egl-10, and Pleckstrin No confident structure predictions are available.
    3 View Details [300..366] deduced N/A No confident structure predictions are available.
    4 View Details [367..569] PSI-BLAST 38.0 p50 RhoGAP domain
    5 View Details [570..714] PSI-BLAST 38.0 p50 RhoGAP domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  3.124619761789 bayes_pls_golite062009
  • binding
    		•  2.22529267810903 bayes_pls_golite062009
  • protein binding
    		•  1.87308005875135 bayes_pls_golite062009
  • identical protein binding
    		•  0.909409198394921 bayes_pls_golite062009
  • enzyme binding
    		•  0.58709209959999 bayes_pls_golite062009
  • GTPase binding
    		•  0.50066793947946 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.459881864914566 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.456472132383968 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.180886944097381 bayes_pls_golite062009
  • small GTPase binding
    		•  0.0531578648468707 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • GTPase regulator activity
    		•  5.23789256375467 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  5.21562004568462 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  4.91645234075732 bayes_pls_golite062009
  • GTPase activator activity
    		•  4.81440293338491 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  4.76400460221691 bayes_pls_golite062009
  • Rho GTPase activator activity
    		•  4.58620967349979 bayes_pls_golite062009
  • enzyme regulator activity
    		•  4.5322075775333 bayes_pls_golite062009
  • Rac GTPase activator activity
    		•  4.48279904625182 bayes_pls_golite062009
  • enzyme activator activity
    		•  4.29367232260052 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.68681762274025 bayes_pls_golite062009
  • actin binding
    		•  3.68337819140185 bayes_pls_golite062009
  • actin filament binding
    		•  2.37781909937968 bayes_pls_golite062009
  • microfilament motor activity
    		•  2.15518436158221 bayes_pls_golite062009
  • binding
    		•  1.62780792681766 bayes_pls_golite062009
  • protein binding
    		•  1.21496582666968 bayes_pls_golite062009
  • Rho guanyl-nucleotide exchange factor activity
    		•  0.967362611034944 bayes_pls_golite062009
  • enzyme binding
    		•  0.56024350956935 bayes_pls_golite062009
  • GTPase binding
    		•  0.54882559587114 bayes_pls_golite062009
  • small GTPase binding
    		•  0.36738560339155 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle