YRC Public Data Repository - Protein Structure Prediction

Protein:	rab-11.1
Organism:	Caenorhabditis elegans
Length:	211 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for rab-11.1.

Description	E-value	Query Range	Subject Range
rab-1 - RAS-related protein status:Confirmed UniProt:Q9UAQ6 protein_id:AAC69218.1	230.0	[0..1]	[209..1]
CRE16067, FL81_1... - RP15185 WBGene00061078 locus:Cre-rab-1 status:Confirmed, null gi\|157761211 - gi\|157761211\|ref\|XP_001672948.1\| Hypothetical protein CBG01077 [Caenorhabditis briggsae AF16] gi\|39588485, gi\|... - gi\|39588485\|emb\|CAE58008.1\| Hypothetical protein CBG01077 [Caenorhabditis briggsae], gi\|187038224\|em...	230.0	[0..1]	[209..1]
gi\|148230336, gi... - gi\|27924279\|gb\|AAH45014.1\| Rab1-prov protein [Xenopus laevis], gi\|148230336\|ref\|NP_001080138.1\| RAB1... gi\|52345478, gi\|... - gi\|52345478\|ref\|NP_001004787.1\| RAB1A, member RAS oncogene family [Xenopus (Silurana) tropicalis], g...	229.0	[0..1]	[209..1]
gi\|61365844, gi\|... - gi\|61365844\|gb\|AAX42772.1\| RAB1A member RAS oncogene family [synthetic construct], gi\|54695924\|gb\|AA...	229.0	[0..1]	[210..1]
gi\|109081641 - gi\|109081641\|ref\|XP_001103732.1\| PREDICTED: similar to RAB11a, member RAS oncogene family [Macaca mu...	228.0	[0..1]	[209..89]
gi\|53733986 - gb\|AAH83951.1\| Unknown (protein for MGC:97957) [Xenopus laevis] gi\|55741705 - ref\|NP_001003153.1\| RAB1A, member RAS oncogene family [Canis familiaris] gi\|120419448, gi... - gi\|76629653\|ref\|XP_869337.1\| PREDICTED: similar to RAB1, member RAS oncogene family isoform 2 [Bos t... gi\|109103156 - gi\|109103156\|ref\|XP_001090072.1\| PREDICTED: similar to RAB1, member RAS oncogene family isoform 4 [M... gi\|61355917, gi\|... - gi\|61355926\|gb\|AAX41191.1\| RAB1A member RAS oncogene family [synthetic construct], gi\|61355917\|gb\|AA... tr\|G1TCS8\|G1TCS8... - pep:novel chromosome:oryCun2:2:121177308:121212010:1 gene:ENSOCUG00000017003 transcript:ENSOCUT00000... RAB1A - RAB1A, member RAS oncogene family RAB1A_RAT - Ras-related protein Rab-1A OS=Rattus norvegicus GN=Rab1A PE=1 SV=3 RAB1A_CANLF - Ras-related protein Rab-1A OS=Canis lupus familiaris GN=RAB1A PE=1 SV=3 gi\|159906367 - gi\|159906367\|gb\|ABX10872.1\| RAB1A [Capra hircus] RAB1A_MOUSE - Ras-related protein Rab-1A OS=Mus musculus GN=Rab1A PE=1 SV=3 tr\|M3VYP9\|M3VYP9... - RAB1A, member RAS oncogene family OS=Felis catus GN=RAB1A PE=4 SV=1 gi\|149727528 - gi\|149727528\|ref\|XP_001493347.1\| PREDICTED: similar to RAB1A, member RAS oncogene family [Equus caba...	228.0	[0..1]	[209..1]
gi\|37360618 - gi\|37360618\|dbj\|BAC98287.1\| mKIAA3012 protein [Mus musculus]	227.0	[0..1]	[209..49]
RAB1A_LYMST - Ras-related protein Rab-1A OS=Lymnaea stagnalis GN=RAB1A PE=2 SV=1	227.0	[0..1]	[209..1]
RAB1A_PIG - Ras-related protein Rab-1A OS=Sus scrofa GN=RAB1A PE=2 SV=3	227.0	[0..1]	[209..1]
gi\|2144601, gi\|2... - pir\|\|TVRTYP GTP-binding protein Rab1 - rat, gi\|206553\|gb\|AAA42006.1\| ras protein	226.0	[0..1]	[209..1]

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Predicted Domain #1

Region A:
Residues: [1-211]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT RSISVEGKTV  60
   61 KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHVTYE NVERWLKELR DHADQNIVIM 120
  121 LVGNKSDLRH LRAVPTDEAK IYAERNQLSF IETSALDSTN VEAAFTNILT EIYKSVSNKH 180
  181 VGTDRQGYGG GSGTIIPSPA SDPPKKQCCI P

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	55.0
Match:	1oivA
Description:	X-ray structure of the small G protein Rab11a in complex with GDP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
structural constituent of ribosome	5.41178688428159	bayes_pls_golite062009
GTPase activity	4.52394549632777	bayes_pls_golite062009
microtubule motor activity	4.51968578934603	bayes_pls_golite062009
structural molecule activity	4.44501073718522	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	4.26230696590213	bayes_pls_golite062009
motor activity	4.04927796049806	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.4837867129694	bayes_pls_golite062009
	3.39490870259223	bayes_pls_golite062009
ion transmembrane transporter activity	3.35436118751376	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	3.35170865169069	bayes_pls_golite062009
actin binding	3.33639699088484	bayes_pls_golite062009
microfilament motor activity	3.17800963620802	bayes_pls_golite062009
transporter activity	3.10463051760206	bayes_pls_golite062009
cation transmembrane transporter activity	3.08390071341252	bayes_pls_golite062009
transmembrane transporter activity	2.95886887664984	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.95079405147356	bayes_pls_golite062009
metal ion transmembrane transporter activity	2.88476360771975	bayes_pls_golite062009
pyrophosphatase activity	2.87427509025394	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.85499564954033	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.85178667290149	bayes_pls_golite062009
hydrolase activity	2.73675310079844	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.67957846350199	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	2.67815672695824	bayes_pls_golite062009
tubulin binding	2.67743463093593	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	2.66230364606923	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
primary active transmembrane transporter activity	2.61775212528604	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	2.61467977505707	bayes_pls_golite062009
microtubule binding	2.59155206524122	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	2.57552435627908	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	2.57107347424517	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	2.57054427875021	bayes_pls_golite062009
nucleic acid binding	2.51683451033161	bayes_pls_golite062009
active transmembrane transporter activity	2.50494515048649	bayes_pls_golite062009
ATPase activity, coupled	2.43862163407966	bayes_pls_golite062009
cytoskeletal protein binding	2.4101693596493	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.40292717311506	bayes_pls_golite062009
ATPase activity	2.39535714892224	bayes_pls_golite062009
G-protein coupled receptor activity	2.3505608190884	bayes_pls_golite062009
amine transmembrane transporter activity	2.29486577878686	bayes_pls_golite062009
actin filament binding	2.24723363507804	bayes_pls_golite062009
DNA binding	2.12258000781149	bayes_pls_golite062009
transcription regulator activity	2.09345198747025	bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism	1.95782378818812	bayes_pls_golite062009
substrate-specific transporter activity	1.91091452720653	bayes_pls_golite062009
guanyl nucleotide binding	1.89320355239381	bayes_pls_golite062009
guanyl ribonucleotide binding	1.88721318481223	bayes_pls_golite062009
GTP binding	1.87900088157196	bayes_pls_golite062009
purine ribonucleotide binding	1.85943679361938	bayes_pls_golite062009
ribonucleotide binding	1.85937484083653	bayes_pls_golite062009
purine nucleotide binding	1.8521191028835	bayes_pls_golite062009
nucleotide binding	1.84603132945448	bayes_pls_golite062009
kinase activity	1.80889641165674	bayes_pls_golite062009
structural constituent of muscle	1.75982319871463	bayes_pls_golite062009
protein transporter activity	1.71214667007262	bayes_pls_golite062009
helicase activity	1.70242731830224	bayes_pls_golite062009
RNA binding	1.60613159109369	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.60386625568858	bayes_pls_golite062009
amino acid transmembrane transporter activity	1.59627719545436	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.58971273330352	bayes_pls_golite062009
actin-dependent ATPase activity	1.58897222423517	bayes_pls_golite062009
ATP binding	1.5859264197035	bayes_pls_golite062009
adenyl ribonucleotide binding	1.55520429131224	bayes_pls_golite062009
adenyl nucleotide binding	1.53158018507951	bayes_pls_golite062009
GDP-dissociation inhibitor binding	1.53046363842187	bayes_pls_golite062009
apolipoprotein receptor activity	1.52496551152043	bayes_pls_golite062009
syntaxin-13 binding	1.52496551152043	bayes_pls_golite062009
apolipoprotein A-I binding	1.52496551152043	bayes_pls_golite062009
apolipoprotein A-I receptor activity	1.52496551152043	bayes_pls_golite062009
signal recognition particle binding	1.46975774710831	bayes_pls_golite062009
antigen binding	1.43656260286121	bayes_pls_golite062009
RNA helicase activity	1.42791449104435	bayes_pls_golite062009
RNA-dependent ATPase activity	1.39335733374328	bayes_pls_golite062009
plus-end-directed microtubule motor activity	1.38366133153678	bayes_pls_golite062009
ATP-dependent RNA helicase activity	1.36724390116598	bayes_pls_golite062009
cation channel activity	1.33585529285301	bayes_pls_golite062009
transmembrane receptor activity	1.26314334516725	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	1.23799860254751	bayes_pls_golite062009
