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Catalysis of the reaction: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: leucine-tRNA ligase activity
Acc: GO:0004823
Aspect: Molecular Function
Desc: Catalysis of the reaction: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).
Synonyms:
  • leucyl-transfer ribonucleic acid synthetase activity
  • leucyl-tRNA synthetase activity
  • leucine-tRNA synthetase activity
  • leucyl-transfer ribonucleate synthetase activity
  • leucine translase activity
  • L-leucine:tRNALeu ligase (AMP-forming)
  • leucyl-transfer RNA synthetase activity
Proteins in PDR annotated with:
   This term: 38 [Search]
   Term or descendants: 38 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004823 - leucine-tRNA ligase activity (interactive image map)

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