Protein Overview: OCT1

General Information:
Name(s) found:	OCT1 / YKL134C [SGD]
Description(s) found: Found 16 descriptions. SHOW ALL	Mitochondrial intermediate peptidase, cleaves N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis [SGD]
Organism:	Saccharomyces cerevisiae
Length:	770 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA][IGI][IMP]
Biological Process:	cellular iron ion homeostasis [IGI][IMP] protein processing involved in protein targeting to mitochondrion [IMP]
Molecular Function:	mitochondrial intermediate peptidase activity [IDA][IMP] metallopeptidase activity [IDA][IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRTIILKAG SNASIPSPSR QNKLLRFFAT AGAVSRTSPG SIKKIFDDNS YWRNINGQDA  60
   61 NNSKISQYLF KKNKTGLFKN PYLTSPDGLR KFSQVSLQQA QELLDKMRND FSESGKLTYI 120
  121 MNLDRLSDTL CRVIDLCEFI RSTHPDDAFV RAAQDCHEQM FEFMNVLNTD VSLCNILKSV 180
  181 LNNPEVSSKL SAEELKVGKI LLDDFEKSGI YMNPDVREKF IQLSQEISLV GQEFINHTDY 240
  241 PGSNSVKIPC KDLDNSKVST FLLKQLNKDV KGQNYKVPTF GYAAYALLKS CENEMVRKKL 300
  301 WTALHSCSDK QVKRLSHLIK LRAILANLMH KTSYAEYQLE GKWQDRRCQD FILTLMNNTI 360
  361 EKTANELKFI AELKAKDLKK PLTTNTDEIL KLVRPWDRDY YTGKYFQLNP SNSPNAKEIS 420
  421 YYFTLGNVIQ GLSDLFQQIY GIRLEPAITD EGETWSPDVR RLNVISEEEG IIGIIYCDLF 480
  481 ERNGKTSNPA HFTVCCSRQI YPSETDFSTI QVGENPDGTY FQLPVISLVC NFSPILIASK 540
  541 KSLCFLQLSE VETLFHEMGH AMHSMLGRTH MQNISGTRCA TDFVELPSIL MEHFAKDIRI 600
  601 LTKIGKHYGT GETIQADMLQ RFMKSTNFLQ NCETYSQAKM AMLDQSFHDE KIISDIDNFD 660
  661 VVENYQALER RLKVLVDDQS NWCGRFGHLF GSGQLITATY FDRTIASKIW YALFEDDPYS 720
  721 RKNGDKFKKH LLKWGGLKDP WKCIADVLEC PMLEKGGSDA MEFIAQSHKS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#29 Asynchronous Prep5-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	ATG7	OCT1	2	Unpublished Fields Lab Data
View Screen	MCD1	OCT1	1	Unpublished Fields Lab Data
View Screen	CHL4	OCT1	1	Unpublished Fields Lab Data
View Screen	CTF13	OCT1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	OCT1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..84]	deduced	N/A	No confident structure predictions are available.
2	View Details	[85..412] [628..698]	PSI-BLAST	1300.0	Neurolysin (endopeptidase 24.16)
3	View Details	[413..627] [699..770]	PSI-BLAST	1300.0	Neurolysin (endopeptidase 24.16)

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.65

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2