| Protein: | LRG1 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 1017 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LRG1.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..1017] | [1..1017] |
|
|
0.0 | [9..968] | [97..1053] |
|
|
3.0E-95 | [512..1011] | [136..602] |
|
|
4.0E-87 | [514..1005] | [139..593] |
|
|
9.0E-86 | [522..1009] | [1423..1922] |
|
Region A: Residues: [1-93] |
1 11 21 31 41 51
| | | | | |
1 MIQNSAGYRS LNTASPMTVQ VKNQKKICAR CNKLVIPDSQ RTKTTLKALG KYYHESCFTC 60
61 QDCQKPLKPK YFPYQVDKTS ESILLCQYDY FRR
|
| Detection Method: |  |
| Confidence: | 10.30103 |
| Match: | 1b8tA_ |
| Description: | Cysteine-rich (intestinal) protein, CRP, CRIP |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| binding | 2.96409924710655 | bayes_pls_golite062009 |
| transcription regulator activity | 2.22839475692516 | bayes_pls_golite062009 |
| DNA binding | 1.96428761552366 | bayes_pls_golite062009 |
| molecular transducer activity | 1.86972157198727 | bayes_pls_golite062009 |
| signal transducer activity | 1.86972157198727 | bayes_pls_golite062009 |
| receptor activity | 1.84800188265901 | bayes_pls_golite062009 |
| nucleic acid binding | 1.73351698570585 | bayes_pls_golite062009 |
| transcription factor activity | 1.41077905480556 | bayes_pls_golite062009 |
| protein binding | 1.39455913713025 | bayes_pls_golite062009 |
| transporter activity | 0.883869495141753 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.69816175939074 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 0.6267176811988 | bayes_pls_golite062009 |
| ligand-dependent nuclear receptor activity | 0.55799224325565 | bayes_pls_golite062009 |
| transcription activator activity | 0.53223427184258 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.480921069521595 | bayes_pls_golite062009 |
| transcription factor binding | 0.43597775400036 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 0.30102391671156 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 0.248246733554633 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 0.14923328147546 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 0.110294001412626 | bayes_pls_golite062009 |
| actin binding | 0.0158809112602751 | bayes_pls_golite062009 |
|
Region A: Residues: [94-210] |
1 11 21 31 41 51
| | | | | |
1 HNLLCHVCDT PLRGLYYTAF GYRYDEEHFS CTICATPCGV KKCFMYGNQL YCKYHFLKYF 60
61 SKRCKGCEFP ISDQYIEFPK GEEIHCWHPE CYGIHKYWHV NLAAETVGLQ YLPKLEY
|
| Detection Method: | |
| Confidence: | 10.30103 |
| Match: | 1b8tA_ |
| Description: | Cysteine-rich (intestinal) protein, CRP, CRIP |
| Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [211-298] |
1 11 21 31 41 51
| | | | | |
1 NPNSGDKDIN PTAYELDKQM QAFNFILSKT WSVLYRFEEE AASCISDMFQ YLTSNDQLKG 60
61 IESTGLLVLK IDCLFRGLDT LNLSTNKS
|
| Detection Method: | |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.960 | 0.021 | Rho GTPase activator activity | a.7.3 | Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain |
|
Region A: Residues: [299-410] |
1 11 21 31 41 51
| | | | | |
1 MPVNSDQECI ENNAMAASKY SKFPKNLSTK IMIYLQLLRK LGTENKNETI TISSFMSVIT 60
61 GLAHFLKLLT RFGLYTALEN NKLTHSVNPL LRFLREVEKN ELFENNPFQY IK
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.951 | 0.025 | Rho GTPase activator activity | a.47.2 | t-snare proteins |
|
Region A: Residues: [411-482] |
1 11 21 31 41 51
| | | | | |
1 TPVNATDSCA GCNKYIQEEC IQFYEHRWHI ACFTCSSCHK NINPRSLTDP TFNKEKKKIL 60
61 CSHCSIDDPA SV
|
| Detection Method: | |
| Confidence: | 15.431798 |
| Match: | PF00412 |
| Description: | LIM domain |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [483-653] |
1 11 21 31 41 51
| | | | | |
1 PGFKFVTKLA QLIFLLKIAL VKSRTVMLKS KASNKVGRNS LQSTMLKEHT YIRTLNDIKR 60
61 LRSRRESVRV THNKQQARKS VILETAETDL NDPTKQGDSK NLVIQTDDPS SSQQVSTREN 120
121 VFSNTKTLTL DDISRIVAAE QARELRPNAF AHFKKLKETD DETSNVVPKK S
|
| Detection Method: | |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
| Term | Confidence | Notes |
| Rho GTPase activator activity | 4.58620967349979 | bayes_pls_golite062009 |
| Rac GTPase activator activity | 4.48279904625182 | bayes_pls_golite062009 |
| binding | 2.79128751898373 | bayes_pls_golite062009 |
| GTPase regulator activity | 2.70614727793157 | bayes_pls_golite062009 |
| nucleoside-triphosphatase regulator activity | 2.68579854252375 | bayes_pls_golite062009 |
| guanyl-nucleotide exchange factor activity | 2.06038764955701 | bayes_pls_golite062009 |
| enzyme regulator activity | 1.9750017471254 | bayes_pls_golite062009 |
| small GTPase regulator activity | 1.95738547986197 | bayes_pls_golite062009 |
| protein binding | 1.29100556128076 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 1.27693544428588 | bayes_pls_golite062009 |
| signal transducer activity | 1.25507073225414 | bayes_pls_golite062009 |
| molecular transducer activity | 1.25507073225414 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 1.2233434243135 | bayes_pls_golite062009 |
| myosin heavy chain kinase activity | 1.15190288326422 | bayes_pls_golite062009 |
| Ras GTPase activator activity | 1.09070479183477 | bayes_pls_golite062009 |
| transcription regulator activity | 1.08577758274384 | bayes_pls_golite062009 |
| actin binding | 1.02058870188398 | bayes_pls_golite062009 |
| Rho guanyl-nucleotide exchange factor activity | 0.967362611034944 | bayes_pls_golite062009 |
| Ras guanyl-nucleotide exchange factor activity | 0.958295643211986 | bayes_pls_golite062009 |
| GTPase activator activity | 0.717730683557543 | bayes_pls_golite062009 |
| nucleic acid binding | 0.480348726111787 | bayes_pls_golite062009 |
| receptor activity | 0.434186339265983 | bayes_pls_golite062009 |
| DNA binding | 0.418154636457321 | bayes_pls_golite062009 |
| enzyme activator activity | 0.298334474872045 | bayes_pls_golite062009 |
| microfilament motor activity | 0.0044514849726196 | bayes_pls_golite062009 |
|
Region A: Residues: [654-821] |
1 11 21 31 41 51
| | | | | |
1 GVYYSELSTM ELSMIRAISL SLLAGKQLIS KTDPNYTSLV SMVFSNEKQV TGSFWNRMKI 60
61 MMSMEPKKPI TKTVFGAPLD VLCEKWGVDS DLGVGPVKIR IPIIIDELIS SLRQMDMSVE 120
121 GIFRKNGNIR RLRELTANID SNPTEAPDFS KENAIQLSAL LKKFIREL
|
| Detection Method: | |
| Confidence: | 207.927757 |
| Match: | 1am4A_ |
| Description: | p50 RhoGAP domain |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [822-963] |
1 11 21 31 41 51
| | | | | |
1 PQPILSTDLY ELWIKAAKID LEDEKQRVIL LIYSLLPTYN RNLLEALLSF LHWTSSFSYI 60
61 ENEMGSKMDI HNLSTVITPN ILYLRHKEIS NDNVPDEPES GLVDSFAQNK GENYFLAIEI 120
121 VDYLITHNEE MAMVPKFLMN LL
|
| Detection Method: | |
| Confidence: | 207.927757 |
| Match: | 1am4A_ |
| Description: | p50 RhoGAP domain |
| Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [964-1017] |
1 11 21 31 41 51
| | | | | |
1 KDVQLQKLDN YESINHFIST VMQSKTIDYS ECDIKTPVTV KDSTTTVIQG EINK
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
