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A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses. The lipid bilayer surrounding a clathrin-coated vesicle. A clathrin sculpted lipid bilayer membrane-enclosed vesicle after clathrin release. A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins. A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. A membrane-bounded vesicle found in the cytoplasm of the cell. A vesicle that mediates transport between the trans-Golgi network and other parts of the cell. A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and is secreted these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: clathrin-coated vesicle
Acc: GO:0030136
Aspect: Cellular Component
Desc: A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.
Proteins in PDR annotated with:
   This term: 65 [Search]
   Term or descendants: 565 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0030136 - clathrin-coated vesicle (interactive image map)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle