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Protein Overview: LRG1

General Information:
Name(s) found: LRG1 / YDL240W [SGD]
Description(s) found:
Found 18 descriptions.
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  • Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1017 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    cellular bud neck [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: fungal-type cell wall biogenesis [IGILink to PubMed article]
    small GTPase mediated signal transduction [ICLink to PubMed article][IPILink to PubMed article]
    Molecular Function: Rho GTPase activator activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIQNSAGYRS LNTASPMTVQ VKNQKKICAR CNKLVIPDSQ RTKTTLKALG KYYHESCFTC  60
   61 QDCQKPLKPK YFPYQVDKTS ESILLCQYDY FRRHNLLCHV CDTPLRGLYY TAFGYRYDEE 120
  121 HFSCTICATP CGVKKCFMYG NQLYCKYHFL KYFSKRCKGC EFPISDQYIE FPKGEEIHCW 180
  181 HPECYGIHKY WHVNLAAETV GLQYLPKLEY NPNSGDKDIN PTAYELDKQM QAFNFILSKT 240
  241 WSVLYRFEEE AASCISDMFQ YLTSNDQLKG IESTGLLVLK IDCLFRGLDT LNLSTNKSMP 300
  301 VNSDQECIEN NAMAASKYSK FPKNLSTKIM IYLQLLRKLG TENKNETITI SSFMSVITGL 360
  361 AHFLKLLTRF GLYTALENNK LTHSVNPLLR FLREVEKNEL FENNPFQYIK TPVNATDSCA 420
  421 GCNKYIQEEC IQFYEHRWHI ACFTCSSCHK NINPRSLTDP TFNKEKKKIL CSHCSIDDPA 480
  481 SVPGFKFVTK LAQLIFLLKI ALVKSRTVML KSKASNKVGR NSLQSTMLKE HTYIRTLNDI 540
  541 KRLRSRRESV RVTHNKQQAR KSVILETAET DLNDPTKQGD SKNLVIQTDD PSSSQQVSTR 600
  601 ENVFSNTKTL TLDDISRIVA AEQARELRPN AFAHFKKLKE TDDETSNVVP KKSGVYYSEL 660
  661 STMELSMIRA ISLSLLAGKQ LISKTDPNYT SLVSMVFSNE KQVTGSFWNR MKIMMSMEPK 720
  721 KPITKTVFGA PLDVLCEKWG VDSDLGVGPV KIRIPIIIDE LISSLRQMDM SVEGIFRKNG 780
  781 NIRRLRELTA NIDSNPTEAP DFSKENAIQL SALLKKFIRE LPQPILSTDL YELWIKAAKI 840
  841 DLEDEKQRVI LLIYSLLPTY NRNLLEALLS FLHWTSSFSY IENEMGSKMD IHNLSTVITP 900
  901 NILYLRHKEI SNDNVPDEPE SGLVDSFAQN KGENYFLAIE IVDYLITHNE EMAMVPKFLM 960
  961 NLLKDVQLQK LDNYESINHF ISTVMQSKTI DYSECDIKTP VTVKDSTTTV IQGEINK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) BUD5 CDC24 LRG1 RGD1 RGD2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data LRG1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..93] PSI-BLAST 10.30103 Cysteine-rich (intestinal) protein, CRP, CRIP
    2 View Details [94..210] PSI-BLAST 10.30103 Cysteine-rich (intestinal) protein, CRP, CRIP
    3 View Details [211..298] MSA 4.127997 View MSA. Confident ab initio structure predictions are available.
    4 View Details [299..410] deduced N/A Confident ab initio structure predictions are available.
    5 View Details [411..482] Pfam 15.431798 LIM domain No confident structure predictions are available.
    6 View Details [483..653] MSA 1.106979 View MSA. No confident structure predictions are available.
    7 View Details [654..821] PSI-BLAST 207.927757 p50 RhoGAP domain
    8 View Details [822..963] PSI-BLAST 207.927757 p50 RhoGAP domain
    9 View Details [964..1017] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.96409924710655 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.22839475692516 bayes_pls_golite062009
  • DNA binding
    		•  1.96428761552366 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.86972157198727 bayes_pls_golite062009
  • signal transducer activity
    		•  1.86972157198727 bayes_pls_golite062009
  • receptor activity
    		•  1.84800188265901 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.73351698570585 bayes_pls_golite062009
  • transcription factor activity
    		•  1.41077905480556 bayes_pls_golite062009
  • protein binding
    		•  1.39455913713025 bayes_pls_golite062009
  • transporter activity
    		•  0.883869495141753 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.69816175939074 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.6267176811988 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  0.55799224325565 bayes_pls_golite062009
  • transcription activator activity
    		•  0.53223427184258 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.480921069521595 bayes_pls_golite062009
  • transcription factor binding
    		•  0.43597775400036 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.30102391671156 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.248246733554633 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.14923328147546 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.110294001412626 bayes_pls_golite062009
  • actin binding
    		•  0.0158809112602751 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • Rho GTPase activator activity
    		•  4.58620967349979 bayes_pls_golite062009
  • Rac GTPase activator activity
    		•  4.48279904625182 bayes_pls_golite062009
  • binding
    		•  2.79128751898373 bayes_pls_golite062009
  • GTPase regulator activity
    		•  2.70614727793157 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  2.68579854252375 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  2.06038764955701 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.9750017471254 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.95738547986197 bayes_pls_golite062009
  • protein binding
    		•  1.29100556128076 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.27693544428588 bayes_pls_golite062009
  • signal transducer activity
    		•  1.25507073225414 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.25507073225414 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.2233434243135 bayes_pls_golite062009
  • myosin heavy chain kinase activity
    		•  1.15190288326422 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  1.09070479183477 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.08577758274384 bayes_pls_golite062009
  • actin binding
    		•  1.02058870188398 bayes_pls_golite062009
  • Rho guanyl-nucleotide exchange factor activity
    		•  0.967362611034944 bayes_pls_golite062009
  • Ras guanyl-nucleotide exchange factor activity
    		•  0.958295643211986 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.717730683557543 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.480348726111787 bayes_pls_golite062009
  • receptor activity
    		•  0.434186339265983 bayes_pls_golite062009
  • DNA binding
    		•  0.418154636457321 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.298334474872045 bayes_pls_golite062009
  • microfilament motor activity
    		•  0.0044514849726196 bayes_pls_golite062009
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle