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Protein Overview: OCT1

General Information:
Name(s) found: OCT1 / YKL134C [SGD]
Description(s) found:
Found 16 descriptions.
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  • Mitochondrial intermediate peptidase, cleaves N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 770 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article]
    Biological Process: cellular iron ion homeostasis [IGILink to PubMed article][IMPLink to PubMed article]
    protein processing involved in protein targeting to mitochondrion [IMPLink to PubMed article]
    Molecular Function: mitochondrial intermediate peptidase activity [IDALink to PubMed article][IMPLink to PubMed article]
    metallopeptidase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRTIILKAG SNASIPSPSR QNKLLRFFAT AGAVSRTSPG SIKKIFDDNS YWRNINGQDA  60
   61 NNSKISQYLF KKNKTGLFKN PYLTSPDGLR KFSQVSLQQA QELLDKMRND FSESGKLTYI 120
  121 MNLDRLSDTL CRVIDLCEFI RSTHPDDAFV RAAQDCHEQM FEFMNVLNTD VSLCNILKSV 180
  181 LNNPEVSSKL SAEELKVGKI LLDDFEKSGI YMNPDVREKF IQLSQEISLV GQEFINHTDY 240
  241 PGSNSVKIPC KDLDNSKVST FLLKQLNKDV KGQNYKVPTF GYAAYALLKS CENEMVRKKL 300
  301 WTALHSCSDK QVKRLSHLIK LRAILANLMH KTSYAEYQLE GKWQDRRCQD FILTLMNNTI 360
  361 EKTANELKFI AELKAKDLKK PLTTNTDEIL KLVRPWDRDY YTGKYFQLNP SNSPNAKEIS 420
  421 YYFTLGNVIQ GLSDLFQQIY GIRLEPAITD EGETWSPDVR RLNVISEEEG IIGIIYCDLF 480
  481 ERNGKTSNPA HFTVCCSRQI YPSETDFSTI QVGENPDGTY FQLPVISLVC NFSPILIASK 540
  541 KSLCFLQLSE VETLFHEMGH AMHSMLGRTH MQNISGTRCA TDFVELPSIL MEHFAKDIRI 600
  601 LTKIGKHYGT GETIQADMLQ RFMKSTNFLQ NCETYSQAKM AMLDQSFHDE KIISDIDNFD 660
  661 VVENYQALER RLKVLVDDQS NWCGRFGHLF GSGQLITATY FDRTIASKIW YALFEDDPYS 720
  721 RKNGDKFKKH LLKWGGLKDP WKCIADVLEC PMLEKGGSDA MEFIAQSHKS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen ATG7 OCT1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data OCT1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..84] deduced N/A No confident structure predictions are available.
    2 View Details [85..412]
    [628..698]    		 PSI-BLAST 1300.0 Neurolysin (endopeptidase 24.16)
    3 View Details [413..627]
    [699..770]    		 PSI-BLAST 1300.0 Neurolysin (endopeptidase 24.16)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.65

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle