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Protein Overview: COX2

General Information:
Name(s) found: COX2 / Q0250 [SGD]
Description(s) found:
Found 26 descriptions.
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  • Subunit II of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 251 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    mitochondrial respiratory chain complex IV [IPILink to PubMed article]
    Biological Process: mitochondrial electron transport, cytochrome c to oxygen [IDALink to PubMed article]
    aerobic respiration [IMPLink to PubMed article]
    Molecular Function: cytochrome-c oxidase activity [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLDLLRLQLT TFIMNDVPTP YACYFQDSAT PNQEGILELH DNIMFYLLVI LGLVSWMLYT  60
   61 IVMTYSKNPI AYKYIKHGQT IEVIWTIFPA VILLIIAFPS FILLYLCDEV ISPAMTIKAI 120
  121 GYQWYWKYEY SDFINDSGET VEFESYVIPD ELLEEGQLRL LDTDTSMVVP VDTHIRFVVT 180
  181 AADVIHDFAI PSLGIKVDAT PGRLNQVSAL IQREGVFYGA CSELCGTGHA NMPIKIEAVS 240
  241 LPKFLEWLNE Q

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) COX1 COX12 COX13 COX2 COX3 COX4 COX5A COX6 COX7 COX8 COX9
    View Details Krogan NJ, et al. (2006) ARF2 COX2 MMF1 SLN1 YDR018C YDR374C
    View Details Qiu et al. (2008) AAC1 AAC3 ATP1 ATP14 ATP15 ATP16 ATP17 ATP18 ATP19 ATP2 ATP20 ATP4 ATP5 ATP6 ATP7 ATP8 COB COR1 COX1 COX11 COX12 COX13 COX2 COX3 COX4 COX5A COX5B COX6 COX7 COX8 COX9 CYB2 CYB5 CYC1 CYC7 CYT1 MCR1 MDL2 OLI1 QCR10 QCR2 QCR6 QCR7 QCR8 QCR9 RIP1 SDH1 SDH2 SDH3 SDH4 STF1 STF2 TAZ1 TIM11

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..251] PSI-BLAST 64.522879 Cytochrome c oxidase; Mitochondrial cytochrome c oxidase, subunit II

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • heme-copper terminal oxidase activity
    		•  11.9675111703706 bayes_pls_golite062009
  • cytochrome-c oxidase activity
    		•  11.8880744416502 bayes_pls_golite062009
  • oxidoreductase activity, acting on heme group of donors, oxygen as acceptor
    		•  11.8880744416502 bayes_pls_golite062009
  • oxidoreductase activity, acting on heme group of donors
    		•  11.8880744416502 bayes_pls_golite062009
  • oxidoreductase activity
    		•  5.65538295246639 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  5.58345655724775 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  5.42917542404103 bayes_pls_golite062009
  • oxidoreductase activity, acting on diphenols and related substances as donors
    		•  5.29537051871239 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  5.16682116741947 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  4.89891856458607 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  4.69052551796432 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  4.2605366734397 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  4.04391929184076 bayes_pls_golite062009
  • electron carrier activity
    		•  1.92012405624998 bayes_pls_golite062009
  • binding
    		•  0.910231434235845 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.50970361410839 bayes_pls_golite062009
  • kinase activity
    		•  0.487072060813572 bayes_pls_golite062009
  • protein kinase activity
    		•  0.436639038220637 bayes_pls_golite062009
  • catalytic activity
    		•  0.363071622766357 bayes_pls_golite062009
  • oxidoreduction-driven active transmembrane transporter activity
    		•  0.35835230050467 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.325944931150435 bayes_pls_golite062009
  • protein binding
    		•  0.31459442397123 bayes_pls_golite062009
  • ephrin receptor binding
    		•  0.0573211102210707 bayes_pls_golite062009
  • receptor binding
    		•  0.02789117638033 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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