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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Yck1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 22 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BCY1
  • nucleus
  • cytoplasm
  • response to heat
  • signal transduction
  • pseudohyphal growth
  • response to stress
  • cAMP-dependent protein kinase inhibitor activity
  • CAR2
  • nucleus
  • cytoplasm
  • arginine catabolic process
  • ornithine-oxo-acid transaminase activity
  • CYS4
  • cytoplasm
  • mitochondrion
  • response to drug
  • cysteine biosynthetic process
  • cystathionine beta-synthase activity
  • GND1
  • cytoplasm
  • mitochondrion
  • response to oxidative stress
  • pentose-phosphate shunt, oxidative branch
  • phosphogluconate dehydrogenase (decarboxylating) activity
  • GTO1
  • peroxisome
  • glutathione metabolic process
  • glutathione transferase activity
  • LAA1
  • AP-1 adaptor complex
  • ribosome
  • clathrin-coated vesicle
  • protein localization
  • retrograde transport, endosome to Golgi
  • molecular_function
  • LYS1
  • cytoplasm
  • lysine biosynthetic process via aminoadipic acid
  • saccharopine dehydrogenase (NAD+, L-lysine-forming) activity
  • SAH1
  • cytoplasm
  • methionine metabolic process
  • selenocysteine metabolic process
  • adenosylhomocysteinase activity
  • SNO2
  • cellular_component
  • pyridoxine metabolic process
  • thiamin biosynthetic process
  • molecular_function
  • SSN8
  • transcription factor complex
  • negative regulation of transcription from RNA polymerase II promoter
  • telomere maintenance
  • meiosis
  • cyclin-dependent protein kinase regulator activity
  • general RNA polymerase II transcription factor activity
  • THI22
  • cellular_component
  • thiamin biosynthetic process
  • phosphomethylpyrimidine kinase activity
  • THO2
  • nucleus
  • THO complex
  • mRNA export from nucleus
  • DNA recombination
  • RNA elongation from RNA polymerase II promoter
  • nucleic acid binding
  • DNA binding
  • TIF1, TIF2
  • plasma membrane enriched fraction
  • eukaryotic translation initiation factor 4F complex
  • cytoplasm
  • ribosome
  • regulation of translation
  • translational initiation
  • regulation of translational initiation
  • translation
  • nucleotide binding
  • nucleic acid binding
  • translation initiation factor activity
  • ATP binding
  • RNA binding
  • ATP-dependent helicase activity
  • helicase activity
  • ATP-dependent RNA helicase activity
  • hydrolase activity
  • TPK2
  • cytoplasm
  • cAMP-dependent protein kinase complex
  • pseudohyphal growth
  • Ras protein signal transduction
  • protein amino acid phosphorylation
  • cAMP-dependent protein kinase activity
  • protein serine/threonine kinase activity
  • TPK3
  • cytoplasm
  • cAMP-dependent protein kinase complex
  • positive regulation of apoptosis
  • pseudohyphal growth
  • protein amino acid phosphorylation
  • cAMP-dependent protein kinase activity
  • protein serine/threonine kinase activity
  • VPS21
  • mitochondrion
  • late endosome
  • mitochondrial outer membrane
  • endocytosis
  • protein targeting to vacuole
  • GTPase activity
  • YBR028C
  • cytoplasm
  • biological_process
  • protein kinase activity
  • YCK1
  • mitochondrion
  • endoplasmic reticulum
  • plasma membrane
  • response to glucose stimulus
  • cell morphogenesis
  • cytokinesis
  • protein amino acid phosphorylation
  • endocytosis
  • casein kinase I activity
  • YCK2
  • cellular bud neck
  • mating projection
  • plasma membrane
  • response to glucose stimulus
  • cell morphogenesis
  • cytokinesis
  • protein amino acid phosphorylation
  • endocytosis
  • casein kinase I activity
  • YCK3
  • nucleus
  • fungal-type vacuole membrane
  • plasma membrane
  • protein amino acid phosphorylation
  • casein kinase I activity
  • YGR111W
  • nucleus
  • cytoplasm
  • regulation of cell size
  • molecular_function
  • YPT53
  • late endosome
  • endocytosis
  • protein targeting to vacuole
  • GTPase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cAMP-dependent protein kinase complex 3.4941E-5 22 3 2 6292
    late endosome 2.5843E-3 22 22 2 6292
    plasma membrane enriched fraction 3.4965E-3 22 1 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    sulfur metabolic process 1.1638E-5 22 90 5 6292
    protein amino acid phosphorylation 2.2507E-5 22 103 5 6292
    response to monosaccharide stimulus 1.1598E-4 22 5 2 6292
    response to glucose stimulus 1.1598E-4 22 5 2 6292
    response to hexose stimulus 1.1598E-4 22 5 2 6292
    response to carbohydrate stimulus 1.736E-4 22 6 2 6292
    endocytosis 2.1559E-4 22 88 4 6292
    membrane invagination 2.7808E-4 22 94 4 6292
    phosphorylation 3.1302E-4 22 179 5 6292
    sulfur compound biosynthetic process 4.1829E-4 22 43 3 6292
    regulation of cell size 5.2518E-4 22 111 4 6292
    regulation of cellular component size 5.8112E-4 22 114 4 6292
    regulation of anatomical structure size 5.8112E-4 22 114 4 6292
    phosphorus metabolic process 9.6875E-4 22 229 5 6292
    phosphate metabolic process 9.6875E-4 22 229 5 6292
    cellular amino acid and derivative metabolic process 1.2655E-3 22 243 5 6292
    pseudohyphal growth 1.6051E-3 22 68 3 6292
    thiamin biosynthetic process 1.9252E-3 22 19 2 6292
    thiamin and derivative biosynthetic process 2.1346E-3 22 20 2 6292
    thiamin metabolic process 2.1346E-3 22 20 2 6292
    thiamin and derivative metabolic process 2.5843E-3 22 22 2 6292
    cell growth 2.8445E-3 22 83 3 6292
    small molecule metabolic process 2.9513E-3 22 760 8 6292
    selenocysteine metabolic process 3.4965E-3 22 1 1 6292
    selenium metabolic process 3.4965E-3 22 1 1 6292
    filamentous growth of a population of unicellular organisms 3.5799E-3 22 90 3 6292
    growth of unicellular organism as a thread of attached cells 3.5799E-3 22 90 3 6292
    serine family amino acid metabolic process 3.8855E-3 22 27 2 6292
    cellular membrane organization 4.458E-3 22 198 4 6292
    membrane organization 4.458E-3 22 198 4 6292
    cellular amino acid metabolic process 4.5389E-3 22 199 4 6292
    vesicle-mediated transport 5.4948E-3 22 340 5 6292
    filamentous growth 5.6698E-3 22 106 3 6292
    sulfur amino acid metabolic process 6.1189E-3 22 34 2 6292
    cellular amine metabolic process 6.6879E-3 22 222 4 6292
    post-translational protein modification 6.7529E-3 22 357 5 6292
    cysteine biosynthetic process 6.9813E-3 22 2 1 6292
    arginine catabolic process 6.9813E-3 22 2 1 6292
    aromatic compound biosynthetic process 8.4005E-3 22 40 2 6292
    amine metabolic process 9.1683E-3 22 243 4 6292
    cellular nitrogen compound biosynthetic process 9.7011E-3 22 247 4 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    casein kinase I activity 1.4811E-7 22 4 3 6292
    cyclic nucleotide-dependent protein kinase activity 3.4941E-5 22 3 2 6292
    cAMP-dependent protein kinase activity 3.4941E-5 22 3 2 6292
    obsolete_molecular_function 1.6743E-3 22 69 3 6292
    trialkylsulfonium hydrolase activity 3.4965E-3 22 1 1 6292
    cAMP-dependent protein kinase inhibitor activity 3.4965E-3 22 1 1 6292
    ornithine-oxo-acid transaminase activity 3.4965E-3 22 1 1 6292
    cystathionine beta-synthase activity 3.4965E-3 22 1 1 6292
    saccharopine dehydrogenase (NAD+, L-lysine-forming) activity 3.4965E-3 22 1 1 6292
    adenosylhomocysteinase activity 3.4965E-3 22 1 1 6292
    kinase activity 6.6879E-3 22 222 4 6292
    phosphogluconate dehydrogenase (decarboxylating) activity 6.9813E-3 22 2 1 6292
    saccharopine dehydrogenase activity 6.9813E-3 22 2 1 6292

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