copper ion transmembrane transporter activity	1.23706764781183	bayes_pls_golite062009
GMP binding	1.22634924609704	bayes_pls_golite062009
protein binding	1.22129154759482	bayes_pls_golite062009
DNA-dependent ATPase activity	1.2155186842031	bayes_pls_golite062009
receptor activity	1.20313362488821	bayes_pls_golite062009
ATP-dependent helicase activity	1.19311444180077	bayes_pls_golite062009
purine NTP-dependent helicase activity	1.19311444180077	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.14475274823167	bayes_pls_golite062009
signal transducer activity	1.13474466330485	bayes_pls_golite062009
molecular transducer activity	1.13474466330485	bayes_pls_golite062009
protein kinase activity	1.12864835254143	bayes_pls_golite062009
ADP binding	1.10601354993582	bayes_pls_golite062009
nucleotide kinase activity	1.10251779925246	bayes_pls_golite062009
beta-catenin binding	1.03146778136145	bayes_pls_golite062009
voltage-gated cation channel activity	1.00384984515681	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
DNA-directed DNA polymerase activity	0.971476020912368	bayes_pls_golite062009
DNA polymerase activity	0.928091843881235	bayes_pls_golite062009
GBD domain binding	0.914270985726459	bayes_pls_golite062009
transcription activator activity	0.889929694023098	bayes_pls_golite062009
voltage-gated ion channel activity	0.889208591820696	bayes_pls_golite062009
transcription factor activity	0.887108427603557	bayes_pls_golite062009
protein methyltransferase activity	0.876296121718575	bayes_pls_golite062009
voltage-gated channel activity	0.871525745291603	bayes_pls_golite062009
transcription repressor activity	0.862685397469217	bayes_pls_golite062009
ion channel activity	0.848261056209476	bayes_pls_golite062009
channel activity	0.806331380134838	bayes_pls_golite062009
passive transmembrane transporter activity	0.806331380134838	bayes_pls_golite062009
substrate-specific channel activity	0.799997700906738	bayes_pls_golite062009
structure-specific DNA binding	0.782430219754236	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	0.767424210804186	bayes_pls_golite062009
DNA helicase activity	0.72881469450553	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	0.69784475011795	bayes_pls_golite062009
potassium channel activity	0.694411056320469	bayes_pls_golite062009
protein-DNA loading ATPase activity	0.650964453464311	bayes_pls_golite062009
gated channel activity	0.650050847753837	bayes_pls_golite062009
steroid hormone receptor binding	0.647625526012423	bayes_pls_golite062009
calcium channel activity	0.636216614902039	bayes_pls_golite062009
histone methyltransferase activity	0.63002958837536	bayes_pls_golite062009
double-stranded DNA binding	0.6071273686445	bayes_pls_golite062009
ATP-dependent DNA helicase activity	0.5886142102548	bayes_pls_golite062009
sterol transporter activity	0.57614280790431	bayes_pls_golite062009
anion transmembrane-transporting ATPase activity	0.563503770238611	bayes_pls_golite062009
sequence-specific DNA binding	0.543891899378373	bayes_pls_golite062009
DNA clamp loader activity	0.543512707823441	bayes_pls_golite062009
ribonucleoprotein binding	0.53788302029845	bayes_pls_golite062009
DNA strand annealing activity	0.495691434532349	bayes_pls_golite062009
protein transmembrane transporter activity	0.46552249844591	bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity	0.442220326523999	bayes_pls_golite062009
monosaccharide transmembrane transporter activity	0.439781986921438	bayes_pls_golite062009
anion transmembrane transporter activity	0.43332053110728	bayes_pls_golite062009
signal sequence binding	0.42240724331108	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	0.40217318916177	bayes_pls_golite062009
drug transmembrane transporter activity	0.38711726712063	bayes_pls_golite062009
hormone receptor binding	0.351501100511918	bayes_pls_golite062009
histone acetyltransferase activity	0.349068554352804	bayes_pls_golite062009
lysine N-acetyltransferase activity	0.349068554352804	bayes_pls_golite062009
protein serine/threonine kinase activity	0.345873656782869	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.328170855722634	bayes_pls_golite062009
receptor binding	0.309955875731734	bayes_pls_golite062009
peptide binding	0.304703625340488	bayes_pls_golite062009
translation regulator activity	0.29096092258568	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.274994961137851	bayes_pls_golite062009
myosin binding	0.274885859454447	bayes_pls_golite062009
voltage-gated calcium channel activity	0.25979628626254	bayes_pls_golite062009
nuclear hormone receptor binding	0.246160342138071	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.243902356228423	bayes_pls_golite062009
amino acid-transporting ATPase activity	0.147644650870465	bayes_pls_golite062009
amine-transporting ATPase activity	0.135455889967401	bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity	0.12351419478929	bayes_pls_golite062009
cation-transporting ATPase activity	0.0536898657672154	bayes_pls_golite062009
G-protein-coupled receptor binding	0.0436504490626262	bayes_pls_golite062009
structural constituent of cytoskeleton	0.0111338193708552	bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity	0.00571427458217011	bayes_pls_golite062009
macromolecule transmembrane transporter activity	0.00571427458217011	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: