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Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor. Catalysis of the reaction: N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: saccharopine dehydrogenase (NAD+, L-lysine-forming) activity
Acc: GO:0004754
Aspect: Molecular Function
Desc: Catalysis of the reaction: N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+.
Synonyms:
  • N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)
  • 6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)
  • dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming)
  • N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming)
  • epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming)
Proteins in PDR annotated with:
   This term: 9 [Search]
   Term or descendants: 9 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004754 - saccharopine dehydrogenase (NAD+, L-lysine-forming) activity (interactive image map)
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