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View Protein Complex Details

Complex Overview

From Publication: Qiu J, Noble WS (2008) Predicting Co-Complexed Protein Pairs from Heterogeneous Data. PLoS Comput Biol 4(4): e1000054. doi:10.1371/journal.pcbi.1000054
Notes: Classifier used Gene Ontology annotations. [FDR: 0.02] [SVM Score: 1.16349545418]
Complex Size: 2 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
DPB3
  • replication fork
  • epsilon DNA polymerase complex
    		•
  • lagging strand elongation
  • leading strand elongation
  • nucleotide-excision repair
  • mismatch repair
  • chromatin silencing at telomere
    		•
  • DNA binding
  • DNA-directed DNA polymerase activity
  • nucleotidyltransferase activity
  • double-stranded DNA binding
  • transferase activity
    		•
    POL2
  • replication fork
  • epsilon DNA polymerase complex
    		•
  • lagging strand elongation
  • leading strand elongation
  • nucleotide-excision repair
  • mismatch repair
  • DNA synthesis involved in DNA repair
  • chromatin silencing at telomere
    		•
  • nucleotide binding
  • nucleic acid binding
  • DNA binding
  • zinc ion binding
  • DNA-directed DNA polymerase activity
  • nucleotidyltransferase activity
  • metal ion binding
  • double-stranded DNA binding
  • transferase activity
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    epsilon DNA polymerase complex 5.0527E-7 2 5 2 6292
    DNA polymerase complex 2.2737E-6 2 10 2 6292
    nuclear replisome 7.7306E-6 2 18 2 6292
    replisome 7.7306E-6 2 18 2 6292
    nuclear replication fork 9.6001E-6 2 20 2 6292
    nucleotide-excision repair complex 1.0611E-5 2 21 2 6292
    replication fork 4.3504E-5 2 42 2 6292
    protein-DNA complex 8.0641E-5 2 57 2 6292
    nuclear chromosome part 9.0721E-4 2 190 2 6292
    nuclear chromosome 1.3075E-3 2 228 2 6292
    chromosomal part 1.413E-3 2 237 2 6292
    chromosome 1.8898E-3 2 274 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    leading strand elongation 5.3053E-6 2 15 2 6292
    lagging strand elongation 7.7306E-6 2 18 2 6292
    mismatch repair 1.7735E-5 2 27 2 6292
    DNA strand elongation 2.3495E-5 2 31 2 6292
    DNA strand elongation involved in DNA replication 2.3495E-5 2 31 2 6292
    nucleotide-excision repair 3.552E-5 2 38 2 6292
    chromatin silencing at telomere 7.5032E-5 2 55 2 6292
    DNA-dependent DNA replication 1.678E-4 2 82 2 6292
    negative regulation of gene expression, epigenetic 2.5011E-4 2 100 2 6292
    chromatin silencing 2.5011E-4 2 100 2 6292
    gene silencing 2.5011E-4 2 100 2 6292
    regulation of gene expression, epigenetic 2.5011E-4 2 100 2 6292
    DNA replication 3.791E-4 2 123 2 6292
    negative regulation of transcription, DNA-dependent 6.1875E-4 2 157 2 6292
    negative regulation of RNA metabolic process 6.2668E-4 2 158 2 6292
    negative regulation of gene expression 6.7534E-4 2 164 2 6292
    negative regulation of transcription 6.7534E-4 2 164 2 6292
    negative regulation of macromolecule biosynthetic process 7.6927E-4 2 175 2 6292
    negative regulation of nitrogen compound metabolic process 8.1399E-4 2 180 2 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 8.1399E-4 2 180 2 6292
    negative regulation of biosynthetic process 8.9766E-4 2 189 2 6292
    negative regulation of cellular biosynthetic process 8.9766E-4 2 189 2 6292
    DNA repair 9.2646E-4 2 192 2 6292
    negative regulation of macromolecule metabolic process 9.2646E-4 2 192 2 6292
    negative regulation of cellular metabolic process 1.0983E-3 2 209 2 6292
    negative regulation of metabolic process 1.1088E-3 2 210 2 6292
    DNA synthesis involved in DNA repair 1.2712E-3 2 4 1 6292
    response to DNA damage stimulus 1.4011E-3 2 236 2 6292
    negative regulation of cellular process 1.5726E-3 2 250 2 6292
    negative regulation of biological process 1.6107E-3 2 253 2 6292
    cellular response to stress 2.1173E-3 2 290 2 6292
    regulation of transcription, DNA-dependent 3.2288E-3 2 358 2 6292
    regulation of RNA metabolic process 3.3198E-3 2 363 2 6292
    cellular response to stimulus 3.6193E-3 2 379 2 6292
    regulation of transcription 3.7155E-3 2 384 2 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 4.3405E-3 2 415 2 6292
    regulation of nitrogen compound metabolic process 4.3615E-3 2 416 2 6292
    regulation of gene expression 4.9915E-3 2 445 2 6292
    regulation of macromolecule biosynthetic process 5.2416E-3 2 456 2 6292
    regulation of cellular biosynthetic process 5.6164E-3 2 472 2 6292
    regulation of biosynthetic process 5.6402E-3 2 473 2 6292
    regulation of macromolecule metabolic process 6.004E-3 2 488 2 6292
    response to stress 6.2277E-3 2 497 2 6292
    transcription, DNA-dependent 6.3792E-3 2 503 2 6292
    RNA biosynthetic process 6.5067E-3 2 508 2 6292
    regulation of primary metabolic process 6.6615E-3 2 514 2 6292
    regulation of cellular metabolic process 7.2445E-3 2 536 2 6292
    regulation of metabolic process 7.5452E-3 2 547 2 6292
    transcription 7.6839E-3 2 552 2 6292
    DNA metabolic process 8.631E-3 2 585 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    double-stranded DNA binding 1.2783E-5 2 23 2 6292
    structure-specific DNA binding 4.7798E-5 2 44 2 6292
    DNA-directed DNA polymerase activity 3.0291E-4 2 110 2 6292
    DNA polymerase activity 3.312E-4 2 115 2 6292
    nucleotidyltransferase activity 7.0879E-4 2 168 2 6292
    DNA binding 1.6492E-3 2 256 2 6292
    zinc ion binding 2.5415E-3 2 8 1 6292
    transferase activity, transferring phosphorus-containing groups 4.4459E-3 2 420 2 6292
    transition metal ion binding 7.6148E-3 2 24 1 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle