YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes:	This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Yjl069c. The topolgies of protein complexes in this experiment are unknown.
Complex Size:	26 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
CKA1	protein kinase CK2 complex	G2/M transition of mitotic cell cycle G1/S transition of mitotic cell cycle flocculation via cell wall protein-carbohydrate interaction protein amino acid phosphorylation response to DNA damage stimulus regulation of transcription from RNA polymerase III promoter regulation of transcription from RNA polymerase I promoter cellular ion homeostasis	protein kinase CK2 activity
CKA2	protein kinase CK2 complex	G2/M transition of mitotic cell cycle G1/S transition of mitotic cell cycle flocculation via cell wall protein-carbohydrate interaction protein amino acid phosphorylation response to DNA damage stimulus regulation of transcription from RNA polymerase III promoter regulation of transcription from RNA polymerase I promoter cellular ion homeostasis	protein kinase CK2 activity
CKB1	protein kinase CK2 complex	G2/M transition of mitotic cell cycle G1/S transition of mitotic cell cycle flocculation via cell wall protein-carbohydrate interaction protein amino acid phosphorylation response to DNA damage stimulus regulation of transcription from RNA polymerase III promoter regulation of transcription from RNA polymerase I promoter cellular ion homeostasis	protein kinase CK2 regulator activity
CKB2	protein kinase CK2 complex	G2/M transition of mitotic cell cycle G1/S transition of mitotic cell cycle flocculation via cell wall protein-carbohydrate interaction protein amino acid phosphorylation response to DNA damage stimulus regulation of transcription from RNA polymerase III promoter regulation of transcription from RNA polymerase I promoter cellular ion homeostasis	protein kinase CK2 regulator activity
DIP2	small nucleolar ribonucleoprotein complex	maturation of SSU-rRNA ribosome biogenesis	snoRNA binding
ESL2	nucleus cytoplasm ribosome	biological_process	molecular_function
KRE33	nucleolus	ribosome biogenesis	molecular_function
LCP5	nuclear outer membrane small nuclear ribonucleoprotein complex small nucleolar ribonucleoprotein complex	rRNA modification ribosome biogenesis	RNA binding
NAN1	RENT complex small nucleolar ribonucleoprotein complex	maturation of SSU-rRNA ribosome biogenesis	snoRNA binding
NOP1	nuclear outer membrane nucleolus ribosome small nucleolar ribonucleoprotein complex	rRNA modification RNA methylation maturation of SSU-rRNA ribosome biogenesis ribosomal large subunit assembly snoRNA 3'-end processing	methyltransferase activity
NOP56	box C/D snoRNP complex nucleus nuclear outer membrane nucleolus small nucleolar ribonucleoprotein complex	rRNA modification maturation of SSU-rRNA ribosome biogenesis	molecular_function
PNO1	nucleus nuclear outer membrane nucleolus	protein complex assembly ribosome biogenesis rRNA processing	unfolded protein binding
PRP40	U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding
PTC5	mitochondrion	regulation of catalytic activity	[pyruvate dehydrogenase (lipoamide)] phosphatase activity
PWP2	cytoplasm nuclear outer membrane 90S preribosome small nucleolar ribonucleoprotein complex	maturation of SSU-rRNA cytokinesis ribosome biogenesis	snoRNA binding
RRP5	nuclear outer membrane nucleolus small nucleolar ribonucleoprotein complex	maturation of SSU-rRNA ribosome biogenesis rRNA processing	RNA binding snoRNA binding rRNA primary transcript binding
TFP1	vacuolar proton-transporting V-type ATPase, V1 domain fungal-type vacuole membrane	protein metabolic process vacuolar acidification intron homing	proton-transporting ATPase activity, rotational mechanism endodeoxyribonuclease activity
UTP10	mitochondrion small nucleolar ribonucleoprotein complex	maturation of SSU-rRNA ribosome biogenesis	snoRNA binding
UTP11	small nucleolar ribonucleoprotein complex	maturation of SSU-rRNA ribosome biogenesis	snoRNA binding
UTP13	small nucleolar ribonucleoprotein complex	maturation of SSU-rRNA	snoRNA binding
UTP14	small nucleolar ribonucleoprotein complex	maturation of SSU-rRNA ribosome biogenesis	snoRNA binding
UTP18	nuclear outer membrane nucleolus small nucleolar ribonucleoprotein complex	ribosome biogenesis	molecular_function
UTP21	nucleus nuclear outer membrane nucleolus small nucleolar ribonucleoprotein complex	ribosome biogenesis	snoRNA binding
UTP22	nucleus nuclear outer membrane nucleolus small nucleolar ribonucleoprotein complex	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosome biogenesis rRNA processing	snoRNA binding
UTP30	nucleus nuclear outer membrane nucleolus	ribosome biogenesis	molecular_function
UTP6	small nucleolar ribonucleoprotein complex	maturation of SSU-rRNA ribosome biogenesis	snoRNA binding

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
small nucleolar ribonucleoprotein complex	1.1266E-23	26	72	15	6292
ribonucleoprotein complex	3.9015E-13	26	514	17	6292
nuclear outer membrane	5.9218E-13	26	86	10	6292
nuclear membrane	2.0498E-12	26	97	10	6292
protein kinase CK2 complex	2.2915E-10	26	4	4	6292
macromolecular complex	5.7908E-10	26	1635	22	6292
outer membrane	9.1605E-10	26	178	10	6292
organelle outer membrane	9.1605E-10	26	178	10	6292
nuclear envelope	2.7329E-9	26	199	10	6292
nucleolus	4.8338E-9	26	211	10	6292
nuclear membrane-endoplasmic reticulum network	1.2113E-8	26	232	10	6292
endomembrane system	1.9471E-6	26	398	10	6292
nuclear lumen	6.2983E-6	26	453	10	6292
envelope	1.6599E-5	26	505	10	6292
organelle envelope	1.6599E-5	26	505	10	6292
membrane part	2.8246E-5	26	662	11	6292
organelle membrane	4.2958E-5	26	692	11	6292
nuclear part	1.4944E-4	26	1103	13	6292
organelle lumen	1.6747E-4	26	660	10	6292
intracellular organelle lumen	1.6747E-4	26	660	10	6292
membrane-enclosed lumen	2.7374E-4	26	700	10	6292
non-membrane-bounded organelle	8.2795E-4	26	959	11	6292
intracellular non-membrane-bounded organelle	8.2795E-4	26	959	11	6292
intracellular part	1.8099E-3	26	4938	26	6292
intracellular	2.1987E-3	26	4975	26	6292
membrane	5.288E-3	26	1198	11	6292
box C/D snoRNP complex	8.248E-3	26	2	1	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
maturation of SSU-rRNA	1.2335E-18	26	59	12	6292
rRNA processing	7.9381E-18	26	128	14	6292
ribosome biogenesis	1.4376E-17	26	346	18	6292
rRNA metabolic process	2.1259E-17	26	137	14	6292
ribonucleoprotein complex biogenesis	5.8257E-17	26	374	18	6292
ncRNA processing	1.3072E-14	26	215	14	6292
ncRNA metabolic process	1.5809E-13	26	257	14	6292
RNA processing	1.663E-12	26	380	15	6292
cellular component biogenesis	3.1637E-12	26	694	18	6292
RNA metabolic process	5.2751E-11	26	954	19	6292
regulation of transcription from RNA polymerase I promoter	2.2915E-10	26	4	4	6292
nucleic acid metabolic process	5.453E-9	26	1415	20	6292
regulation of transcription from RNA polymerase III promoter	7.9529E-9	26	7	4	6292
gene expression	1.0142E-8	26	1283	19	6292
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	3.5187E-8	26	1566	20	6292
flocculation via cell wall protein-carbohydrate interaction	4.7318E-8	26	10	4	6292
flocculation	7.4149E-8	26	11	4	6292
cellular nitrogen compound metabolic process	3.2284E-7	26	1770	20	6292
nitrogen compound metabolic process	3.9875E-7	26	1791	20	6292
G2/M transition of mitotic cell cycle	5.0741E-6	26	29	4	6292
transcription from RNA polymerase I promoter	5.8383E-6	26	30	4	6292
transcription from RNA polymerase III promoter	1.5377E-5	26	38	4	6292
cellular macromolecule metabolic process	2.7959E-5	26	2285	20	6292
macromolecule metabolic process	4.4559E-5	26	2349	20	6292
G1/S transition of mitotic cell cycle	4.6387E-5	26	50	4	6292
rRNA modification	4.9065E-5	26	18	3	6292
cellular chemical homeostasis	1.0646E-4	26	119	5	6292
cellular ion homeostasis	1.0646E-4	26	119	5	6292
cellular homeostasis	1.1078E-4	26	120	5	6292
chemical homeostasis	1.2454E-4	26	123	5	6292
ion homeostasis	1.2454E-4	26	123	5	6292
interphase of mitotic cell cycle	6.1168E-4	26	97	4	6292
interphase	6.1168E-4	26	97	4	6292
protein amino acid phosphorylation	7.675E-4	26	103	4	6292
primary metabolic process	1.319E-3	26	2896	20	6292
multi-organism process	2.5915E-3	26	143	4	6292
cellular metabolic process	2.6714E-3	26	3033	20	6292
RNA modification	2.8544E-3	26	70	3	6292
metabolic process	4.8497E-3	26	3157	20	6292
phosphorylation	5.8006E-3	26	179	4	6292
macromolecule modification	6.8206E-3	26	569	7	6292
cellular process	7.3435E-3	26	4426	24	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
snoRNA binding	4.1203E-20	26	31	11	6292
RNA binding	3.8209E-10	26	367	13	6292
nucleic acid binding	5.2524E-7	26	666	13	6292
protein kinase CK2 activity	1.6421E-5	26	2	2	6292
protein kinase CK2 regulator activity	1.6421E-5	26	2	2	6292
obsolete_molecular_function	1.6509E-4	26	69	4	6292
binding	1.7832E-4	26	1294	14	6292
[pyruvate dehydrogenase (lipoamide)] phosphatase activity	4.1322E-3	26	1	1	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis