YRC Public Data Repository - Protein Structure Prediction

Protein:	TOR1
Organism:	Saccharomyces cerevisiae
Length:	2470 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TOR1.

Description	E-value	Query Range	Subject Range
TOR2 - PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth i... TOR2_YEAST - Serine/threonine-protein kinase TOR2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TOR...	0.0	[37..2470]	[42..2474]
MTOR_RAT - Serine/threonine-protein kinase mTOR OS=Rattus norvegicus GN=Mtor PE=1 SV=1	0.0	[72..2470]	[20..2549]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[78..2470]	[4..2337]
gi\|447739 - gi\|447739\|prf\|\|1915304A nylB upstream ORF	0.0	[37..2470]	[42..2474]
MTOR - mechanistic target of rapamycin (serine/threonine kinase)	0.0	[72..2470]	[20..2549]
TOR_ARATH - Serine/threonine-protein kinase TOR OS=Arabidopsis thaliana GN=TOR PE=1 SV=1	0.0	[54..2470]	[22..2481]

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Predicted Domain #1

Region A:
Residues: [1-85]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPHEEQIWK SKLLKAANND MDMDRNVPLA PNLNVNMNMK MNASRNGDEF GLTSSRFDGV  60
   61 VIGSNGDVNF KPILEKIFRE LTSDY

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [86-322]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEERKLASIS LFDLLVSLEH ELSIEEFQAV SNDINNKILE LVHTKKTSTR VGAVLSIDTL  60
   61 ISFYAYTERL PNETSRLAGY LRGLIPSNDV EVMRLAAKTL GKLAVPGGTY TSDFVEFEIK 120
  121 SCLEWLTAST EKNSFSSSKP DHAKHAALLI ITALAENCPY LLYQYLNSIL DNIWRALRDP 180
  181 HLVIRIDASI TLAKCLSTLR NRDPQLTSQW VQRLATSCEY GFQVNTLECI HASLLVY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	81.221849
Match:	1qgkA_
Description:	Importin beta
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein transporter activity	3.92743254165888	bayes_pls_golite062009
binding	3.0667965351474	bayes_pls_golite062009
clathrin binding	3.06608550312523	bayes_pls_golite062009
protein binding	2.78733902345842	bayes_pls_golite062009
transporter activity	2.48700774379895	bayes_pls_golite062009
nucleic acid binding	2.33018407596597	bayes_pls_golite062009
substrate-specific transporter activity	2.26725422172281	bayes_pls_golite062009
transcription regulator activity	2.16673352512615	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	1.81975432004022	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.77299972560401	bayes_pls_golite062009
DNA binding	1.7075005295555	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.62227684952907	bayes_pls_golite062009
kinase activity	1.60994283310715	bayes_pls_golite062009
hydrolase activity	1.50413178466141	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.50380925936701	bayes_pls_golite062009
protein kinase activity	1.39674032951965	bayes_pls_golite062009
transmembrane transporter activity	1.28481004323799	bayes_pls_golite062009
transferase activity	1.25186057612742	bayes_pls_golite062009
cell adhesion molecule binding	1.10202633941671	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.09652988954158	bayes_pls_golite062009
molecular transducer activity	1.05960420053443	bayes_pls_golite062009
signal transducer activity	1.05960420053443	bayes_pls_golite062009
transcription factor activity	1.00193525671783	bayes_pls_golite062009
cytoskeletal protein binding	0.773975545005505	bayes_pls_golite062009
protein transmembrane transporter activity	0.77052454980864	bayes_pls_golite062009
enzyme regulator activity	0.698613639309592	bayes_pls_golite062009
protein phosphatase binding	0.67117954368313	bayes_pls_golite062009
protein serine/threonine kinase activity	0.638990331710836	bayes_pls_golite062009
actin binding	0.572473732371314	bayes_pls_golite062009
phosphatase binding	0.5597863594782	bayes_pls_golite062009
RNA binding	0.40024158562931	bayes_pls_golite062009
structure-specific DNA binding	0.331309559699391	bayes_pls_golite062009
active transmembrane transporter activity	0.252495966234234	bayes_pls_golite062009
ion transmembrane transporter activity	0.248585912061178	bayes_pls_golite062009
primary active transmembrane transporter activity	0.226380819487924	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.217517113570989	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.178770060806735	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.175241020572885	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.174922130116569	bayes_pls_golite062009
transcription activator activity	0.160275383613705	bayes_pls_golite062009
cadherin binding	0.1400783779596	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.100181463251306	bayes_pls_golite062009
nuclear localization sequence binding	0.0935103343162811	bayes_pls_golite062009
pyrophosphatase activity	0.0635404099346928	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0548082069333885	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.052195223119721	bayes_pls_golite062009
kinase binding	0.046676627148301	bayes_pls_golite062009
cation transmembrane transporter activity	0.0405268469927988	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	0.0332743336452223	bayes_pls_golite062009
GTPase regulator activity	0.0268373969988844	bayes_pls_golite062009
transcription factor binding	0.0221966060394205	bayes_pls_golite062009
guanyl ribonucleotide binding	0.00234756529236324	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [323-503]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEILFLKDPF LNQVFDQMCL NCIAYENHKA KMIREKIYQI VPLLASFNPQ LFAGKYLHQI  60
   61 MDNYLEILTN APANKIPHLK DDKPQILISI GDIAYEVGPD IAPYVKQILD YIEHDLQTKF 120
  121 KFRKKFENEI FYCIGRLAVP LGPVLGKLLN RNILDLMFKC PLSDYMQETF QILTERIPSL 180
  181 G

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	81.221849
Match:	1qgkA_
Description:	Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [504-625]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKINDELLNL VCSTLSGTPF IQPGSPMEIP SFSRERAREW RNKNILQKTG ESNDDNNDIK  60
   61 IIIQAFRMLK NIKSRFSLVE FVRIVALSYI EHTDPRVRKL AALTSCEIYV KDNICKQTSL 120
  121 HS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	81.221849
Match:	1qgkA_
Description:	Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [626-760]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNTVSEVLSK LLAITIADPL QDIRLEVLKN LNPCFDPQLA QPDNLRLLFT ALHDESFNIQ  60
   61 SVAMELVGRL SSVNPAYVIP SIRKILLELL TKLKFSTSSR EKEETASLLC TLIRSSKDVA 120
  121 KPYIEPLLNV LLPKF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	81.221849
Match:	1qgkA_
Description:	Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [761-988]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QDTSSTVAST ALRTIGELSV VGGEDMKIYL KDLFPLIIKT FQDQSNSFKR EAALKALGQL  60
   61 AASSGYVIDP LLDYPELLGI LVNILKTENS QNIRRQTVTL IGILGAIDPY RQKEREVTST 120
  121 TDISTEQNAP PIDIALLMQG MSPSNDEYYT TVVIHCLLKI LKDPSLSSYH TAVIQAIMHI 180
  181 FQTLGLKCVS FLDQIIPTIL DVMRTCSQSL LEFYFQQLCS LIIIVRQH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	81.221849
Match:	1qgkA_
Description:	Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #7

Region A:
Residues: [989-1226]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IRPHVDSIFQ AIKDFSSVAK LQITLVSVIE AISKALEGEF KRLVPLTLTL FLVILENDKS  60
   61 SDKVLSRRVL RLLESFGPNL EGYSHLITPK IVQMAEFTSG NLQRSAIITI GKLAKDVDLF 120
  121 EMSSRIVHSL LRVLSSTTSD ELSKVIMNTL SLLLIQMGTS FAIFIPVINE VLMKKHIQHT 180
  181 IYDDLTNRIL NNDVLPTKIL EANTTDYKPA EQMEAADAGV AKLPINQSVL KSAWNSSQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	81.154902
Match:	1b3uA_
Description:	Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
1-phosphatidylinositol-3-kinase activity	6.25653789181171	bayes_pls_golite062009
phosphoinositide 3-kinase activity	6.23876192310792	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
neurexin binding	4.1106220854373	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
lipid kinase activity	3.32869674544617	bayes_pls_golite062009
inositol or phosphatidylinositol kinase activity	3.07779388034304	bayes_pls_golite062009
clathrin binding	3.06608550312523	bayes_pls_golite062009
insulin receptor activity	2.91728725389216	bayes_pls_golite062009
protein tyrosine kinase activity	2.8153155526437	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
PTB domain binding	2.68841114010895	bayes_pls_golite062009
molecular transducer activity	2.40586892801446	bayes_pls_golite062009
signal transducer activity	2.40586892801446	bayes_pls_golite062009
protein binding	2.276111749106	bayes_pls_golite062009
receptor signaling protein activity	2.10379226653669	bayes_pls_golite062009
GTPase activity	2.07905155389729	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
calcium-dependent phospholipid binding	1.85892769686753	bayes_pls_golite062009
phosphoinositide 3-kinase binding	1.82515074380651	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	1.81975432004022	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.81249386965144	bayes_pls_golite062009
transmembrane receptor protein kinase activity	1.7769021678395	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.77299972560401	bayes_pls_golite062009
transmembrane receptor activity	1.6878868450299	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
insulin receptor substrate binding	1.59061960750503	bayes_pls_golite062009
receptor activity	1.57112777506542	bayes_pls_golite062009
transcription regulator activity	1.56748951434625	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	1.4571078357189	bayes_pls_golite062009
peptidase activity	1.4194137915074	bayes_pls_golite062009
kinase binding	1.26086833316556	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
transporter activity	1.11833481501707	bayes_pls_golite062009
DNA binding	1.10840413397037	bayes_pls_golite062009
protein kinase binding	1.06030596516506	bayes_pls_golite062009
nucleic acid binding	1.04820278247375	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	1.02752755983942	bayes_pls_golite062009
transmembrane transporter activity	0.97575992765505	bayes_pls_golite062009
cyclin-dependent protein kinase activity	0.959360414036299	bayes_pls_golite062009
hydrolase activity	0.950393847838778	bayes_pls_golite062009
transcription factor activity	0.904613968623246	bayes_pls_golite062009
protein complex binding	0.810706883199821	bayes_pls_golite062009
protein transmembrane transporter activity	0.77052454980864	bayes_pls_golite062009
3-phosphoinositide-dependent protein kinase binding	0.766462410372719	bayes_pls_golite062009
substrate-specific transporter activity	0.705905455086486	bayes_pls_golite062009
stem cell factor receptor activity	0.702866451999818	bayes_pls_golite062009
transcription repressor activity	0.568332175782799	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.51726292539973	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
enzyme binding	0.46284745266176	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.450699332958421	bayes_pls_golite062009
protein kinase C activity	0.41587987561486	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
insulin receptor binding	0.379040209226037	bayes_pls_golite062009
SNARE binding	0.3731056408292	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
MAP kinase kinase activity	0.35402045013148	bayes_pls_golite062009
protein transporter activity	0.322729515821394	bayes_pls_golite062009
cytoskeletal protein binding	0.284465446035567	bayes_pls_golite062009
structure-specific DNA binding	0.267404531445803	bayes_pls_golite062009
transforming growth factor beta receptor activity	0.26602283402868	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity	0.26602283402868	bayes_pls_golite062009
active transmembrane transporter activity	0.252495966234234	bayes_pls_golite062009
primary active transmembrane transporter activity	0.226380819487924	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.217517113570989	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.178770060806735	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.175241020572885	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.174922130116569	bayes_pls_golite062009
ion transmembrane transporter activity	0.148194101970458	bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate 3-kinase activity	0.147483323744488	bayes_pls_golite062009
actin binding	0.144822861207099	bayes_pls_golite062009
nuclear localization sequence binding	0.0935103343162811	bayes_pls_golite062009
MAP kinase activity	0.08504542461349	bayes_pls_golite062009
growth factor binding	0.0526340287295695	bayes_pls_golite062009
transforming growth factor beta receptor activity, type I	0.0506751594607393	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.0040394359628233	bayes_pls_golite062009
SH2 domain binding	2.96656737540424E-4	bayes_pls_golite062009

Predicted Domain #8

Region A:
Residues: [1227-1323]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QRTKEDWQEW SKRLSIQLLK ESPSHALRAC SNLASMYYPL AKELFNTAFA CVWTELYSQY  60
   61 QEDLIGSLCI ALSSPLNPPE IHQTLLNLVE FMEHDDK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.907	0.002	endosome membrane	a.118.11	Cytochrome c oxidase subunit E

Predicted Domain #9

Region A:
Residues: [1324-1919]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALPIPTQSLG EYAERCHAYA KALHYKEIKF IKEPENSTIE SLISINNQLN QTDAAIGILK  60
   61 HAQQHHSLQL KETWFEKLER WEDALHAYNE REKAGDTSVS VTLGKMRSLH ALGEWEQLSQ 120
  121 LAARKWKVSK LQTKKLIAPL AAGAAWGLGE WDMLEQYISV MKPKSPDKEF FDAILYLHKN 180
  181 DYDNASKHIL NARDLLVTEI SALINESYNR AYSVIVRTQI ITEFEEIIKY KQLPPNSEKK 240
  241 LHYQNLWTKR LLGCQKNVDL WQRVLRVRSL VIKPKQDLQI WIKFANLCRK SGRMRLANKA 300
  301 LNMLLEGGND PSLPNTFKAP PPVVYAQLKY IWATGAYKEA LNHLIGFTSR LAHDLGLDPN 360
  361 NMIAQSVKLS SASTAPYVEE YTKLLARCFL KQGEWRIATQ PNWRNTNPDA ILGSYLLATH 420
  421 FDKNWYKAWH NWALANFEVI SMVQEETKLN GGKNDDDDDT AVNNDNVRID GSILGSGSLT 480
  481 INGNRYPLEL IQRHVVPAIK GFFHSISLLE TSCLQDTLRL LTLLFNFGGI KEVSQAMYEG 540
  541 FNLMKIENWL EVLPQLISRI HQPDPTVSNS LLSLLSDLGK AHPQALVYPL TVAIKS

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	235.376751
Match:	PF02259
Description:	FAT domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10

Region A:
Residues: [1920-2084]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESVSRQKAAL SIIEKIRIHS PVLVNQAELV SHELIRVAVL WHELWYEGLE DASRQFFVEH  60
   61 NIEKMFSTLE PLHKHLGNEP QTLSEVSFQK SFGRDLNDAY EWLNNYKKSK DINNLNQAWD 120
  121 IYYNVFRKIT RQIPQLQTLD LQHVSPQLLA THDLELAVPG TYFPG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	332.30103
Match:	1aueA_
Description:	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
Matching Structure (courtesy of the PDB):

Predicted Domain #11

Region A:
Residues: [2085-2436]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPTIRIAKFE PLFSVISSKQ RPRKFSIKGS DGKDYKYVLK GHEDIRQDSL VMQLFGLVNT  60
   61 LLKNDSECFK RHLDIQQYPA IPLSPKSGLL GWVPNSDTFH VLIREHRDAK KIPLNIEHWV 120
  121 MLQMAPDYEN LTLLQKIEVF TYALDNTKGQ DLYKILWLKS RSSETWLERR TTYTRSLAVM 180
  181 SMTGYILGLG DRHPSNLMLD RITGKVIHID FGDCFEAAIL REKYPEKVPF RLTRMLTYAM 240
  241 EVSGIEGSFR ITCENVMRVL RDNKESLMAI LEAFALDPLI HWGFDLPPQK LTEQTGIPLP 300
  301 LINPSELLRK GAITVEEAAN MEAEQQNETK NARAMLVLRR ITDKLTGNDI KR

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	123.60206
Match:	PF00454
Description:	Phosphatidylinositol 3- and 4-kinase

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #12

Region A:
Residues: [2437-2470]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FNELDVPEQV DKLIQQATSI ERLCQHYIGW CPFW

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	17.130768
Match:	PF02260
Description:	FATC domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: