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Protein Overview: SAC7

General Information:
Name(s) found: SAC7 / YDR389W [SGD]
Description(s) found:
Found 27 descriptions.
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  • GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 654 amino acids

    Gene Ontology:
    Cellular Component: intracellular [TASLink to PubMed article]
    Biological Process: small GTPase mediated signal transduction [IPILink to PubMed article]
    actin filament reorganization involved in cell cycle [IMPLink to PubMed article]
    Molecular Function: Rho GTPase activator activity [IDALink to PubMed article]
    signal transducer activity [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPNNTLKQGS KIENVSPSKG HVPSFWKQFI NNPKSMSSEN ITVPRSPTSL SRNAQPTTLK  60
   61 RPPLSSRPYS YNTPTKDRKS FSKSAKQNNN NNNANSGTSP HAEFKNYRDM FLSNRNGFTG 120
  121 RVFGVTLAES LSVASAEVIV QSELVSFGRI PIVVAKCGAY LKANGLETSG IFRIAGNGKR 180
  181 VKALQYIFSS PPDYGTKFND WETYTVHDVA SLLRRYLNNL AEPLIPLSLY EQFRNPLRSR 240
  241 PRILRHMLTH EVSHPNANKT NNVTVKSSRQ NYNDDGANDG DIEKEDAKDD EEKRRRKIRH 300
  301 KRRLTRDIRA AIKEYEELFV TLSNDTKQLT IYLLDLLSLF ARQSQFNLMS GRNLAAIFQP 360
  361 SILSHPQHDM DPKEYELSRL VVEFLIEYSY KLLPHLLKLA KREQQERLST ENKKNNGDKQ 420
  421 KTDPIEIPKI TSSDSPPIVS SNKNPPAIDN NNKLDHTTLS PISTSIPENS SDLQTSKMLK 480
  481 PPKQRRPHSK SFGSTPVPPD VIASNKRRTS LFPWLHKPGI LSDTGDNGDL TATEAEGDDY 540
  541 EEENVDPYGQ SPSSVHSGSL PKQHYLPIPR MNRSLSGNST NSSFNTRPIS MILTSGNDNS 600
  601 ADQLELLSNT HSNNERSNAL PLTEDDGDER NSRSRKRESW FQRLTSRSGS ANRA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SAC7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..68] deduced N/A No confident structure predictions are available.
    2 View Details [69..221] PSI-BLAST 89.30103 p50 RhoGAP domain
    3 View Details [222..324] PSI-BLAST 89.30103 p50 RhoGAP domain
    4 View Details [325..434] ORFEUS 10.82 p85 alpha subunit RhoGAP domain
    5 View Details [435..654] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • Rho GTPase activator activity
    		•  4.58620967349979 bayes_pls_golite062009
  • Rac GTPase activator activity
    		•  3.29568423512865 bayes_pls_golite062009
  • GTPase regulator activity
    		•  2.70614727793157 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  2.68579854252375 bayes_pls_golite062009
  • binding
    		•  2.15139804299723 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  2.06038764955701 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.9750017471254 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.95738547986197 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.40452907766862 bayes_pls_golite062009
  • protein binding
    		•  1.29100556128076 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  1.09070479183477 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.03886555863373 bayes_pls_golite062009
  • Ras guanyl-nucleotide exchange factor activity
    		•  0.958295643211986 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.924382263852473 bayes_pls_golite062009
  • actin binding
    		•  0.834823471990077 bayes_pls_golite062009
  • DNA binding
    		•  0.748649183906122 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.717730683557543 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.298334474872045 bayes_pls_golite062009
  • catalytic activity
    		•  0.194464246602439 bayes_pls_golite062009
  • transcription factor activity
    		•  0.124467557925988 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle