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Protein Overview: MCD1

General Information:
Name(s) found: MCD1 / YDL003W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Essential subunit of the cohesin complex required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 566 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    nuclear cohesin complex [TASLink to PubMed article]
    Biological Process: mitotic chromosome condensation [IMPLink to PubMed article]
    mitotic sister chromatid cohesion [IMPLink to PubMed articleLink to PubMed article][TASLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVTENPQRLT VLRLATNKGP LAQIWLASNM SNIPRGSVIQ THIAESAKEI AKASGCDDES  60
   61 GDNEYITLRT SGELLQGIVR VYSKQATFLL TDIKDTLTKI SMLFKTSQKM TSTVNRLNTV 120
  121 TRVHQLMLED AVTEREVLVT PGLEFLDDTT IPVGLMAQEN SMERKVQGAA PWDTSLEVGR 180
  181 RFSPDEDFEH NNLSSMNLDF DIEEGPITSK SWEEGTRQSS RNFDTHENYI QDDDFPLDDA 240
  241 GTIGWDLGIT EKNDQNNDDD DNSVEQGRRL GESIMSEEPT DFGFDLDIEK EAPAGNIDTI 300
  301 TDAMTESQPK QTGTRRNSKL LNTKSIQIDE ETENSESIAS SNTYKEERSN NLLTPQPTNF 360
  361 TTKRLWSEIT ESMSYLPDPI LKNFLSYESL KKRKIHNGRE GSIEEPELNV SLNLTDDVIS 420
  421 NAGTNDNSFN ELTDNMSDFV PIDAGLNEAP FPEENIIDAK TRNEQTTIQT EKVRPTPGEV 480
  481 ASKAIVQMAK ILRKELSEEK EVIFTDVLKS QANTEPENIT KREASRGFFD ILSLATEGCI 540
  541 GLSQTEAFGN IKIDAKPALF ERFINA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) IRR1 MCD1 SMC1 SMC3
    View Details (MIPS) Mewes HW, et al. (2004) IRR1 MCD1 REC8 SCC2 SMC1 SMC3
    View Details Krogan NJ, et al. (2006) IRR1 MCD1 SMC1 SMC3
    View Details Gavin AC, et al. (2002) CCT8 GCN1 HHF1, HHF2 IRR1 KAP123 MCD1 NOP12 RVB2 SCC4 SMC1 SMC3 YHB1
    View Details Ho Y, et al. (2002) CDC5 IRR1 IVY1 KAP95 MCD1 NOP13 SMC1 SMC3 SPC72 SRP1
    View Details Qiu et al. (2008) MCD1 SCC2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen MCD1 SIR3 1 Unpublished Fields Lab Data
    View Screen MCD1 GAL11 1 Unpublished Fields Lab Data
    View Screen MCD1 TAZ1 1 Unpublished Fields Lab Data
    View Screen SPO1 MCD1 1 Unpublished Fields Lab Data
    View Screen MCD1 CCR4 1 Unpublished Fields Lab Data
    View Screen MCD1 YDR366C 1 Unpublished Fields Lab Data
    View Screen MCD1 ADE8 1 Unpublished Fields Lab Data
    View Screen MCD1 SAM2 1 Unpublished Fields Lab Data
    View Screen MCD1 TUB2 1 Unpublished Fields Lab Data
    View Screen MCD1 OCT1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MCD1 Sundin BA, et al. (2004)
    View Data MCD1 Sundin BA, et al. (2004)
    View Data MCD1 Sundin BA, et al. (2004)
    View Data MCD1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..210] MSA 5.024974 View MSA. No confident structure predictions are available.
    2 View Details [211..566] deduced N/A No confident structure predictions are available.
    3 View Details [219..380] MSA 1.070972 View MSA. No confident structure predictions are available.
    4 View Details [381..566] PSI-BLAST 46.045757 Sc Smc1hd:Scc1-C complex, ATPgS

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • DNA binding
    		•  3.84008666671174 bayes_pls_golite062009
  • binding
    		•  3.38086362981788 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.53725013788849 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.4191162518892 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.23378431307469 bayes_pls_golite062009
  • transcription factor activity
    		•  1.63317649552979 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.38449475025903 bayes_pls_golite062009
  • protein binding
    		•  0.961087148890615 bayes_pls_golite062009
  • transcription activator activity
    		•  0.774002575315721 bayes_pls_golite062009
  • transcription factor binding
    		•  0.68991166927379 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.683954534315832 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.52992575338445 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.349632742873003 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.140777233468428 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle