YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Rpc40. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 12 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ACC1
  • endoplasmic reticulum membrane
  • mitochondrion
  • cytosol
  • nuclear envelope organization
  • protein import into nucleus
  • fatty acid biosynthetic process
  • acetyl-CoA carboxylase activity
  • biotin carboxylase activity
  • AHA1
  • cytoplasm
  • protein folding
  • response to stress
  • chaperone binding
  • chaperone activator activity
  • ATPase activator activity
  • ARO4
  • nucleus
  • cytoplasm
  • aromatic amino acid family biosynthetic process
  • 3-deoxy-7-phosphoheptulonate synthase activity
  • CDC60
  • cytoplasm
  • leucyl-tRNA aminoacylation
  • leucine-tRNA ligase activity
  • ILS1
  • cytosol
  • translation
  • isoleucine-tRNA ligase activity
  • RPA135
  • DNA-directed RNA polymerase I complex
  • transcription from RNA polymerase I promoter
  • ribosome biogenesis
  • DNA-directed RNA polymerase activity
  • RPA190
  • DNA-directed RNA polymerase I complex
  • transcription from RNA polymerase I promoter
  • DNA-directed RNA polymerase activity
  • RPC40
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
  • transcription from RNA polymerase III promoter
  • transcription from RNA polymerase I promoter
  • ribosome biogenesis
  • DNA-directed RNA polymerase activity
  • SMC4
  • nuclear condensin complex
  • mitotic chromosome condensation
  • mitotic sister chromatid segregation
  • ATPase activity
  • chromatin binding
  • TRP5
  • nucleus
  • cytoplasm
  • tryptophan biosynthetic process
  • tryptophan synthase activity
  • URE2
  • soluble fraction
  • cytosol
  • response to aluminum ion
  • telomere maintenance
  • regulation of nitrogen utilization
  • protein urmylation
  • cytoplasmic sequestering of transcription factor
  • transcription corepressor activity
  • phosphoprotein binding
  • VMA4
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
  • vacuolar acidification
  • proton-transporting ATPase activity, rotational mechanism
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    DNA-directed RNA polymerase I complex 1.9071E-6 12 14 3 6292
    DNA-directed RNA polymerase complex 2.3125E-5 12 31 3 6292
    RNA polymerase complex 2.3125E-5 12 31 3 6292
    nuclear DNA-directed RNA polymerase complex 2.3125E-5 12 31 3 6292
    nucleolar part 7.191E-5 12 45 3 6292
    nucleolus 6.5368E-3 12 211 3 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    transcription from RNA polymerase I promoter 2.0909E-5 12 30 3 6292
    aromatic amino acid family biosynthetic process 5.0164E-4 12 18 2 6292
    chorismate metabolic process 5.0164E-4 12 18 2 6292
    aromatic amino acid family metabolic process 8.9917E-4 12 24 2 6292
    dicarboxylic acid metabolic process 1.4082E-3 12 30 2 6292
    negative regulation of protein import into nucleus 1.9072E-3 12 1 1 6292
    negative regulation of intracellular transport 1.9072E-3 12 1 1 6292
    negative regulation of intracellular protein transport 1.9072E-3 12 1 1 6292
    negative regulation of nucleocytoplasmic transport 1.9072E-3 12 1 1 6292
    response to aluminum ion 1.9072E-3 12 1 1 6292
    regulation of transcription factor import into nucleus 1.9072E-3 12 1 1 6292
    transcription factor import into nucleus 1.9072E-3 12 1 1 6292
    negative regulation of transcription factor import into nucleus 1.9072E-3 12 1 1 6292
    cytoplasmic sequestering of transcription factor 1.9072E-3 12 1 1 6292
    organic acid biosynthetic process 2.0055E-3 12 139 3 6292
    carboxylic acid biosynthetic process 2.0055E-3 12 139 3 6292
    aromatic compound biosynthetic process 2.4984E-3 12 40 2 6292
    cellular biosynthetic process 2.6841E-3 12 1567 8 6292
    carboxylic acid metabolic process 2.7174E-3 12 333 4 6292
    organic acid metabolic process 2.7174E-3 12 333 4 6292
    oxoacid metabolic process 2.7174E-3 12 333 4 6292
    biosynthetic process 3.1247E-3 12 1602 8 6292
    cellular ketone metabolic process 3.1264E-3 12 346 4 6292
    protein localization in nucleus 3.5826E-3 12 48 2 6292
    protein import into nucleus 3.5826E-3 12 48 2 6292
    nuclear import 3.5826E-3 12 48 2 6292
    regulation of protein import into nucleus 3.811E-3 12 2 1 6292
    regulation of intracellular transport 3.811E-3 12 2 1 6292
    leucyl-tRNA aminoacylation 3.811E-3 12 2 1 6292
    regulation of nucleocytoplasmic transport 3.811E-3 12 2 1 6292
    negative regulation of protein transport 3.811E-3 12 2 1 6292
    cytoplasmic sequestering of protein 3.811E-3 12 2 1 6292
    regulation of intracellular protein transport 3.811E-3 12 2 1 6292
    cellular amino acid metabolic process 5.5509E-3 12 199 3 6292
    regulation of establishment of protein localization 5.7116E-3 12 3 1 6292
    negative regulation of transport 5.7116E-3 12 3 1 6292
    regulation of protein localization 5.7116E-3 12 3 1 6292
    regulation of protein transport 5.7116E-3 12 3 1 6292
    cellular amine metabolic process 7.5284E-3 12 222 3 6292
    regulation of cellular localization 9.5026E-3 12 5 1 6292
    primary metabolic process 9.5102E-3 12 2896 10 6292
    amine metabolic process 9.6619E-3 12 243 3 6292
    cellular amino acid and derivative metabolic process 9.6619E-3 12 243 3 6292
    cellular aromatic compound metabolic process 9.9369E-3 12 81 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA polymerase activity 3.0686E-5 12 34 3 6292
    DNA-directed RNA polymerase activity 3.0686E-5 12 34 3 6292
    catalytic activity 6.7428E-4 12 2150 10 6292
    biotin carboxylase activity 1.9072E-3 12 1 1 6292
    phosphoprotein binding 1.9072E-3 12 1 1 6292
    tryptophan synthase activity 1.9072E-3 12 1 1 6292
    aminoacyl-tRNA ligase activity 2.2566E-3 12 38 2 6292
    ligase activity, forming aminoacyl-tRNA and related compounds 2.2566E-3 12 38 2 6292
    ligase activity, forming carbon-oxygen bonds 2.2566E-3 12 38 2 6292
    ligase activity 2.4944E-3 12 150 3 6292
    nucleotidyltransferase activity 3.4443E-3 12 168 3 6292
    3-deoxy-7-phosphoheptulonate synthase activity 3.811E-3 12 2 1 6292
    leucine-tRNA ligase activity 3.811E-3 12 2 1 6292
    isoleucine-tRNA ligase activity 3.811E-3 12 2 1 6292
    acetyl-CoA carboxylase activity 3.811E-3 12 2 1 6292
    CoA carboxylase activity 3.811E-3 12 2 1 6292
    chaperone activator activity 5.7116E-3 12 3 1 6292
    ligase activity, forming carbon-carbon bonds 7.6087E-3 12 4 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle