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View Protein Complex Details

Complex Overview

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
APM1
  • AP-1 adaptor complex
  • vesicle-mediated transport
  • Golgi to vacuole transport
  • clathrin binding
  • CYM1
  • mitochondrial intermembrane space
  • mitochondrion
  • proteolysis
  • metalloendopeptidase activity
  • DOA4
  • membrane fraction
  • endosome
  • mitochondrion
  • proteasome complex
  • protein deubiquitination
  • telomere maintenance
  • regulation of DNA replication
  • endocytosis
  • ubiquitin-dependent protein catabolic process
  • ubiquitin-specific protease activity
  • endopeptidase activity
  • ubiquitin thiolesterase activity
  • hydrolase activity
  • DUR1,2
  • cytoplasm
  • urea metabolic process
  • allantoin catabolic process
  • allophanate hydrolase activity
  • urea carboxylase activity
  • HSP42
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • response to stress
  • unfolded protein binding
  • LAT1
  • mitochondrial pyruvate dehydrogenase complex
  • mitochondrion
  • pyruvate metabolic process
  • dihydrolipoyllysine-residue acetyltransferase activity
  • LPD1
  • mitochondrial pyruvate dehydrogenase complex
  • mitochondrial oxoglutarate dehydrogenase complex
  • mitochondrion
  • glycine cleavage complex
  • mitochondrial nucleoid
  • acetyl-CoA biosynthetic process from pyruvate
  • leucine catabolic process
  • valine catabolic process
  • L-serine biosynthetic process
  • isoleucine catabolic process
  • glycine catabolic process
  • oxoglutarate dehydrogenase (succinyl-transferring) activity
  • pyruvate dehydrogenase (acetyl-transferring) activity
  • glycine dehydrogenase (decarboxylating) activity
  • dihydrolipoyl dehydrogenase activity
  • PDA1
  • mitochondrial pyruvate dehydrogenase complex
  • mitochondrion
  • mitochondrial nucleoid
  • pyruvate metabolic process
  • pyruvate dehydrogenase (acetyl-transferring) activity
  • PDB1
  • mitochondrial pyruvate dehydrogenase complex
  • mitochondrion
  • mitochondrial nucleoid
  • pyruvate metabolic process
  • pyruvate dehydrogenase (acetyl-transferring) activity
  • PDX1
  • mitochondrial pyruvate dehydrogenase complex
  • mitochondrion
  • acetyl-CoA biosynthetic process from pyruvate
  • protein binding
  • PRP46
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • RPN11
  • nucleus
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • TCM62
  • mitochondrion
  • mitochondrial inner membrane
  • protein complex assembly
  • unfolded protein binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    pyruvate dehydrogenase complex 9.4015E-14 13 6 5 6292
    mitochondrial pyruvate dehydrogenase complex 9.4015E-14 13 6 5 6292
    mitochondrial part 1.5378E-5 13 475 7 6292
    mitochondrial matrix 1.7358E-5 13 176 5 6292
    mitochondrial lumen 1.7358E-5 13 176 5 6292
    nucleoid 1.7434E-5 13 26 3 6292
    mitochondrial nucleoid 1.7434E-5 13 26 3 6292
    protein complex 7.088E-5 13 1137 9 6292
    macromolecular complex 1.7639E-4 13 1635 10 6292
    mitochondrion 5.5975E-4 13 1125 8 6292
    membrane-enclosed lumen 1.5991E-3 13 700 6 6292
    proteasome complex 4.2134E-3 13 48 2 6292
    mitochondrial oxoglutarate dehydrogenase complex 6.1865E-3 13 3 1 6292
    oxoglutarate dehydrogenase complex 6.1865E-3 13 3 1 6292
    cytoplasmic part 6.8899E-3 13 2482 10 6292
    organelle lumen 7.8525E-3 13 660 5 6292
    intracellular organelle lumen 7.8525E-3 13 660 5 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    pyruvate metabolic process 1.6343E-8 13 44 5 6292
    acetyl-CoA biosynthetic process from pyruvate 3.9411E-6 13 2 2 6292
    monocarboxylic acid metabolic process 4.5627E-6 13 134 5 6292
    acetyl-CoA biosynthetic process 2.3591E-5 13 4 2 6292
    carboxylic acid metabolic process 3.6448E-4 13 333 5 6292
    organic acid metabolic process 3.6448E-4 13 333 5 6292
    oxoacid metabolic process 3.6448E-4 13 333 5 6292
    cellular ketone metabolic process 4.3563E-4 13 346 5 6292
    acetyl-CoA metabolic process 7.3325E-4 13 20 2 6292
    urea metabolic process 2.0661E-3 13 1 1 6292
    valine catabolic process 2.0661E-3 13 1 1 6292
    valine metabolic process 2.0661E-3 13 1 1 6292
    isoleucine catabolic process 2.0661E-3 13 1 1 6292
    small molecule metabolic process 2.4645E-3 13 760 6 6292
    L-serine metabolic process 4.1283E-3 13 2 1 6292
    L-serine biosynthetic process 4.1283E-3 13 2 1 6292
    leucine catabolic process 4.1283E-3 13 2 1 6292
    coenzyme biosynthetic process 5.5019E-3 13 55 2 6292
    proteolysis 6.0179E-3 13 188 3 6292
    isoleucine metabolic process 6.1865E-3 13 3 1 6292
    branched chain family amino acid catabolic process 8.2408E-3 13 4 1 6292
    cellular catabolic process 8.2693E-3 13 415 4 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    pyruvate dehydrogenase (acetyl-transferring) activity 2.7536E-8 13 4 3 6292
    pyruvate dehydrogenase activity 2.7536E-8 13 4 3 6292
    oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor 6.8758E-8 13 5 3 6292
    oxidoreductase activity, acting on the aldehyde or oxo group of donors 1.5441E-5 13 25 3 6292
    endopeptidase activity 1.6085E-4 13 54 3 6292
    peptidase activity, acting on L-amino acid peptides 8.546E-4 13 95 3 6292
    dihydrolipoyllysine-residue acetyltransferase activity 2.0661E-3 13 1 1 6292
    dihydrolipoyl dehydrogenase activity 2.0661E-3 13 1 1 6292
    allophanate hydrolase activity 2.0661E-3 13 1 1 6292
    dihydrolipoamide S-acyltransferase activity 2.0661E-3 13 1 1 6292
    urea carboxylase activity 2.0661E-3 13 1 1 6292
    ubiquitin thiolesterase activity 4.1283E-3 13 2 1 6292
    S-acetyltransferase activity 4.1283E-3 13 2 1 6292
    oxoglutarate dehydrogenase (succinyl-transferring) activity 4.1283E-3 13 2 1 6292
    peptidase activity 6.3817E-3 13 192 3 6292
    unfolded protein binding 6.7329E-3 13 61 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle