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Protein Overview: EMC2

General Information:
Name(s) found: EMC2 / YJR088C [SGD]
Description(s) found:
Found 32 descriptions.
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  • Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 292 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKDLVREKL LTIMNTKAYT QFNPEQLLQL ENEMKIYMKS GDSALTEGNY FFLMEMLFYV  60
   61 LVYRNQDVDA QVVYNTLRDR LGENSYKMVI MKATLLQING NDKGAIEYLE NLLNDDLEYE 120
  121 TDFVTYVSIA KKLIAIKTTS KNLSQESVLK EVVALTDKFP LDAELWWYAS EIYFEMGQFE 180
  181 KACYCLEQVL CITPFNYACF GRLSETLYYE ALRSKKQTKT ELLEKALKNA LRSVELSELY 240
  241 LKGWALVNII SRELGRNKQN DLIKLSASKL KEISAKSNNK DKITAELILN KI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RGD2 EMC2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data EMC2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..100] PSI-BLAST 29.09691 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    2 View Details [101..177] PSI-BLAST 29.09691 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    3 View Details [178..292] PSI-BLAST 29.09691 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  0.911909606569877 bayes_pls_golite062009
  • protein binding
    		•  0.420010637453541 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle