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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Cdc14. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 17 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ADK1
  • mitochondrial intermembrane space
  • cytoplasm
  • mitochondrion
  • ADP biosynthetic process
  • nucleotide metabolic process
  • adenylate kinase activity
  • ATP3
  • mitochondrial proton-transporting ATP synthase, central stalk
  • mitochondrion
  • ATP synthesis coupled proton transport
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
  • ATP5
  • mitochondrial proton-transporting ATP synthase, stator stalk
  • mitochondrion
  • ATP synthesis coupled proton transport
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
  • ATP7
  • mitochondrial proton-transporting ATP synthase, stator stalk
  • mitochondrion
  • protein complex assembly
  • ATP synthesis coupled proton transport
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
  • CDC14
  • nucleus
  • RENT complex
  • spindle pole body
  • nucleolus
  • regulation of exit from mitosis
  • protein amino acid dephosphorylation
  • phosphoprotein phosphatase activity
  • DPM1
  • mitochondrion
  • nuclear membrane-endoplasmic reticulum network
  • endoplasmic reticulum
  • mitochondrial outer membrane
  • GPI anchor biosynthetic process
  • protein amino acid O-linked glycosylation
  • protein amino acid N-linked glycosylation
  • transferase activity, transferring glycosyl groups
  • dolichyl-phosphate beta-D-mannosyltransferase activity
  • FUR1
  • intracellular
  • pyrimidine salvage
  • uracil phosphoribosyltransferase activity
  • GLC7
  • protein phosphatase type 1 complex
  • mRNA cleavage and polyadenylation specificity factor complex
  • cellular bud neck
  • spindle pole body
  • nuclear outer membrane
  • nucleolus
  • mating projection base
  • mitotic cell cycle spindle assembly checkpoint
  • cell morphogenesis during vegetative growth
  • protein amino acid dephosphorylation
  • chromosome segregation
  • cell budding
  • cellular ion homeostasis
  • meiosis
  • regulation of carbohydrate metabolic process
  • ascospore formation
  • response to heat
  • termination of RNA polymerase II transcription, poly(A)-coupled
  • glycogen metabolic process
  • termination of RNA polymerase II transcription, poly(A)-independent
  • histone dephosphorylation
  • protein serine/threonine phosphatase activity
  • phosphoprotein phosphatase activity
  • RNA binding
  • metal ion binding
  • hydrolase activity
  • HEF3
  • cytosolic ribosome
  • translational elongation
  • ATPase activity
  • translation elongation factor activity
  • HMS1
  • cellular_component
  • pseudohyphal growth
  • transcription factor activity
  • MCR1
  • integral to mitochondrial outer membrane
  • mitochondrial intermembrane space
  • mitochondrion
  • mitochondrial outer membrane
  • response to oxidative stress
  • electron transport
  • ergosterol biosynthetic process
  • cytochrome-b5 reductase activity
  • SNF4
  • nucleus
  • cytoplasm
  • nuclear envelope lumen
  • plasma membrane
  • AMP-activated protein kinase complex
  • peroxisome organization
  • protein amino acid phosphorylation
  • replicative cell aging
  • positive regulation of gluconeogenesis
  • regulation of transcription from RNA polymerase II promoter
  • AMP-activated protein kinase activity
  • protein serine/threonine kinase activator activity
  • SPE3
  • nucleus
  • cytoplasm
  • pantothenate biosynthetic process
  • spermidine biosynthetic process
  • spermidine synthase activity
  • SSZ1
  • cytoplasm
  • regulation of translational fidelity
  • translation
  • unfolded protein binding
  • TPS1
  • cytoplasm
  • alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
  • carbohydrate metabolic process
  • response to drug
  • trehalose biosynthetic process
  • response to stress
  • alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
  • TSA2
  • cytoplasm
  • response to oxidative stress
  • thioredoxin peroxidase activity
  • peroxiredoxin activity
  • VAS1
  • cytoplasm
  • mitochondrion
  • valyl-tRNA aminoacylation
  • valine-tRNA ligase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    mitochondrial proton-transporting ATP synthase complex 1.8158E-5 17 20 3 6292
    proton-transporting ATP synthase complex 1.8158E-5 17 20 3 6292
    proton-transporting ATP synthase, stator stalk 2.0582E-5 17 3 2 6292
    mitochondrial proton-transporting ATP synthase, stator stalk 2.0582E-5 17 3 2 6292
    envelope 2.0682E-5 17 505 8 6292
    organelle envelope 2.0682E-5 17 505 8 6292
    proton-transporting two-sector ATPase complex 1.0167E-4 17 35 3 6292
    mitochondrial envelope 1.1016E-4 17 312 6 6292
    mitochondrial membrane part 1.2197E-4 17 100 4 6292
    organelle envelope lumen 1.5219E-4 17 40 3 6292
    proton-transporting ATP synthase complex, coupling factor F(o) 4.4637E-4 17 12 2 6292
    mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) 4.4637E-4 17 12 2 6292
    mitochondrial membrane 5.2935E-4 17 266 5 6292
    mitochondrial part 1.0808E-3 17 475 6 6292
    proton-transporting two-sector ATPase complex, proton-transporting domain 1.1437E-3 17 19 2 6292
    mitochondrial intermembrane space 4.1015E-3 17 36 2 6292
    cytoplasm 5.6579E-3 17 3552 15 6292
    membrane part 5.9328E-3 17 662 6 6292
    organelle membrane 7.3822E-3 17 692 6 6292
    mitochondrial proton-transporting ATP synthase, central stalk 8.0849E-3 17 3 1 6292
    proton-transporting ATP synthase, central stalk 8.0849E-3 17 3 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    biosynthetic process 1.3994E-6 17 1602 14 6292
    nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process 2.8936E-6 17 90 5 6292
    nucleobase, nucleoside and nucleotide biosynthetic process 2.8936E-6 17 90 5 6292
    purine ribonucleotide biosynthetic process 3.8339E-6 17 42 4 6292
    ribonucleotide biosynthetic process 5.0782E-6 17 45 4 6292
    small molecule metabolic process 5.4719E-6 17 760 10 6292
    purine nucleotide biosynthetic process 7.1736E-6 17 49 4 6292
    small molecule biosynthetic process 8.3565E-6 17 310 7 6292
    purine ribonucleotide metabolic process 9.1205E-6 17 52 4 6292
    ribonucleotide metabolic process 1.1433E-5 17 55 4 6292
    cellular biosynthetic process 1.1466E-5 17 1567 13 6292
    purine nucleotide metabolic process 1.4152E-5 17 58 4 6292
    ATP metabolic process 1.8158E-5 17 20 3 6292
    ATP biosynthetic process 1.8158E-5 17 20 3 6292
    ATP synthesis coupled proton transport 1.8158E-5 17 20 3 6292
    energy coupled proton transport, down electrochemical gradient 1.8158E-5 17 20 3 6292
    phosphorus metabolic process 1.9235E-5 17 229 6 6292
    phosphate metabolic process 1.9235E-5 17 229 6 6292
    purine ribonucleoside triphosphate biosynthetic process 2.4447E-5 17 22 3 6292
    purine nucleoside triphosphate biosynthetic process 2.4447E-5 17 22 3 6292
    cellular nitrogen compound biosynthetic process 2.9603E-5 17 247 6 6292
    nucleotide biosynthetic process 2.9979E-5 17 70 4 6292
    ribonucleoside triphosphate biosynthetic process 3.2024E-5 17 24 3 6292
    hydrogen transport 3.2024E-5 17 24 3 6292
    proton transport 3.2024E-5 17 24 3 6292
    nucleobase, nucleoside and nucleotide metabolic process 4.4062E-5 17 157 5 6292
    purine ribonucleoside triphosphate metabolic process 4.6048E-5 17 27 3 6292
    purine nucleoside triphosphate metabolic process 4.6048E-5 17 27 3 6292
    nucleoside triphosphate biosynthetic process 4.6048E-5 17 27 3 6292
    ribonucleoside triphosphate metabolic process 5.7332E-5 17 29 3 6292
    monovalent inorganic cation transport 7.0292E-5 17 31 3 6292
    ion transmembrane transport 7.7434E-5 17 32 3 6292
    nucleoside triphosphate metabolic process 9.3109E-5 17 34 3 6292
    oxidative phosphorylation 2.315E-4 17 46 3 6292
    nucleotide metabolic process 3.167E-4 17 128 4 6292
    nucleoside phosphate metabolic process 3.167E-4 17 128 4 6292
    primary metabolic process 3.8229E-4 17 2896 15 6292
    heterocycle metabolic process 9.5019E-4 17 171 4 6292
    phosphorylation 1.1275E-3 17 179 4 6292
    metabolic process 1.2152E-3 17 3157 15 6292
    transmembrane transport 1.3172E-3 17 83 3 6292
    generation of precursor metabolites and energy 1.5503E-3 17 195 4 6292
    cation transport 1.9448E-3 17 95 3 6292
    protein amino acid dephosphorylation 2.4923E-3 17 28 2 6292
    translational elongation 2.6727E-3 17 29 2 6292
    ADP biosynthetic process 2.7018E-3 17 1 1 6292
    ADP metabolic process 2.7018E-3 17 1 1 6292
    valyl-tRNA aminoacylation 2.7018E-3 17 1 1 6292
    purine nucleoside diphosphate biosynthetic process 2.7018E-3 17 1 1 6292
    purine nucleoside diphosphate metabolic process 2.7018E-3 17 1 1 6292
    purine ribonucleoside diphosphate metabolic process 2.7018E-3 17 1 1 6292
    ribonucleoside diphosphate metabolic process 2.7018E-3 17 1 1 6292
    ribonucleoside diphosphate biosynthetic process 2.7018E-3 17 1 1 6292
    purine ribonucleoside diphosphate biosynthetic process 2.7018E-3 17 1 1 6292
    ion transport 3.7844E-3 17 120 3 6292
    regulation of carbohydrate metabolic process 4.1015E-3 17 36 2 6292
    cellular metabolic process 4.1361E-3 17 3033 14 6292
    cellular carbohydrate metabolic process 4.5514E-3 17 262 4 6292
    dephosphorylation 5.0459E-3 17 40 2 6292
    spermidine metabolic process 5.3968E-3 17 2 1 6292
    histone dephosphorylation 5.3968E-3 17 2 1 6292
    nucleoside diphosphate biosynthetic process 5.3968E-3 17 2 1 6292
    spermidine biosynthetic process 5.3968E-3 17 2 1 6292
    carbohydrate metabolic process 5.8421E-3 17 281 4 6292
    nucleoside diphosphate metabolic process 8.0849E-3 17 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    hydrogen ion transporting ATP synthase activity, rotational mechanism 7.3081E-6 17 15 3 6292
    hydrogen ion transmembrane transporter activity 3.7325E-4 17 54 3 6292
    monovalent inorganic cation transmembrane transporter activity 4.8512E-4 17 59 3 6292
    inorganic cation transmembrane transporter activity 2.3182E-3 17 101 3 6292
    catalytic activity 2.3594E-3 17 2150 12 6292
    transferase activity, transferring glycosyl groups 2.5204E-3 17 104 3 6292
    dolichyl-phosphate beta-D-mannosyltransferase activity 2.7018E-3 17 1 1 6292
    valine-tRNA ligase activity 2.7018E-3 17 1 1 6292
    spermidine synthase activity 2.7018E-3 17 1 1 6292
    cation transmembrane transporter activity 3.6088E-3 17 118 3 6292
    protein serine/threonine kinase activator activity 5.3968E-3 17 2 1 6292
    uracil phosphoribosyltransferase activity 5.3968E-3 17 2 1 6292
    phosphoprotein phosphatase activity 5.8138E-3 17 43 2 6292
    ion transmembrane transporter activity 6.555E-3 17 146 3 6292
    alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity 8.0849E-3 17 3 1 6292
    cytochrome-b5 reductase activity 8.0849E-3 17 3 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle